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Chemical Compound Review

Levemopamil     (2S)-5-(methyl-phenethyl- amino)-2-phenyl-2...

Synonyms: Levemopamilo, Levemopamilum, SureCN51113, CHEMBL187829, CHEBI:416462, ...
 
 
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Disease relevance of Levemopamil

 

Psychiatry related information on Levemopamil

 

High impact information on Levemopamil

  • Ischemic rats were treated with the N-methyl-D-aspartate receptor antagonist dextromethorphan, 50 mg/kg, with the calcium antagonist levemopamil, 30 mg/kg, with the radical scavenger EPC-K1, 10 mg/kg, or with solvent [3].
  • In a second group of 8 rats with left unilateral ARF the effects of levemopamil (L), a calcium entry blocker with 5-hydroxytryptamine2 (5-HT2) receptor antagonistic properties, were studied [4].
  • Studies in phlebitis. VII: In vitro and in vivo evaluation of pH-solubilized levemopamil [7].
  • The treatment consisted of slow intravenous injections of an aqueous solution of levemopamil given immediately after middle cerebral artery occlusion and again 2 h and 4 h later [8].
  • Body temperature was not affected by levemopamil, suggesting direct cerebroprotection by this drug.(ABSTRACT TRUNCATED AT 250 WORDS)[8]
 

Biological context of Levemopamil

  • Our findings showed that a single administration of levemopamil (10, 15, and 20 mg/kg) significantly and dose-dependently attenuated alcohol intake and increased water intake in P rats [5].
 

Anatomical context of Levemopamil

  • Levemopamil reduces spatial learning deficit following transient occlusion of common carotid arteries in normotensive rats [9].
  • The effect of the calcium channel blocker and 5-HT2 antagonist levemopamil on spatial learning impairment of rats subjected to transient bilateral clamping of carotid arteries (BCCA) was investigated [9].
  • The present study does not provide support for the strategy of combined therapy with dizocilpine (administered before ischemia) and levemopamil (administered before and after ischemia) to protect neurons from injury produced by severe incomplete forebrain ischemia [10].
 

Analytical, diagnostic and therapeutic context of Levemopamil

References

  1. Magnetic resonance imaging study on the effect of levemopamil on the size of intracerebral hemorrhage in rats. Elger, B., Seega, J., Brendel, R. Stroke (1994) [Pubmed]
  2. Effects of levemopamil on neurologic and histologic outcome after cardiac arrest in cats. Fleischer, J.E., Nakakimura, K., Drummond, J.C., Scheller, M.S., Zornow, M.H., Grafe, M.R., Shapiro, H.M. Crit. Care Med. (1992) [Pubmed]
  3. Global ischemic neuronal damage relates to behavioural deficits: a pharmacological approach. Block, F., Schwarz, M. Neuroscience (1998) [Pubmed]
  4. Calcium entry and 5-HT2 receptor blockade in oliguric ischaemic acute renal failure: effects of levemopamil in conscious rats. Kramer, H.J., Rosberg, J., Bäcker, A., Meyer-Lehnert, H. Br. J. Pharmacol. (1996) [Pubmed]
  5. Reduction of spontaneous alcohol drinking and physical withdrawal by levemopamil, a novel Ca2+ channel antagonist, in rats. Rezvani, A.H., Pucilowski, O., Grady, D.R., Janowsky, D., O'Brien, R.A. Pharmacol. Biochem. Behav. (1993) [Pubmed]
  6. Levemopamil injection after cerebral oligemia reduces spatial memory deficits in rats. Heim, C., Sieklucka, M., Sontag, K.H. Pharmacol. Biochem. Behav. (1994) [Pubmed]
  7. Studies in phlebitis. VII: In vitro and in vivo evaluation of pH-solubilized levemopamil. Myrdal, P.B., Simamora, P., Surakitbanharn, Y., Yalkowsky, S.H. Journal of pharmaceutical sciences. (1995) [Pubmed]
  8. Oedema reduction by levemopamil in focal cerebral ischaemia of spontaneously hypertensive rats studied by magnetic resonance imaging. Elger, B., Seega, J., Raschack, M. Eur. J. Pharmacol. (1994) [Pubmed]
  9. Levemopamil reduces spatial learning deficit following transient occlusion of common carotid arteries in normotensive rats. Block, F., Szabo, L., Jaspers, R.M., Heim, C., Sontag, K.H. Acta neurologica Scandinavica. (1993) [Pubmed]
  10. Combined therapy with dizocilpine and levemopamil does not reduce ischemic neuronal injury in rats. Sano, T., Patel, P.M., Drummond, J.C., Cole, D.J. Journal of neurosurgical anesthesiology. (1993) [Pubmed]
  11. Failure of levemopamil to improve histological outcome following temporary occlusion of the middle cerebral artery in cats. Gomi, S., Greenberg, J.H., Croul, S., Reivich, M. J. Neurol. Sci. (1995) [Pubmed]
 
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