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Chemical Compound Review

iodate     iodate

Synonyms: Iodate ion, Iodate(1-), IO3-, Iodate anion, AG-E-02504, ...
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Disease relevance of iodate

  • Lavage of a mucinous cystadenoma of the pancreas with povidone iodate [1].
  • Serum thyroid-stimulating autoantibodies (LATS and LATS protector) and thyrotropin (TSH) concentrations were measured in the serum of 30 patients with hyperthyroidism living in Tasmania who developed their disease following correction of iodine deficiency by addition of iodate to the bread [2].
  • Damaging the RPE with sodium iodate caused the resorption time, for blebs made with an ionic solution (Hanks'), to decrease from 2-6 hours to only about 30 minutes [3].
  • To determine the role of retinal pigment epithelium in the induction of S-antigen-induced uveitis by administration of sodium iodate (NaIO3) to selectively damage the retinal pigment epithelium [4].
  • The studies do not meet current standards of toxicity testing, mostly because they lacked toxicokinetic data and did not separate iodate-specific effects from the effects of an overdose of any form of iodine [5].

High impact information on iodate

  • Single-crystal X-ray diffraction experiments reveal that 1 possesses a corrugated layered structure constructed from molybdenum oxide chains that are bridged by iodate anions [6].
  • Phosphate and iodate are both found to bind to the three metal ions in the protein molecule, suggesting that these ions are involved directly in the catalytic process and thereby identifying the active site [7].
  • PURPOSE: To characterize chemoattractants expressed by the retinal pigment epithelium (RPE) after sodium iodate (NaIO3)-induced damage and to investigate whether ocular-committed stem cells preexist in the bone marrow (BM) and migrate in response to the chemoattractive signals expressed by the damaged RPE [8].
  • RPE damage was also induced by sodium iodate injection (40 mg/kg) into wild-type or albino C57Bl/6 mice [9].
  • The applicability of the proposed tITP-CE method could apparently be extended to the determination of other trace seawater anions (e.g., iodate) [10].

Chemical compound and disease context of iodate


Biological context of iodate

  • The kinetics of the radioactive iodine exchange reaction for the preparation of [123I]HIDM is controlled by the pH, the temperature, and the presence of reductant (sodium bisulfite), and oxidant (sodium iodate) [14].
  • By contrast, the oxidants periodate, iodate, and hydrogen peroxide (applied for the same time, but at higher concentrations) merely produced a parallel shift of the h infinity(E) curve to more negative values of membrane potential [15].
  • Effects of intravenous iodoacetate (a glycolysis inhibitor) and iodate (a metabolism inhibitor selective to retinal pigment epithelium) on light-evoked alkalinizations and hypoxia-induced acidifications were studied in the dark-adapted cat retina, in vivo, to learn about pH regulation [16].
  • Iodate (IO3-) inhibited the FSK, ISO, and VO3- activations of AC in ciliary process membranes (IC50, 0.3 mM) [17].
  • The outward active transport and the inward permeability of the blood-retinal barrier were studied in the rabbit eye after i.v. administration of sodium iodate [18].

Anatomical context of iodate


Associations of iodate with other chemical compounds


Gene context of iodate

  • The oxidation of Sb(III) with iodate was measured in 0.5 mol L(-1) NaCl solutions as a function of pH at environmentally significant concentrations of antimony and iodate [29].
  • Combined action of intraaxonal iodate and external sea anemone toxin ATX II on sodium channel inactivation of frog nerve fibres [30].
  • The activation of bovine spleen NMT with thiol reducing compounds, and its inhibition by the oxidizing agent sodium iodate, suggest a role for oxidation/reduction in NMT regulation [31].
  • Monomeric vanadate is a potent competitive inhibitor of phospholipase C from Bacillus cereus, much better than other oxyanions (e.g., phosphate or iodate) [32].

