High impact information on gamma-Methylpyridine

• One correction factor was determined from the known experimental structure of a very strong OHN hydrogen bond between pentachlorophenol and 4-methylpyridine, determined by the neutron diffraction method [1].
• The global modification of mammalian and plasmid DNAs by novel platinum compounds, cis- or trans-[PtCl(2)(NH(3))(Am)], where Am = NH(3), nonplanar heterocycle piperidine, piperazine, or aromatic planar heterocycle 4-picoline, was investigated in cell-free media using various biochemical and biophysical methods [2].
• DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine, or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines [2].
• Cysteine is converted into S-4-pyridylmethylcysteine [Gosden, Stevenson & Young (1972) J. Chem. Soc. Chem Commun. 1123-1124] by 4-pyridylmethyl chloride in aqueous propanol at pH 8 [3].
• The product of the biotransformation of 4-picoline is 3-hydroxy-4-picoline; no cis-diols of 4-picoline were observed [4].

Biological context of gamma-Methylpyridine

• The adsorption of alpha-,beta-, and gamma-picoline followed the pseudosecond-order rate kinetics [5].
• Following exposures of 100 microM 2-, 3-, or 4-methylpyridine, evoked population excitatory postsynaptic potential and population spike responses recorded in the cell body field of hippocampal area CA1 were slowly suppressed over the course of 3 h, whereas no effects on local inhibitory processes or latency of evoked responses were detected [6].
• These findings establish that particular isomers of picoline N-oxide rapidly upregulate CYP2B or, to a lesser extent, CYP2E1 and implicate CYP2B in the enhanced lipid peroxidation observed in microsomes from rats treated with 3- and 4-picoline N-oxides [7].
• A series of neurophysiological tests was performed on Long-Evans hooded rats treated with either 2-, 3-, or 4-methylpyridine at dosages of 100 mg/kg, approximately one-half the ip LD50 [8].

Anatomical context of gamma-Methylpyridine

• This new GST isozyme was isolated from the hepatic cytosol of 4-picoline-treated rabbits and purified to homogeneity using S-hexylglutathione-agarose, CM-Sepharose, and PBE118 chromatofocusing chromatography [9].

Associations of gamma-Methylpyridine with other chemical compounds

• Overall the adsorption of alpha-picoline, beta-picoline, and y-picoline on FAC and ATFAC follow the order FACalpha-picoline < ATFACalpha-picoline < FAC gamma-picoline < ATFACbeta-picoline < FACbeta picoline < ATFAC gamma-picoline [5].

Gene context of gamma-Methylpyridine

• Well defined charge transfer (CT) bands have been observed for complexes of C60 with all the pyridines studied except 4-picoline [10].

Analytical, diagnostic and therapeutic context of gamma-Methylpyridine

• Photoisomerization and photodissociation of aniline and 4-methylpyridine at 193 nm were studied separately using multimass ion imaging techniques [11].
• The morphology and diffraction properties of the crystals of the subcomplex were improved by the presence of thioxane or 4-methylpyridine in the crystallization liquor [12].
• A new one-dimensional polynuclear copper(II) complex [Cu(2)(mu(1,3)-SCN)(2)(mu'(1,3)-SCN)(2)(MPyO)(2)](n)(where MPyO = 4-methylpyridine N-oxide) has been synthesized and its crystal structure determined by X-ray crystallography [13].

References