Disease relevance of PROPANOLAMINE

• The results showed that ethylene glycol (EG) was the best CPA with comparatively low toxicity compared to the other six CPAs tested (methanol, 1,3-propanediol, glycerol, 2-amino-1-ethanol, 3-amino-1-propanol 3-methoxy-1 and 2-propanediol) [1].
• EPD and PPA did not increase the hyperglycemia due to procedural stress [2].

High impact information on PROPANOLAMINE

• To enhance the cellular penetration and prevent degradation by cellular nucleases, the TFOs were modified at their 3' ends by either a cholesterol side chain or a propanolamine blocking group [3].
• Similarly, the relative positioning of the acyl- and propanolamine side chains also influences activity, so the distance between carbonyl group and nitrogen atom seems important [4].
• Intravenous injection of these propanolamine derivatives (1 mg/kg) in normotensive Wistar rats induced a transient fall in blood pressure but significantly reduced the heart rate for more than 30 min [5].
• Propranolol and phenyl propanolamine solubilized NDMS, presumably through the formation of mixed micelles, which had a profound effect on the permeation rates of both drug and enhancer [6].
• The Km of diamine oxidase is 10(-6) M for putrescine and 10(-3) M for 3-aminopropanol [7].

Chemical compound and disease context of PROPANOLAMINE

• EPD and PPA blunted the hyperglycemia in fed mice after a 2 g/kg oral glucose challenge; PSD had no effect [2].

Biological context of PROPANOLAMINE

• The 13C- and 31P-NMR spectra and DSC thermograms of unsonicated dispersions consisting of phospholipids of varying methylation stages of the propanolamine head group were investigated [8].

Gene context of PROPANOLAMINE

• Those isomers with different configuration on the center of chirality in the propanolamine side chain showed statistically different PGP-inhibitory activity [9].

References