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Chemical Compound Review

Biotinamide     5-[(1S,2S,5S)-7-oxo-3-thia- 6,8...

Synonyms: biotin amide, CHEBI:16615, CTK8D4634, AR-1G6540, AC1L369O, ...
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Disease relevance of Biotinamide


High impact information on Biotinamide


Biological context of Biotinamide

  • The data obtained also indicate that placing a hydroxymethylene, carboxylate, or acetate alpha to the biotinamide bond is effective in blocking the biotinamide hydrolysis reaction [5].

Anatomical context of Biotinamide


Associations of Biotinamide with other chemical compounds

  • The hydrochloride salt of a new, small molecular weight (M.W. = 286) biotin-containing compound referred to as biotinamide (N-(2-aminoethyl)biotinamide) was compared with biocytin (M.W. = 372) for its use in intracellular labeling of neurons and in neuronal tracing experiments using avidin conjugates for histochemical detection [11].

Gene context of Biotinamide

  • Biotinamide or BDA staining is then visualized using an ABC-diaminobenzidine-Ni method and finally the tissue is immunocytochemically stained using choline acetyltransferase (ChAT) or parvalbumin antibodies and a peroxidase-anti-peroxidase method [12].
  • By using the juxtacellular method, we labeled these cells with biotinamide and determined whether the recorded neurons were TH-IR and contained NPY mRNA [13].

Analytical, diagnostic and therapeutic context of Biotinamide

  • The morphological and physiological characteristics of myenteric neurons in the guinea pig distal colon were determined using Lucifer yellow- or N-(2-aminoethyl) biotinamide-containing microelectrodes and intracellular recording and staining methods [14].
  • Biotinamide, dissolved in an artificial intracellular solution, was applied to the cut ends of the mesenteric nerves and the tissue was maintained in organ culture overnight [9].


  1. Neonatal screening for biotinidase deficiency. Forman, D.T., Bankson, D.D., Highsmith, W.E. Ann. Clin. Lab. Sci. (1992) [Pubmed]
  2. Central respiratory modulation of barosensitive neurones in rat caudal ventrolateral medulla. Mandel, D.A., Schreihofer, A.M. J. Physiol. (Lond.) (2006) [Pubmed]
  3. Neurochemical characterization of extrinsic innervation of the guinea pig rectum. Olsson, C., Costa, M., Brookes, S.J. J. Comp. Neurol. (2004) [Pubmed]
  4. Vesicular glutamate transporter DNPI/VGLUT2 is expressed by both C1 adrenergic and nonaminergic presympathetic vasomotor neurons of the rat medulla. Stornetta, R.L., Sevigny, C.P., Schreihofer, A.M., Rosin, D.L., Guyenet, P.G. J. Comp. Neurol. (2002) [Pubmed]
  5. Biotin reagents for antibody pretargeting. 5. Additional studies of biotin conjugate design to provide biotinidase stability. Wilbur, D.S., Hamlin, D.K., Chyan, M.K., Kegley, B.B., Pathare, P.M. Bioconjug. Chem. (2001) [Pubmed]
  6. Mu-opioid receptors are present in functionally identified sympathoexcitatory neurons in the rat rostral ventrolateral medulla. Aicher, S.A., Schreihofer, A.M., Kraus, J.A., Sharma, S., Milner, T.A., Guyenet, P.G. J. Comp. Neurol. (2001) [Pubmed]
  7. Jaw-muscle spindle afferent pathways to the trigeminal motor nucleus in the rat. Luo, P., Moritani, M., Dessem, D. J. Comp. Neurol. (2001) [Pubmed]
  8. Evidence for glycinergic respiratory neurons: Bötzinger neurons express mRNA for glycinergic transporter 2. Schreihofer, A.M., Stornetta, R.L., Guyenet, P.G. J. Comp. Neurol. (1999) [Pubmed]
  9. Rapid anterograde and retrograde tracing from mesenteric nerve trunks to the guinea-pig small intestine in vitro. Tassicker, B.C., Hennig, G.W., Costa, M., Brookes, S.J. Cell Tissue Res. (1999) [Pubmed]
  10. Transneuronal transport of intracellularly injected biotinamide in primary afferent axons. Luo, P., Dessem, D. Brain Res. Bull. (1996) [Pubmed]
  11. A biotin-containing compound N-(2-aminoethyl)biotinamide for intracellular labeling and neuronal tracing studies: comparison with biocytin. Kita, H., Armstrong, W. J. Neurosci. Methods (1991) [Pubmed]
  12. Elucidation of neuronal circuitry: protocol(s) combining intracellular labeling, neuroanatomical tracing and immunocytochemical methodologies. Luo, P., Haines, A., Dessem, D. Brain Res. Brain Res. Protoc. (2001) [Pubmed]
  13. Location and electrophysiological characterization of rostral medullary adrenergic neurons that contain neuropeptide Y mRNA in rat medulla. Stornetta, R.L., Akey, P.J., Guyenet, P.G. J. Comp. Neurol. (1999) [Pubmed]
  14. Morphology, electrophysiology, and calbindin immunoreactivity of myenteric neurons in the guinea pig distal colon. Tamura, K., Ito, H., Wade, P.R. J. Comp. Neurol. (2001) [Pubmed]
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