Disease relevance of benzyl ethanoate

• The relative activities against different substrates of the cloned enzymes were, within experimental error, identical to that of wild-type Acinetobacter sp. strain ADP1 grown on either benzyl acetate, benzyl alcohol, or 4-hydroxybenzyl alcohol as the carbon source [1].
• Study results could explain the different toxicity and carcinogenicity responses of benzyl acetate observed in 2-yr chronic gavage and dosed feed studies [2].
• For male and female B6C3F1 mice there was evidence of carcinogenicity, in that benzyl acetate caused an increased incidence of hepatocellular neoplasms (particularly adenomas) and squamous cell neoplasms of the forestomach [3].
• Mean body weights of control and dosed rats and mice were not affected adversely by benzyl acetate [3].
• Significant stimulation of growth of azaserine-induced foci was observed in a 6-month study, and a low but significant incidence of carcinoma in situ was observed in rats fed benzyl acetate in the diet for 2 yr [4].

High impact information on benzyl ethanoate

• Generation of phenylpropanoid pathway-derived volatiles in transgenic plants: rose alcohol acetyltransferase produces phenylethyl acetate and benzyl acetate in petunia flowers [5].
• Glycine modulates the toxicity of benzyl acetate in F344 rats [6].
• Effects of gavage versus dosed feed administration on the toxicokinetics of benzyl acetate in rats and mice [2].
• Percutaneous absorption of benzyl acetate through rat skin in vitro. 3. A comparison with human skin [7].
• The current studies were undertaken to evaluate benzyl acetate alone as an initiator and promoter of carcinogenesis in the pancreas [4].

Chemical compound and disease context of benzyl ethanoate

• The influence of supplemental glycine on benzyl acetate (BA; a compound metabolized via the hippurate pathway)-induced toxicity was investigated [6].

Biological context of benzyl ethanoate

• Studies on benzyl acetate. III. The percutaneous absorption and disposition of [methylene-14C]benzyl acetate in the rat [8].
• The National Toxicology Program (NTP) rat bioassay on benzyl acetate shows an apparent increase in acinar-cell adenomas of the pancreas in male rats [1] [9].
• However, its binding is independent of pH in the range 5-7.5, whereas both V and V/Km for benzyl acetate hydrolysis decrease with decreasing pH in this range [10].

Anatomical context of benzyl ethanoate

• Benzyl acetate was absorbed from the gastrointestinal tract of rats and mice, with approximately 90% of the administered dose recovered as various metabolites in the urine within 24 h [3].
• Poly(vinyl chloride) (PVC) based membranes of zinc-phthalocyanine (ZPC) with hexadecyltrimethylammonium bromide (HTAB) as a cation excluder, and dibutyl phthalate (DBP) and benzyl acetate (BA) as plasticizing solvent mediators were prepared and investigated as a SO4(2-) selective electrode [11].

References