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Chemical Compound Review

p-Bromophenol     4-bromophenol

Synonyms: bromophenol-4, PubChem19708, CCRIS 632, CHEMBL57284, SureCN17443, ...
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Disease relevance of NSC4970

  • However, these chemically reactive metabolites are apparently nontoxic because treatments which increase the covalent binding of p-bromophenol in vitro do not cause toxicity in vivo [1].
  • Additional in vivo routes to 3- and 4-bromophenol involve dehydration/aromatization of the 3,4-dihydro-3,4-diol, possibly by way of conjugates; these routes have transient ketonic intermediates [2].

High impact information on NSC4970


Chemical compound and disease context of NSC4970


Biological context of NSC4970


Associations of NSC4970 with other chemical compounds


Gene context of NSC4970


  1. Multiple reactive metabolites derived from bromobenzene. Lau, S.S., Monks, T.J., Gillette, J.R. Drug Metab. Dispos. (1984) [Pubmed]
  2. Pathways of formation of 2-, 3- and 4-bromophenol from bromobenzene. Proposed mechanism for C-S lyase reactions of cysteine conjugates. Lertratanangkoon, K., Horning, E.C., Horning, M.G. Res. Commun. Chem. Pathol. Pharmacol. (1993) [Pubmed]
  3. Early mitochondrial disfunction in bromobenzene treated mice: a possible factor of liver injury. Maellaro, E., Del Bello, B., Casini, A.F., Comporti, M., Ceccarelli, D., Muscatello, U., Masini, A. Biochem. Pharmacol. (1990) [Pubmed]
  4. Diffusion of reactive metabolites out of hepatocytes: studies with bromobenzene. Monks, T.J., Lau, S.S., Gillette, J.R. J. Pharmacol. Exp. Ther. (1984) [Pubmed]
  5. Metabolism of stavudine-5'-[p-bromophenyl methoxyalaninyl phosphate], stampidine, in mice, dogs, and cats. Chen, C.L., Yu, G., Venkatachalam, T.K., Uckun, F.M. Drug Metab. Dispos. (2002) [Pubmed]
  6. Bromobenzene metabolism in vivo and in vitro. The mechanism of 4-bromocatechol formation. Miller, N.E., Thomas, D., Billings, R.E. Drug Metab. Dispos. (1990) [Pubmed]
  7. The role of 4-bromophenol and 4-bromocatechol in bromobenzene covalent binding and toxicity in isolated rat hepatocytes. Dankovic, D.A., Billings, R.E. Toxicol. Appl. Pharmacol. (1985) [Pubmed]
  8. Bromobenzene and p-bromophenol toxicity and covalent binding in vivo. Monks, T.J., Hinson, J.A., Gillette, J.R. Life Sci. (1982) [Pubmed]
  9. Photocatalytic degradation of p-halophenols in TiO2 aqueous suspensions: halogen effect on removal rate, aromatic intermediates and toxicity variations. Lapertot, M., Pichat, P., Parra, S., Guillard, C., Pulgarin, C. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering. (2006) [Pubmed]
  10. Effect of chronic ethanol administration on bromobenzene liver toxicity in the rat. Hétu, C., Dumont, A., Joly, J.G. Toxicol. Appl. Pharmacol. (1983) [Pubmed]
  11. Co-amendment with halogenated compounds enhances anaerobic microbial dechlorination of 1,2,3,4-tetrachlorodibenzo-P-dioxin and 1,2,3,4-tetrachlorodibenzofuran in estuarine sediments. Ahn, Y.B., Häggblom, M.M., Fennell, D.E. Environ. Toxicol. Chem. (2005) [Pubmed]
  12. Crystal structures of cyclomaltohexaose (alpha-cyclodextrin) complexes with p-bromophenol and m-bromophenol. Kamitori, S., Toyama, Y., Matsuzaka, O. Carbohydr. Res. (2001) [Pubmed]
  13. Mechanisms for modification of bromobenzene hepatotoxicity by coadministered toluene and chlorobenzene. Koizumi, A., Sadamoto, T., Naganuma, H., Ikeda, M. Am. J. Ind. Med. (1984) [Pubmed]
  14. Removal of bromophenols from water using industrial wastes as low cost adsorbents. Bhatnagar, A. J. Hazard. Mater. (2007) [Pubmed]
  15. Nephrotoxicity of phenolic bromobenzene metabolites in the mouse. Rush, G.F., Newton, J.F., Maita, K., Kuo, C.H., Hook, J.B. Toxicology (1984) [Pubmed]
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