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Chemical Compound Review

Oxaine M     magnesium dihydroxide

Synonyms: ACMC-1BQGA, CHEBI:6637, AG-D-62795, AG-L-18566, CHEMBL1200718, ...
 
 
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Disease relevance of Magnesium hydrate

  • When plasma PO4 increased above 2 mmol/l, the dose of Mg(OH)2 was increased to the highest dose not inducing diarrhea, hypermagnesemia (less than 2 mmol/l) or hyperkalemia (less than 6 mmol/l) [1].
  • Concentration of coliphages from drinking water by Mg(OH)2 flocculation [2].
  • The purpose of this study was to develop a stable single-dose vaccine based on recombinant hepatitis B surface antigen (HBsAg) in poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres, in which HBsAg was stabilized by a protein stabilizer (trehalose) and an antacid (Mg(OH)2) [3].
 

High impact information on Magnesium hydrate

  • To obtain a diarrhea control group for transit time and bile acid absorption, normal subjects were studied when they had diarrhea caused by ingestion of Milk of Magnesia (MOM) [4].
  • The production of H2 has been examined in the gamma-ray and 5 MeV He ion radiolysis of CaCl2.2H2O, CaCl2.6H2O, Ca(OH)2, MgCl2.2H2O, MgCl2.6H2O, and Mg(OH)2 [5].
  • Antacid excipients such as Mg(OH)2, which increase both microclimate pH and polymer water uptake, have been shown to prevent acid-induced instability of proteins encapsulated in PLGA [6].
  • The purpose of this study was to delineate the effects of microclimate pH and polymer water content on the stability of encapsulated bovine serum albumin (BSA) by comparing the effects of Mg(OH)2 with those of another excipient, sucrose, which increases polymer water content without significantly affecting acid-base chemistry of the polymer [6].
  • Near infrared spectroscopy (NIR) indicated a dehydrated dihydrate of erythromycin is produced during formulation and gradually binds with Mg(OH)2 [7].
 

Biological context of Magnesium hydrate

  • The neutralization of acidic PLGA microclimate by addition of 3-10% Mg(OH)2 completely inhibited deformylation of VCR during release. but introduced a new degradation product formed under the more alkaline conditions used during the preparation [8].
 

Associations of Magnesium hydrate with other chemical compounds

  • Diffuse reflection infrared Fourier transform (DRIFT) spectra of the hydroxides Mg(OH)2 and Zn(OH)F and the iodate hydrates beta-Ni(IO3)2.4H2O and Ni(IO3)2.2H2O have been recorded at ambient and high temperature [9].
  • After sample fusion with Na2O2 and interference separation with ammonium pyrrolidinedithiocarbamate chelate, REE analytes were coprecipitated with Mg(OH)2 at pH 8.5, and then prepared into a water medium for CE determination [10].
  • With Mg2+ as chloride, titration gives a mixture of Cr(OH)3 and Mg(OH)2, but the metal sulfates give Mg2Cr(OH)6 1/2(SO4) by a two-step process [11].
 

Gene context of Magnesium hydrate

 

Analytical, diagnostic and therapeutic context of Magnesium hydrate

  • To improve the stability of the protein within microspheres and allow the release of biologically active lysozyme, a basic additive ( Mg(OH)2 ) was successfully encapsulated [12].
  • Microspheres were eroded in pH 7.4 buffer at 37 degrees C. The ratio of encapsulated lactone to carboxylate was determined by HPLC as a function of time, initial form of drug encapsulated, fraction of co-encapsulated Mg(OH)2, CPT lipophilicity, and drug loading [13].
  • The microencapsulation of Mg(OH)2 had negative effects on tissue mass and matrix accumulation [14].

References

  1. Prevention of hyperparathyroidism in patients on maintenance dialysis by intravenous 1-alpha-hydroxyvitamin D3 in association with Mg(OH)2 as sole phosphate binder. A randomized comparative study with the association CaCO3 +/- Mg(OH)2. Mornière, P., Maurouard, C., Boudailliez, B., Westeel, P.F., Achard, J.M., Boitte, F., el Esper, N., Compagnon, M., Maurel, G., Bouillon, R. Nephron (1992) [Pubmed]
  2. Concentration of coliphages from drinking water by Mg(OH)2 flocculation. Schulze, E., Lenk, J. Naturwissenschaften (1983) [Pubmed]
  3. Development of a single-dose stabilized poly(D,L-lactic-co-glycolic acid) microspheres-based vaccine against hepatitis B. Jaganathan, K.S., Singh, P., Prabakaran, D., Mishra, V., Vyas, S.P. J. Pharm. Pharmacol. (2004) [Pubmed]
  4. Rapid intestinal transit as a primary cause of severe chronic diarrhea in patients with amyloidosis. Guirl, M.J., Högenauer, C., Santa Ana, C.A., Porter, J.L., Little, K.H., Stone, M.J., Fordtran, J.S. Am. J. Gastroenterol. (2003) [Pubmed]
  5. H2 and Cl2 production in the radiolysis of calcium and magnesium chlorides and hydroxides. LaVerne, J.A., Tandon, L. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2005) [Pubmed]
  6. Comparison of the effects of Mg(OH)2 and sucrose on the stability of bovine serum albumin encapsulated in injectable poly(D,L-lactide-co-glycolide) implants. Kang, J., Schwendeman, S.P. Biomaterials (2002) [Pubmed]
  7. Role of an isomorphic desolvate in dissolution failures of an erythromycin tablet formulation. Bauer, J.F., Dziki, W., Quick, J.E. Journal of pharmaceutical sciences. (1999) [Pubmed]
  8. Stabilization of vinca alkaloids encapsulated in poly(lactide-co-glycolide) microspheres. Marinina, J., Shenderova, A., Mallery, S.R., Schwendeman, S.P. Pharm. Res. (2000) [Pubmed]
  9. Diffuse reflection infrared Fourier transform (DRIFT) spectra and high-temperature DRIFT spectra of beta-Ni(IO3)2.4H2O, Ni(IO3)2.2H2O, Mg(OH)2, and Zn(OH)F: novel embedding materials. Pracht, G., Weckler, B., Lutz, H.D. Applied spectroscopy. (2003) [Pubmed]
  10. Applicability of capillary electrophoresis to the analysis of trace rare earth elements in geological samples. Sun, Y., Sun, M., Zhao, G. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. (2006) [Pubmed]
  11. Layered double hydroxide stability. 2. Formation of Cr(III)-containing layered double hydroxides directly from solution. Boclair, J.W., Braterman, P.S., Jiang, J., Lou, S., Yarberry, F. Chemistry of materials : a publication of the American Chemical Society. (1999) [Pubmed]
  12. A novel in vitro delivery system for assessing the biological integrity of protein upon release from PLGA microspheres. Aubert-Pouëssel, A., Bibby, D.C., Venier-Julienne, M.C., Hindré, F., Benoît, J.P. Pharm. Res. (2002) [Pubmed]
  13. The acidic microclimate in poly(lactide-co-glycolide) microspheres stabilizes camptothecins. Shenderova, A., Burke, T.G., Schwendeman, S.P. Pharm. Res. (1999) [Pubmed]
  14. A novel injectable approach for cartilage formation in vivo using PLG microspheres. Mercier, N.R., Costantino, H.R., Tracy, M.A., Bonassar, L.J. Annals of biomedical engineering. (2004) [Pubmed]
 
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