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Gene Review

Slc17a6  -  solute carrier family 17 (sodium-dependent...

Mus musculus

Synonyms: 2900073D12Rik, DNPI, Differentiation-associated BNPI, Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter, Dnpi, ...
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Disease relevance of Slc17a6


High impact information on Slc17a6


Anatomical context of Slc17a6

  • We show here that VGLUT1 and VGLUT2 are co-localized in many layers of the young hippocampus [3].
  • There is agreement that the VGLUTs are differentially expressed in brain, and that two isoforms, VGLUT1 and VGLUT2, are localized to excitatory axon terminals in the cerebellar cortex [4].
  • Three transporters (VGLUT1-VGLUT3) are expressed in the mammalian CNS, with partial overlapping expression patterns, and VGLUT2 is the most abundantly expressed paralog in the thalamus, midbrain, and brainstem [5].
  • Double-labeling immunoelectronmicroscopy confirmed the association of VGLUT2 with GLP-1-containing secretory granules [6].
  • We have shown that intestinal L cells express VGLUT2, a VGLUT isoform, which suggests that L cells secrete L-glutamate [6].

Associations of Slc17a6 with chemical compounds

  • Within the RVLM, 79% of the bulbospinal C1 cells contained DNPI/VGLUT2 mRNA [7].
  • DNPI/VGLUT2 mRNA was detected in most of the adrenergic neurons of the C1, C2, and C3 groups (75-80% of TH-ir neurons), in the A2 noradrenergic group (80%), and in vast numbers of area postrema cells [8].
  • In seven barbiturate-anesthetized rats, 16 vasomotor presympathetic neurons were filled with biotinamide and analyzed for the presence of tyrosine hydroxylase immunoreactivity and/or DNPI/VGLUT2 mRNA [7].

Co-localisations of Slc17a6


Other interactions of Slc17a6

  • We consider it possible that expressions of CR with VGLUT1/VGLUT2 and mGluR1alpha(+) with VGLUT1 in the two subsets of vestibulocerebellar UBCs are determined by specific vestibular inputs, carried by groups of primary and/or secondary vestibular afferents [4].
  • Here, we show that CB1 receptors are primarily located on GABAergic (vesicular GABA transporter-positive) and glutamatergic [vesicular glutamate transporter-1 (VGLUT-1)- and VGLUT-2-positive] striatal nerve terminals and are present in the presynaptic active zone, in the postsynaptic density, as well as in the extrasynaptic membrane [10].

Analytical, diagnostic and therapeutic context of Slc17a6


  1. Vesicular glutamate transporter 3 expression identifies glutamatergic amacrine cells in the rodent retina. Johnson, J., Sherry, D.M., Liu, X., Fremeau, R.T., Seal, R.P., Edwards, R.H., Copenhagen, D.R. J. Comp. Neurol. (2004) [Pubmed]
  2. Molecular and functional analysis of a novel neuronal vesicular glutamate transporter. Bai, L., Xu, H., Collins, J.F., Ghishan, F.K. J. Biol. Chem. (2001) [Pubmed]
  3. Synaptic and vesicular co-localization of the glutamate transporters VGLUT1 and VGLUT2 in the mouse hippocampus. Herzog, E., Takamori, S., Jahn, R., Brose, N., Wojcik, S.M. J. Neurochem. (2006) [Pubmed]
  4. Vesicular glutamate transporters VGLUT1 and VGLUT2 define two subsets of unipolar brush cells in organotypic cultures of mouse vestibulocerebellum. Nunzi, M.G., Russo, M., Mugnaini, E. Neuroscience (2003) [Pubmed]
  5. Vesicular glutamate transporter VGLUT2 expression levels control quantal size and neuropathic pain. Moechars, D., Weston, M.C., Leo, S., Callaerts-Vegh, Z., Goris, I., Daneels, G., Buist, A., Cik, M., van der Spek, P., Kass, S., Meert, T., D'Hooge, R., Rosenmund, C., Hampson, R.M. J. Neurosci. (2006) [Pubmed]
  6. Vesicular storage and secretion of L-glutamate from glucagon-like peptide 1-secreting clonal intestinal L cells. Uehara, S., Jung, S.K., Morimoto, R., Arioka, S., Miyaji, T., Juge, N., Hiasa, M., Shimizu, K., Ishimura, A., Otsuka, M., Yamamoto, A., Maechler, P., Moriyama, Y. J. Neurochem. (2006) [Pubmed]
  7. Vesicular glutamate transporter DNPI/VGLUT2 is expressed by both C1 adrenergic and nonaminergic presympathetic vasomotor neurons of the rat medulla. Stornetta, R.L., Sevigny, C.P., Schreihofer, A.M., Rosin, D.L., Guyenet, P.G. J. Comp. Neurol. (2002) [Pubmed]
  8. Vesicular glutamate transporter DNPI/VGLUT2 mRNA is present in C1 and several other groups of brainstem catecholaminergic neurons. Stornetta, R.L., Sevigny, C.P., Guyenet, P.G. J. Comp. Neurol. (2002) [Pubmed]
  9. Absence of synapsin I and II is accompanied by decreases in vesicular transport of specific neurotransmitters. Bogen, I.L., Boulland, J.L., Mariussen, E., Wright, M.S., Fonnum, F., Kao, H.T., Walaas, S.I. J. Neurochem. (2006) [Pubmed]
  10. Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: a combined immunochemical and pharmacological analysis. Köfalvi, A., Rodrigues, R.J., Ledent, C., Mackie, K., Vizi, E.S., Cunha, R.A., Sperlágh, B. J. Neurosci. (2005) [Pubmed]
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