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Chemical Compound Review

EDHB     ethyl 3,4-dihydroxybenzoate

Synonyms: PubChem4051, SureCN39791, CHEMBL486216, ACMC-1CJ7A, E24859_ALDRICH, ...
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Disease relevance of NSC86130


High impact information on NSC86130


Chemical compound and disease context of NSC86130

  • Three distinct prolyl 4-hydroxylase inhibitors-l-mimosine (L-Mim), ethyl 3,4-dihydroxybenzoate (3,4-DHB), and 6-chlor-3-hydroxychinolin-2-carbonic acid-N-carboxymethylamid (S956711)-demonstrated similar effects to hypoxia (0.5% O2) by inducing HIFalpha protein in human and rodent cells [5].

Biological context of NSC86130


Anatomical context of NSC86130


Gene context of NSC86130


  1. Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes. Wright, G., Higgin, J.J., Raines, R.T., Steenbergen, C., Murphy, E. J. Biol. Chem. (2003) [Pubmed]
  2. Reduction of collagen production in keloid fibroblast cultures by ethyl-3,4-dihydroxybenzoate. Inhibition of prolyl hydroxylase activity as a mechanism of action. Sasaki, T., Majamaa, K., Uitto, J. J. Biol. Chem. (1987) [Pubmed]
  3. Evidence for a role of collagen synthesis in arterial smooth muscle cell migration. Rocnik, E.F., Chan, B.M., Pickering, J.G. J. Clin. Invest. (1998) [Pubmed]
  4. Ethyl-3,4-dihydroxybenzoate inhibits myoblast differentiation: evidence for an essential role of collagen. Nandan, D., Clarke, E.P., Ball, E.H., Sanwal, B.D. J. Cell Biol. (1990) [Pubmed]
  5. Activation of the hypoxia-inducible factor-pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors. Warnecke, C., Griethe, W., Weidemann, A., Jürgensen, J.S., Willam, C., Bachmann, S., Ivashchenko, Y., Wagner, I., Frei, U., Wiesener, M., Eckardt, K.U. FASEB J. (2003) [Pubmed]
  6. cis-4-Hydroxy-L-proline and ethyl-3,4-dihydroxybenzoate prevent myogenesis of C2C12 muscle cells and block MyoD1 and myogenin expression. Saitoh, O., Periasamy, M., Kan, M., Matsuda, R. Exp. Cell Res. (1992) [Pubmed]
  7. Stimulation of collagen synthesis by insulin and proteoglycan accumulation by ascorbate in bovine keratocytes in vitro. Musselmann, K., Kane, B., Alexandrou, B., Hassell, J.R. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  8. Inhibition of prolyl hydroxylation during collagen biosynthesis in human skin fibroblast cultures by ethyl 3,4-dihydroxybenzoate. Majamaa, K., Sasaki, T., Uitto, J. J. Invest. Dermatol. (1987) [Pubmed]
  9. Essential role of collagens for terminal differentiation of preadipocytes. Ibrahimi, A., Bonino, F., Bardon, S., Ailhaud, G., Dani, C. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  10. Autonomous migration of human fetal skin fibroblasts into a denuded area in a cell monolayer is mediated by basic fibroblast growth factor and collagen. Kondo, H., Matsuda, R., Yonezawa, Y. In Vitro Cell. Dev. Biol. Anim. (1993) [Pubmed]
  11. Desferoxamine and ethyl-3,4-dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS. Philipp, S., Cui, L., Ludolph, B., Kelm, M., Schulz, R., Cohen, M.V., Downey, J.M. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  12. The prolyl 4-hydroxylase inhibitor ethyl-3,4-dihydroxybenzoate generates effective iron deficiency in cultured cells. Wang, J., Buss, J.L., Chen, G., Ponka, P., Pantopoulos, K. FEBS Lett. (2002) [Pubmed]
  13. The effects of collagen synthesis inhibitory drugs on somitogenesis and myogenin expression in cultured chick and mouse embryos. Chernoff, E.A., Clarke, D.O., Wallace-Evers, J.L., Hungate-Muegge, L.P., Smith, R.C. Tissue & cell. (2001) [Pubmed]
  14. Identification of an antioxidant, ethyl protocatechuate, in peanut seed testa. Huang, S.C., Yen, G.C., Chang, L.W., Yen, W.J., Duh, P.D. J. Agric. Food Chem. (2003) [Pubmed]
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