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Gene Review

VTN  -  vitronectin

Sus scrofa

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Disease relevance of VTN


High impact information on VTN


Biological context of VTN


Anatomical context of VTN


Associations of VTN with chemical compounds

  • In this study, the complete primary structure of porcine vitronectin was elucidated by cloned cDNA and glycoprotein analyses [8].
  • Reactivity of the antibody which inhibited heparin binding greatly increased upon denaturation of vitronectin, implying that this region is normally inaccessible in the native form of the molecule [11].
  • Linear epitopes for the antibodies were identified using cyanogen bromide and plasmin-derived peptides from vitronectin [11].
  • Dextran sulfate of average molecular mass 500 kDa was more effective than dextran sulfate of average molecular mass 5 kDa, supporting a template mechanism of action of the GAGs, in which VN molecules align on the GAG in a conformation suitable for cross-linking [9].
  • We then theorized that DsrA might use vitronectin as a bridge to bind to human cells, but this hypothesis proved to be untrue as eliminating HaCaT cell binding of vitronectin with a monoclonal antibody specific to integrin alpha(v)beta(5) did not affect the attachment of H. ducreyi to HaCaT cells [10].

Other interactions of VTN

  • Bone sialoprotein (BSP) and osteopontin (OPN) are two major non-collagenous proteins in bone that have similar biochemical properties and can mediate cell attachment through an RGD (Arg-Gly-Asp) motif that recognizes the vitronectin receptor [15].

Analytical, diagnostic and therapeutic context of VTN

  • Oligosaccharides were released from the vitronectin by N-glycosidase F digestion and tagged with 2-aminopyridine, and the pyridylamino-oligosaccharides were fractionated by anion-exchange and reverse-phase HPLC [16].


  1. Extensive complement activation in hereditary porcine membranoproliferative glomerulonephritis type II (porcine dense deposit disease). Jansen, J.H., Høgåsen, K., Mollnes, T.E. Am. J. Pathol. (1993) [Pubmed]
  2. Development of the biologically active Guglielmi detachable coil for the treatment of cerebral aneurysms. Part II: an experimental study in a swine aneurysm model. Murayama, Y., Viñuela, F., Suzuki, Y., Akiba, Y., Ulihoa, A., Duckwiler, G.R., Gobin, Y.P., Vinters, H.V., Iwaki, M., Abe, T. AJNR. American journal of neuroradiology. (1999) [Pubmed]
  3. Expression of integrin alphavbeta3 in pig, dog and cattle. Singh, B., Rawlings, N., Kaur, A. Histol. Histopathol. (2001) [Pubmed]
  4. Evidence for a role of collagen synthesis in arterial smooth muscle cell migration. Rocnik, E.F., Chan, B.M., Pickering, J.G. J. Clin. Invest. (1998) [Pubmed]
  5. Blocking ligand occupancy of the alphaVbeta3 integrin inhibits insulin-like growth factor I signaling in vascular smooth muscle cells. Zheng, B., Clemmons, D.R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  6. A fragment of histidine-rich glycoprotein is a potent inhibitor of tumor vascularization. Olsson, A.K., Larsson, H., Dixelius, J., Johansson, I., Lee, C., Oellig, C., Björk, I., Claesson-Welsh, L. Cancer Res. (2004) [Pubmed]
  7. Differential regulation of phosphoinositide metabolism by alphaVbeta3 and alphaVbeta5 integrins upon smooth muscle cell migration. Paulhe, F., Racaud-Sultan, C., Ragab, A., Albiges-Rizo, C., Chap, H., Iberg, N., Morand, O., Perret, B. J. Biol. Chem. (2001) [Pubmed]
  8. Porcine vitronectin, the most compact form of single-chain vitronectin: the smallest molecular mass among vitronectins was ascribed to deletion and substitution of base pairs, and proteolytic trimming of the peptide. Yoneda, A., Kojima, K., Matsumoto, I., Yamamoto, K., Ogawa, H. J. Biochem. (1996) [Pubmed]
  9. Highly sulfated glycosaminoglycans augment the cross-linking of vitronectin by guinea pig liver transglutaminase. Functional studies of the cross-linked vitronectin multimers. Sane, D.C., Moser, T.L., Parker, C.J., Seiffert, D., Loskutoff, D.J., Greenberg, C.S. J. Biol. Chem. (1990) [Pubmed]
  10. The Haemophilus ducreyi serum resistance antigen DsrA confers attachment to human keratinocytes. Cole, L.E., Kawula, T.H., Toffer, K.L., Elkins, C. Infect. Immun. (2002) [Pubmed]
  11. Relative topography of biologically active domains of human vitronectin. Evidence from monoclonal antibody epitope and denaturation studies. Morris, C.A., Underwood, P.A., Bean, P.A., Sheehan, M., Charlesworth, J.A. J. Biol. Chem. (1994) [Pubmed]
  12. Transient functional expression of alphaVbeta 3 on vascular cells during wound repair. Clark, R.A., Tonnesen, M.G., Gailit, J., Cheresh, D.A. Am. J. Pathol. (1996) [Pubmed]
  13. Extracellular matrix stimulation of guinea pig megakaryocyte proplatelet formation in vitro is mediated through the vitronectin receptor. Leven, R.M., Tablin, F. Exp. Hematol. (1992) [Pubmed]
  14. Spatial and temporal analyses of integrin and Muc-1 expression in porcine uterine epithelium and trophectoderm in vivo. Bowen, J.A., Bazer, F.W., Burghardt, R.C. Biol. Reprod. (1996) [Pubmed]
  15. Bone sialoprotein mRNA expression and ultrastructural localization in fetal porcine calvarial bone: comparisons with osteopontin. Chen, J., McKee, M.D., Nanci, A., Sodek, J. Histochem. J. (1994) [Pubmed]
  16. Structures of the N-linked oligosaccharides on porcine plasma vitronectin. Yoneda, A., Ogawa, H., Matsumoto, I., Ishizuka, I., Hase, S., Seno, N. Eur. J. Biochem. (1993) [Pubmed]
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