Analytical, diagnostic and therapeutic context of iodate


  1. Lavage of a mucinous cystadenoma of the pancreas with povidone iodate. Gaia, E., Salacone, P., Cataldi, A. Gut (2006) [Pubmed]
  2. Hyperthyroidism in Tasmania following iodide supplementation: measurements of thyroid-stimulating autoantibodies and thyrotropin. Adams, D.D., Kennedy, T.H., Stewart, J.C., Utiger, R.D., Vidor, G.I. J. Clin. Endocrinol. Metab. (1975) [Pubmed]
  3. The resorption of subretinal fluid after diffuse damage to the retinal pigment epithelium. Negi, A., Marmor, M.F. Invest. Ophthalmol. Vis. Sci. (1983) [Pubmed]
  4. Role of retinal pigment epithelium in the development of experimental autoimmune uveitis. Konda, B.R., Pararajasegaram, G., Wu, G.S., Stanforth, D., Rao, N.A. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  5. The toxicology of iodate: a review of the literature. Bürgi, H., Schaffner, T.H., Seiler, J.P. Thyroid (2001) [Pubmed]
  6. Structural modulation of molybdenyl iodate architectures by alkali metal cations in AMoO3(IO3) (A = K, Rb, Cs): a facile route to new polar materials with large SHG responses. Sykora, R.E., Ok, K.M., Halasyamani, P.S., Albrecht-Schmitt, T.E. J. Am. Chem. Soc. (2002) [Pubmed]
  7. Crystal structures of phosphate, iodide and iodate-inhibited phospholipase C from Bacillus cereus and structural investigations of the binding of reaction products and a substrate analogue. Hansen, S., Hansen, L.K., Hough, E. J. Mol. Biol. (1992) [Pubmed]
  8. Retinal pigment epithelium damage enhances expression of chemoattractants and migration of bone marrow-derived stem cells. Li, Y., Reca, R.G., Atmaca-Sonmez, P., Ratajczak, M.Z., Ildstad, S.T., Kaplan, H.J., Enzmann, V. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  9. Bone marrow-derived cells home to and regenerate retinal pigment epithelium after injury. Harris, J.R., Brown, G.A., Jorgensen, M., Kaushal, S., Ellis, E.A., Grant, M.B., Scott, E.W. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  10. Trace ion analysis of seawater by capillary electrophoresis: determination of iodide using transient isotachophoretic preconcentration. Hirokawa, T., Ichihara, T., Ito, K., Timerbaev, A.R. Electrophoresis (2003) [Pubmed]
  11. Fluorometric studies on the blood-retinal barrier in experimental animals. Krupin, T., Waltman, S.R., Szewczyk, P., Koloms, B., Farber, M., Silverstein, B., Becker, B. Arch. Ophthalmol. (1982) [Pubmed]
  12. Comparison of toxicity induced by iodine and iodide in male and female rats. Sherer, T.T., Thrall, K.D., Bull, R.J. Journal of toxicology and environmental health. (1991) [Pubmed]
  13. Can potentials from the visual cortex be elicited electrically despite severe retinal degeneration and a markedly reduced electroretinogram? Humayun, M., Sato, Y., Propst, R., de Juan, E. German journal of ophthalmology. (1995) [Pubmed]
  14. Radioactive iodine exchange reaction of HIPDM: kinetics and mechanism. Lui, B., Chang, J., Sun, J.S., Billings, J., Steves, A., Ackerhalt, R., Molnar, M., Kung, H.F. J. Nucl. Med. (1987) [Pubmed]
  15. Effects of some chemical reagents on sodium current inactivation in myelinated nerve fibers of the frog. Rack, M., Rubly, N., Waschow, C. Biophys. J. (1986) [Pubmed]
  16. Effects of intravenous iodoacetate and iodate on pH outside rod photoreceptors in the cat retina. Yamamoto, F., Honda, Y. Invest. Ophthalmol. Vis. Sci. (1993) [Pubmed]
  17. Interaction of vanadate and iodate oxyanions with adenylyl cyclase of ciliary processes. Mittag, T.W., Guo, W.B., Taniguchi, T. Biochem. Pharmacol. (1993) [Pubmed]
