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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Microclimate


High impact information on Microclimate


Anatomical context of Microclimate


Associations of Microclimate with chemical compounds

  • Under control conditions K+ concentrations in the microclimate of the proximal colon were also low (6-9 mmol/l) and rather independent from K+ concentrations in the bulk luminal solution [4].
  • An ATPase dependent, radiosensitive acidic microclimate essential for intestinal folate absorption [11].
  • 8. The 5-methyltetrahydrofolic acid may be converted to its zwitterion in an acid microclimate at the surface of the intestinal absorbing cell [12].
  • It is plausible that generation of the protons, which are secreted into the acid microclimate zone, is closely related to the intracellular metabolization of glucose [13].
  • Using these methods, the variation in occupancy and abundance of the clouded apollo butterfly (Parnassius mnemosyne L.) was decomposed into independent and joint effects of larval and adult food resources, microclimate and habitat quantity [14].

Gene context of Microclimate

  • The significance of this is discussed in relation to other RA symptoms, meteorologic phenomena, microclimate, and the joint circulatory responses in RA [15].
  • It seems likely that the enhanced absorption with STa exposure is related to the effect of STa on the microclimate pH [8].
  • The purpose of this study was to delineate the effects of microclimate pH and polymer water content on the stability of encapsulated bovine serum albumin (BSA) by comparing the effects of Mg(OH)2 with those of another excipient, sucrose, which increases polymer water content without significantly affecting acid-base chemistry of the polymer [16].
  • Daily changes in microclimate temperature and supercooling point (SCP) of Collembola were measured during summer at Cape Hallett, North Victoria Land, Antarctica [17].
  • This study provides the first in vivo evidence that H. pylori can increase the antral juxtamucosal pH and suggests that ammonia production by the organism is capable of altering gastric mucus microclimate to impair the normal negative feedback controlling gastrin release [18].


  1. Effects of induced hypothermia on somatosensory evoked potentials in patients with chronic spinal cord injury. Hayes, K.C., Hsieh, J.T., Potter, P.J., Wolfe, D.L., Delaney, G.A., Blight, A.R. Paraplegia. (1993) [Pubmed]
  2. Regulation of intestinal uroguanylin/guanylin receptor-mediated responses by mucosal acidity. Hamra, F.K., Eber, S.L., Chin, D.T., Currie, M.G., Forte, L.R. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  3. Prediction of Microclimate pH in Poly(lactic-co-glycolic Acid) Films. Ding, A.G., Shenderova, A., Schwendeman, S.P. J. Am. Chem. Soc. (2006) [Pubmed]
  4. Factors affecting the potassium concentration at the mucosal surface of the proximal and the distal colon of guinea pig. Kück-Biere, U., von Engelhardt, W. Gut (1990) [Pubmed]
  5. Mucosal surface pH of the large intestine of the rat and of normal and inflamed large intestine in man. McNeil, N.I., Ling, K.L., Wager, J. Gut (1987) [Pubmed]
  6. Factors affecting the microclimate pH in rat jejunum. Shimada, T. J. Physiol. (Lond.) (1987) [Pubmed]
  7. Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. Kobayashi, D., Nozawa, T., Imai, K., Nezu, J., Tsuji, A., Tamai, I. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  8. The effect of E. coli STa enterotoxin on the absorption of weakly dissociable anti-malarial drugs from rat intestine in vivo. Rawlings, J.M., Lynch, J., Lucas, M.L. Br. J. Pharmacol. (1991) [Pubmed]
  9. The influence of buffer pH, glucose and sodium ion concentration on the acid microclimate in rat proximal jejunum in vitro. Lucas, M.L., Lei, F.H., Blair, J.A. Pflugers Arch. (1980) [Pubmed]
  10. Carbonic anhydrase isoenzymes in the caecum and colon of normal and germ-free rats. Lönnerholm, G., Midtvedt, T., Schenholm, M., Wistrand, P.J. Acta Physiol. Scand. (1988) [Pubmed]
  11. An ATPase dependent, radiosensitive acidic microclimate essential for intestinal folate absorption. Kesavan, V., Noronha, J.M. J. Physiol. (Lond.) (1978) [Pubmed]
  12. Uptake of 5-methyltetrahydrofolic acid by the rat jejunum. Blair, J.A., Matty, A.J., Razzaque, A. J. Physiol. (Lond.) (1975) [Pubmed]
  13. Effect of metabolizable sugars on the mucosal surface pH of rat intestine. Daniel, H., Rehner, G. J. Nutr. (1986) [Pubmed]
  14. New insights into butterfly-environment relationships using partitioning methods. Heikkinen, R.K., Luoto, M., Kuussaari, M., Pöyry, J. Proc. Biol. Sci. (2005) [Pubmed]
  15. Annual fluctuations in rheumatoid arthritis. Latman, N.S. J. Rheumatol. (1981) [Pubmed]
  16. Comparison of the effects of Mg(OH)2 and sucrose on the stability of bovine serum albumin encapsulated in injectable poly(D,L-lactide-co-glycolide) implants. Kang, J., Schwendeman, S.P. Biomaterials (2002) [Pubmed]
  17. Diurnal variation in supercooling points of three species of Collembola from Cape Hallett, Antarctica. Sinclair, B.J., Jaco Klok, C., Scott, M.B., Terblanche, J.S., Chown, S.L. J. Insect Physiol. (2003) [Pubmed]
  18. Helicobacter pylori increases gastric antral juxtamucosal pH. Kelly, S.M., Crampton, J.R., Hunter, J.O. Dig. Dis. Sci. (1993) [Pubmed]
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