Disease relevance of methomyl

• After addition of BmT-toxin or methomyl, inhibition of whole cell respiration and swelling of spheroplasts were observed in Escherichia coli cultures producing the novel mitochondrial protein; these effects are similar to those observed with isolated cms-T mitochondria [1].
• The oral toxic dose causing illness in 50% of those exposed to methomyl was estimated to be 0.15 mg/kg of body weight (estimated range, 0.09-0.31 mg/kg of body weight) [2].
• Our data indicate that URF13 has two independent mechanisms for toxicity, one that is mediated by T toxin and methomyl and one that is independent of these toxins [3].
• The URF13 protein, which is encoded by the maize mitochondrial T-urf13 gene, is thought to be responsible for pathotoxin and methomyl sensitivity and male sterility [4].
• The mutagenic activity of five methyl carbamate insecticides-carbaryl, baygon, BUX-Ten, landrin and methomyl-and their nitroso derivatives were investigated using histidine auxotrophs-his TA98, his TA100, his TA1535, his TA1537 and his TA1538--of Salmonella typhimurium LT2 derived by Ames [5].

Psychiatry related information on methomyl

• (iii) For substances with reaction times close to the duration of the dry period, the behavior is driven by the length of the time interval between two rain events, as for example, for methomyl [6].

High impact information on methomyl

• Mitochondria isolated from cms-T maize are specifically sensitive to a toxin (BmT-toxin) produced by the fungal pathogen Bipolaris maydis, race T, and the carbamate insecticide methomyl [1].
• Competition and displacement studies in E. coli demonstrate that toxin binding is reversible and that the toxins and methomyl compete for the same, or for overlapping, binding sites [7].
• Adding methomyl to isolated mitochondria stimulated NADH-linked respiration and uncoupled oxidative phosphorylation, indicating that URF13 was imported into the mitochondria, and conferred toxin sensitivity [4].
• DCCD treatment of K37I-URF13-expressing cells did not protect the cells from permeability caused by T-toxin or methomyl [8].
• Adding T toxin or methomyl to Sf9 cells producing URF13 causes permeabilization of plasma membranes [3].

Chemical compound and disease context of methomyl

• Cross-linking of URF13 oligomers with N,N'-dicyclohexylcarbodiimide (DCCD) protects Escherichia coli cells expressing URF13 and cms-T mitochondria from the permeability caused by T-toxin or methomyl [8].
• The genetic toxicity of methyl methanethiosulfonate (MMT), a hydrolytic derivative of the insecticide methomyl, or lannate (Du Pont), was studied in Salmonella typhimurium, Saccharomyces cerevisiae and Nicotiana tabacum [9].
• Carbamate poisonings (4 men, 2 women, aged 32-60 years) were caused by methomyl (initial blood levels 1.6-57 mg/l) and resulted in death [10].
• INTRODUCTION: Acute pancreatitis subsequent to methomyl (Lannate) had not been reported until 2005, when Markides published the first case [11].
• Acute pancreatitis subsequent to voluntary methomyl and dichlorvos intoxication [11].

Biological context of methomyl

• The carbamate insecticide, methomyl, and the methomyl-containing technical formulation, "Lannate 25", were tested for the induction of DNA damage in vivo [12].
• Furthermore, the results suggest that the HmT toxin and methomyl response is related to the plasmid copy number per cell and that the deleterious effect induced by HmT toxin is stronger than that of methomyl [13].
• Finally, it was shown that, as in T cytoplasm maize mitochondria, HmT toxin and methomyl dissipate the membrane potential of yeast mitochondria that carry the foreign protein [13].
• During twenty applications with a spray pistol of methomyl to chrysanthemums, inhalation exposure as well as potential and actual dermal exposure were monitored using the 'whole-body'-method [14].
• Crystal and molecular structure of carbamate insecticides. 3. Methomyl [15].

Anatomical context of methomyl

• URF13 is a membrane protein unique to mitochondria from maize having the Texas male-sterile cytoplasm (cms-T), which is capable of permeabilizing biological membranes in the presence of a family of pathotoxins (T-toxins) produced by certain fungi or the insecticide methomyl [16].
• Substantial amounts of methomyl (2260-2680 ng/ml) were detected in cerebrospinal fluid and vitreous humor [17].

Associations of methomyl with other chemical compounds

• The poisoning agents in all cases were positively identified as methomyl or aldicarb by gas chromatography-mass spectrometry [18].
• Moreover, a different ratio of CREST-positive/CREST-negative micronuclei was observed with the two products, pure methomyl being relatively more active than Lannate 25 in the induction of CREST-positive micronuclei [19].
• When malate is the substrate oxidized by isolated mitochondria, interaction between the targeted protein and methomyl results in significant inhibition of oxygen uptake [13].
• Determination of residues of methomyl and oxamyl and their oximes in crops by gas-liquid chromatography of oxime trimethylsilyl ethers [20].
• Dual counter-current chromatography (dual CCC) has been successfully applied to rapid sample preparation for the simultaneous determination of residual carbaryl, fenobucarb and methomyl in vegetable oil and citrus fruit [21].

Gene context of methomyl

• The group having the greatest reduction in AChE, the methomyl group, showed less evidence for habituation in an open-field test [22].
• The pesticides assessed are acephate, alachlor, amitrole, azinphos-methyl, benomyl, biphenthrin, bromophos, chlordane, chlorthalonil, cyhalothrin, DDT, EPTC, ethion, folpet, fosetyl-al, glyphosate, isofenphos, methomyl, methyl mercury, paraquat, phosphamidon, systhane, terbutyn, tribultyltin oxide, and vinclozin [23].
• Role of selenium on antioxidant capacity in methomyl-treated mice [24].
• From the above-mentioned findings, it has been concluded that chronic exposure to methomyl insecticide has deleterious effects on rat testes [25].
• Effects of field application of the anti-cholinesterase insecticide methomyl on brain acetylcholinesterase activities in wild Mus musculus [26].

Analytical, diagnostic and therapeutic context of methomyl

• In addition, URF13 is toxic to insect cells grown in culture without T toxins or methomyl; even a T-toxin-insensitive mutant form of URF13 is lethal to cell cultures [3].
• The ability of the carboxylate-specific reagent, N,N'-dicyclohexycarbodiimide, to cross-link URF13 was used in conjunction with site-directed mutagenesis to establish that the URF13 tetramer has a central core consisting of a four-alpha-helical bundle which undergoes a conformational change after interaction with T-toxin or methomyl [27].
• Shift in FTIR spectrum patterns in methomyl-exposed rat spleen cells [28].
• Eleven patients who suffered methomyl poisoning were admitted to the intensive care unit [29].
• The distribution of methomyl in different organs of mice was detected by HPLC [24].

References