Disease relevance of Microclimate

• Mild hypothermia (-1 degree C) was induced by controlled circulation of propylene glycol through a 'microclimate' head and vest garment while reductions in oral and limb temperatures were monitored [1].

High impact information on Microclimate

• High mucosal acidity, similar to the pH occurring within the fluid microclimate domain at the mucosal surface of the intestine, markedly enhances the cGMP accumulation responses of T84 human intestinal cells to uroguanylin [2].
• Prediction of Microclimate pH in Poly(lactic-co-glycolic Acid) Films [3].
• When valinomycin or triaminopyrimidine were added to the mucosal solution at high K+ concentrations in the luminal solutions the K+ concentration in the microclimate was raised [4].
• The importance of mucus in maintaining the microclimate was shown by n-acetyl cysteine thinning and prostaglandin E2 thickening the layer [5].
• 5. Glycylglycine and L-carnosine were found to reduce the microclimate pH gradient significantly, while glycine did not [6].

Anatomical context of Microclimate

• The results suggested that OATP-B mediates absorption of anionic compounds and its activity may be optimum at the acidic surface microclimate pH of the small intestine [7].
• 5. The favourable elevation of microclimate pH by STa seemed to be outweighted by the reduced fluid absorption in the ileum [8].
• The influence of buffer pH, glucose and sodium ion concentration on the acid microclimate in rat proximal jejunum in vitro [9].
• The location of CA II in the apical cell region suggests a role for this isoenzyme in regulation of the microclimate close to the epithelial cells [10].

Associations of Microclimate with chemical compounds

• Under control conditions K+ concentrations in the microclimate of the proximal colon were also low (6-9 mmol/l) and rather independent from K+ concentrations in the bulk luminal solution [4].
• An ATPase dependent, radiosensitive acidic microclimate essential for intestinal folate absorption [11].
• 8. The 5-methyltetrahydrofolic acid may be converted to its zwitterion in an acid microclimate at the surface of the intestinal absorbing cell [12].
• It is plausible that generation of the protons, which are secreted into the acid microclimate zone, is closely related to the intracellular metabolization of glucose [13].
• Using these methods, the variation in occupancy and abundance of the clouded apollo butterfly (Parnassius mnemosyne L.) was decomposed into independent and joint effects of larval and adult food resources, microclimate and habitat quantity [14].

Gene context of Microclimate

• The significance of this is discussed in relation to other RA symptoms, meteorologic phenomena, microclimate, and the joint circulatory responses in RA [15].
• It seems likely that the enhanced absorption with STa exposure is related to the effect of STa on the microclimate pH [8].
• The purpose of this study was to delineate the effects of microclimate pH and polymer water content on the stability of encapsulated bovine serum albumin (BSA) by comparing the effects of Mg(OH)2 with those of another excipient, sucrose, which increases polymer water content without significantly affecting acid-base chemistry of the polymer [16].
• Daily changes in microclimate temperature and supercooling point (SCP) of Collembola were measured during summer at Cape Hallett, North Victoria Land, Antarctica [17].
• This study provides the first in vivo evidence that H. pylori can increase the antral juxtamucosal pH and suggests that ammonia production by the organism is capable of altering gastric mucus microclimate to impair the normal negative feedback controlling gastrin release [18].

References