  18. Transport of fluorescein in the rabbit eye after treatment with sodium iodate. Kitano, S., Hori, S., Nagataki, S. Exp. Eye Res. (1988) [Pubmed]
  19. Albumin movement out of the subretinal space after experimental retinal detachment. Takeuchi, A., Kricorian, G., Marmor, M.F. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  20. Analysis of immune deviation elicited by antigens injected into the subretinal space. Wenkel, H., Streilein, J.W. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  21. RPE destruction causes choriocapillary atrophy. Korte, G.E., Reppucci, V., Henkind, P. Invest. Ophthalmol. Vis. Sci. (1984) [Pubmed]
  22. Sucrose permeability of the blood-retinal and blood-brain barriers. Effects of diabetes, hypertonicity, and iodate. Ennis, S.R., Betz, A.L. Invest. Ophthalmol. Vis. Sci. (1986) [Pubmed]
  23. Enhanced induction of RPE lineage markers in pluripotent neural stem cells engrafted into the adult rat subretinal space. Enzmann, V., Howard, R.M., Yamauchi, Y., Whittemore, S.R., Kaplan, H.J. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  24. Differential pulse polarographic analysis of thyroid hormone: determination of iodine, thyroxine, and liothyronine. Holak, W., Shostak, D. Journal of pharmaceutical sciences. (1979) [Pubmed]
  25. Transient breakdown of the retinal pigment epithelium diffusion barrier after sodium iodate: a fluorescein angiographic and morphological study in the rabbit. Ringvold, A., Olsen, E.G., Flage, T. Exp. Eye Res. (1981) [Pubmed]
  26. Murine cytomegalovirus (MCMV) spreads to and replicates in the retina after endotoxin-induced disruption of the blood-retinal barrier of immunosuppressed BALB/c mice. Zhang, M., Xin, H., Atherton, S.S. J. Neurovirol. (2005) [Pubmed]
  27. Intravitreal chemotactic and mitogenic activity. Implication of blood-retinal barrier breakdown. Campochiaro, P.A., Bryan, J.A., Conway, B.P., Jaccoma, E.H. Arch. Ophthalmol. (1986) [Pubmed]
  28. Behaviour of chemically modified sodium channels in frog nerve supports a three-state model of inactivation. Schmidtmayer, J. Pflugers Arch. (1985) [Pubmed]
  29. Sb(III) oxidation by iodate in seawater: a cautionary tale. Quentel, F., Filella, M., Elleouet, C., Madec, C.L. Sci. Total Environ. (2006) [Pubmed]
  30. Combined action of intraaxonal iodate and external sea anemone toxin ATX II on sodium channel inactivation of frog nerve fibres. Schmidtmayer, J., Stoye-Herzog, M., Ulbricht, W. Pflugers Arch. (1983) [Pubmed]
  31. Coenzyme A dependent myristoylation and demyristoylation in the regulation of bovine spleen N-myristoyltransferase. Raju, R.V., Sharma, R.K. Mol. Cell. Biochem. (1996) [Pubmed]
  32. Vanadate is a potent competitive inhibitor of phospholipase C from Bacillus cereus. Tan, C.A., Roberts, M.F. Biochim. Biophys. Acta (1996) [Pubmed]
  33. Choriocapillaris regeneration in the rabbit. Ultrastructure of new endothelial tube formation. Korte, G.E. Invest. Ophthalmol. Vis. Sci. (1989) [Pubmed]
  34. In vivo imaging of breakdown of the inner and outer blood-retinal barriers. Sen, H.A., Berkowitz, B.A., Ando, N., de Juan, E. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  35. Labelling of regenerating retinal pigment epithelium by colloidal iron oxide and ferritin conjugated to wheat germ agglutinin. Korte, G.E. Cell Tissue Res. (1991) [Pubmed]
  36. Alteration of the blood-retinal barrier by sodium iodate: kinetic vitreous fluorophotometry and horseradish peroxidase tracer studies. Anstadt, B., Blair, N.P., Rusin, M., Cunha-Vaz, J.G., Tso, M.O. Exp. Eye Res. (1982) [Pubmed]
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