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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

PALMOXIRATE     2-tetradecyloxirane-2- carboxylic acid

Synonyms: CHEMBL12394, McN-3802, AG-J-89482, CHEBI:110467, AC1Q5TBZ, ...
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Disease relevance of McN 3802

  • To test whether induction of additional myocyte hypertrophy might prevent pathological LV remodeling after large MI, we administered 2-tetradecylglycidic acid (TDGA) 20 mg/kg/day to sham-operated (n = 12) and MI (n = 10) rats for 10 days, beginning the third day after infarction [1].

High impact information on McN 3802


Biological context of McN 3802


Anatomical context of McN 3802


Associations of McN 3802 with other chemical compounds


Gene context of McN 3802

  • To accomplish this objective, fed or overnight fasted rats were treated with 2-tetradecylglycidic acid (TDGA), a specific, irreversible CPT1 inhibitor, and acute changes in rat epididymal leptin expression and serum leptin content were measured using Northern, RT-PCR, and radioimmunoassay analyses [13].
  • Inhibition of the mitochondrial uptake of long-chain fatty acids was achieved by treating rats with 2-tetradecylglycidic acid (TDGA), a potent inhibitor of the overt form of carnitine palmitoyltransferase (CPT-I) [8].


  1. Induction of myocardial hypertrophy after coronary ligation in rats decreases ventricular dilatation and improves systolic function. Litwin, S.E., Raya, T.E., Anderson, P.G., Litwin, C.M., Bressler, R., Goldman, S. Circulation (1991) [Pubmed]
  2. Effects of inhibition of fatty acid oxidation on myocardial kinetics of 11C-labeled palmitate. Wyns, W., Schwaiger, M., Huang, S.C., Buxton, D.B., Hansen, H., Selin, C., Keen, R., Phelps, M.E., Schelbert, H.R. Circ. Res. (1989) [Pubmed]
  3. Regulation of pathways of extramitochondrial fatty acid oxidation and liver fatty acid-binding protein by long-chain monocarboxylic fatty acids in hepatocytes. Effect of inhibition of carnitine palmitoyltransferase I. Kaikaus, R.M., Sui, Z., Lysenko, N., Wu, N.Y., Ortiz de Montellano, P.R., Ockner, R.K., Bass, N.M. J. Biol. Chem. (1993) [Pubmed]
  4. Role of carnitine and carnitine palmitoyltransferase as integral components of the pathway for membrane phospholipid fatty acid turnover in intact human erythrocytes. Arduini, A., Mancinelli, G., Radatti, G.L., Dottori, S., Molajoni, F., Ramsay, R.R. J. Biol. Chem. (1992) [Pubmed]
  5. Action of the oral hypoglycemic agent 2-tetradecylglycidic acid on hepatic fatty acid oxidation and gluconeogenesis. Tutwiler, G.F., Dellevigne, P. J. Biol. Chem. (1979) [Pubmed]
  6. Prevention of peroxisomal proliferation by carnitine palmitoyltransferase inhibitors in cultured rat hepatocytes and in vivo. Hertz, R., Bar-Tana, J. Biochem. J. (1987) [Pubmed]
  7. Inhibition of hepatic lipogenesis by 2-tetradecylglycidic acid. McCune, S.A., Nomura, T., Harris, R.A. Lipids (1979) [Pubmed]
  8. Effects of 2-tetradecylglycidic acid on rat platelet energy metabolism and aggregation. Ishikura, H., Takeyama, N., Tanaka, T. Biochim. Biophys. Acta (1992) [Pubmed]
  9. Action in vivo and in vitro of 2-tetradecylglycidic acid, 2-tetradecylglycidyl-CoA and 2-tetradecylglycidylcarnitine on hepatic carnitine palmitoyltransferase. Brady, P.S., Brady, L.J. Biochem. J. (1986) [Pubmed]
  10. Effect of the fatty acid oxidation inhibitor 2-tetradecylglycidic acid (TDGA) on glucose and fatty acid oxidation in isolated rat soleus muscle. Tuman, R.W., Joseph, J.M., Brentzel, H.J., Tutwiler, G.F. Int. J. Biochem. (1988) [Pubmed]
  11. Regulation of fatty acid oxidation in isolated hepatocytes and liver mitochondria from newborn rabbits. Herbin, C., Pegorier, J.P., Duee, P.H., Kohl, C., Girard, J. Eur. J. Biochem. (1987) [Pubmed]
  12. Relation of oxidation of long-chain fatty acids to gluconeogenesis in the perfused liver of the guinea pig: effect of 2-tetradecylglycidic acid (McN-3802). Tutwiler, G.F., Brentzel, H.J. Eur. J. Biochem. (1982) [Pubmed]
  13. Activation of leptin expression by an inhibitor of carnitine palmitoyltransferase-1. Wolkowicz, P., Grenett, H., Belousova, M., Urthaler, F. Int. J. Obes. Relat. Metab. Disord. (2004) [Pubmed]
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