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Chemical Compound Review

p-Picoline     4-methylpyridine

Synonyms: gamma-Picoline, CHEMBL15544, SureCN12062, ACMC-1BQOX, CCRIS 1723, ...
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High impact information on gamma-Methylpyridine


Biological context of gamma-Methylpyridine

  • The adsorption of alpha-,beta-, and gamma-picoline followed the pseudosecond-order rate kinetics [5].
  • Following exposures of 100 microM 2-, 3-, or 4-methylpyridine, evoked population excitatory postsynaptic potential and population spike responses recorded in the cell body field of hippocampal area CA1 were slowly suppressed over the course of 3 h, whereas no effects on local inhibitory processes or latency of evoked responses were detected [6].
  • These findings establish that particular isomers of picoline N-oxide rapidly upregulate CYP2B or, to a lesser extent, CYP2E1 and implicate CYP2B in the enhanced lipid peroxidation observed in microsomes from rats treated with 3- and 4-picoline N-oxides [7].
  • A series of neurophysiological tests was performed on Long-Evans hooded rats treated with either 2-, 3-, or 4-methylpyridine at dosages of 100 mg/kg, approximately one-half the ip LD50 [8].

Anatomical context of gamma-Methylpyridine

  • This new GST isozyme was isolated from the hepatic cytosol of 4-picoline-treated rabbits and purified to homogeneity using S-hexylglutathione-agarose, CM-Sepharose, and PBE118 chromatofocusing chromatography [9].

Associations of gamma-Methylpyridine with other chemical compounds


Gene context of gamma-Methylpyridine

  • Well defined charge transfer (CT) bands have been observed for complexes of C60 with all the pyridines studied except 4-picoline [10].

Analytical, diagnostic and therapeutic context of gamma-Methylpyridine


  1. NMR parameters and geometries of OHN and ODN hydrogen bonds of pyridine-acid complexes. Limbach, H.H., Pietrzak, M., Sharif, S., Tolstoy, P.M., Shenderovich, I.G., Smirnov, S.N., Golubev, N.S., Denisov, G.S. Chemistry (Weinheim an der Bergstrasse, Germany) (2004) [Pubmed]
  2. DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine, or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines. Kasparkova, J., Marini, V., Najajreh, Y., Gibson, D., Brabec, V. Biochemistry (2003) [Pubmed]
  3. 4-pyridylmethyl, a thiol-protecting group suitable for the partial synthesis of proteins. Rüegg, U.T., Jarvis, D., Rudinger, J. Biochem. J. (1979) [Pubmed]
  4. Laboratory evolution of toluene dioxygenase to accept 4-picoline as a substrate. Sakamoto, T., Joern, J.M., Arisawa, A., Arnold, F.H. Appl. Environ. Microbiol. (2001) [Pubmed]
  5. Removal of alpha-picoline, beta-picoline, and gamma-picoline from synthetic wastewater using low cost activated carbons derived from coconut shell fibers. Mohan, D., Singh, K.P., Ghosh, D. Environ. Sci. Technol. (2005) [Pubmed]
  6. Suppression of hippocampal slice excitability by 2-, 3-, and 4-methylpyridine. Fountain, S.B., Teyler, T.J. Ecotoxicol. Environ. Saf. (2001) [Pubmed]
  7. Induction of cytochromes P450 2B and 2E1 in rat liver by isomeric picoline N-oxides. Murray, M., Sefton, R.M., Martini, R., Butler, A.M. Toxicol. Lett. (1997) [Pubmed]
  8. Neurophysiological consequences of acute exposure to methylpyridines. Dyer, R.S., Burdette, L.J., Janssen, R., Boyes, W.K. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1985) [Pubmed]
  9. Enhanced expression, purification, and characterization of a novel class alpha glutathione S-transferase isozyme appearing in rabbit hepatic cytosol following treatment with 4-picoline. Primiano, T., Novak, R.F. Toxicol. Appl. Pharmacol. (1992) [Pubmed]
  10. Absorption spectrometric study of molecular complex formation between [60]fullerene and a series of methylated pyridines. Bhattacharya, S., Banerjee, M., Mukherjee, A.K. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. (2002) [Pubmed]
  11. Photoisomerization and photodissociation of aniline and 4-methylpyridine. Tseng, C.M., Dyakov, Y.A., Huang, C.L., Mebel, A.M., Lin, S.H., Lee, Y.T., Ni, C.K. J. Am. Chem. Soc. (2004) [Pubmed]
  12. The expression, purification, crystallization and preliminary X-ray analysis of a subcomplex of the peripheral stalk of ATP synthase from bovine mitochondria. Silvester, J.A., Dickson, V.K., Runswick, M.J., Leslie, A.G., Walker, J.E. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2006) [Pubmed]
  13. Synthesis, crystal structure, magnetic properties and theoretical studies on a one-dimensional polynuclear copper(II) complex [Cu2(mu1,3-SCN)2(mu'1,3-SCN)2(MPyO)2]n. Shi, J.M., Sun, Y.M., Liu, Z., Liu, L.D., Shi, W., Cheng, P. Dalton transactions (Cambridge, England : 2003) (2006) [Pubmed]
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