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Chemical Compound Review

Salmosan     4-chloro-9- (dimethoxyphosphorylsulfanylme t...

Synonyms: Azamethphos, Azametiphos, Azamethiphos, Snip, Azamethiophos, ...
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Disease relevance of AI3-29129


High impact information on AI3-29129


Chemical compound and disease context of AI3-29129


Biological context of AI3-29129

  • Inhibition of cholinesterase activity by azamethiphos in gill 'microsomal' fraction gave an IC50 of approximately 100 microM and showed both time and concentration dependence [7].

Associations of AI3-29129 with other chemical compounds


Gene context of AI3-29129

  • Pretreatment of the flies with PB, DEF, or PB+DEF before topical application of azamethiphos resulted in a significant decrease in LD50s in all the strains [1].
  • In a feeding bioassay, spinosad LC50 at 72 h was 0.51 microg of spinosad per gram of sugar, making it 6.3- and 3.5-fold more toxic to house flies compared with azamethiphos and methomyl, respectively [9].
  • A cluster, i.e. a phenotype, with high total AChE activity and high sensitivity to azamethiphos and less sensitivity to inhibition by methomyl and omethoate was shown to be linked to methomyl resistance [6].

Analytical, diagnostic and therapeutic context of AI3-29129


  1. Effect of synergists on the oral and topical toxicity of azamethiphos to organophosphate-resistant houseflies (Diptera: Muscidae). Saito, K., Motoyama, N., Dauterman, W.C. J. Econ. Entomol. (1992) [Pubmed]
  2. First use in North America of azamethiphos to treat Atlantic salmon for sea lice infestation: procedures and efficacy. O'Halloran, J., Hogans, W.E. Can. Vet. J. (1996) [Pubmed]
  3. Genotoxicity testing of some organophosphate insecticides in the Drosophila wing spot test. Cakir, S., Sarikaya, R. Food Chem. Toxicol. (2005) [Pubmed]
  4. Seasonal lethality of the organophosphate pesticide, azamethiphos to female American lobster (Homarus americanus). Burridge, L.E., Haya, K., Waddy, S.L. Ecotoxicol. Environ. Saf. (2005) [Pubmed]
  5. Serum esterase inhibition in birds: a nondestructive biomarker to assess organophosphorus and carbamate contamination. Fossi, M.C., Leonzio, C., Massi, A., Lari, L., Casini, S. Arch. Environ. Contam. Toxicol. (1992) [Pubmed]
  6. Variation of Musca domestica L. acetylcholinesterase in Danish housefly populations. Kristensen, M., Huang, J., Qiao, C.L., Jespersen, J.B. Pest Manag. Sci. (2006) [Pubmed]
  7. Characterisation of choline esterases and their tissue and subcellular distribution in mussel (Mytilus edulis). Brown, M., Davies, I.M., Moffat, C.F., Redshaw, J., Craft, J.A. Mar. Environ. Res. (2004) [Pubmed]
  8. The status and development of insecticide resistance in Danish populations of the housefly Musca domestica L. Kristensen, M., Spencer, A.G., Jespersen, J.B. Pest Manag. Sci. (2001) [Pubmed]
  9. Susceptibility of spinosad in Musca domestica (Diptera: Muscidae) field populations. Kristensen, M., Jespersen, J.B. J. Econ. Entomol. (2004) [Pubmed]
  10. Determination of residues of azamethiphos in salmon tissue by liquid chromatography with fluorescence detection. Pfenning, A.P., Roybal, J.E., Turnipseed, S.B., Gonzales, S.A., Hurlbut, J.A. Journal of AOAC International. (1999) [Pubmed]
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