Disease relevance of Palfium

• Rapidly reversible acute cor pulmonale after intravenous injection of crushed dextromoramide (Palfium) pills [1].

Psychiatry related information on Palfium

• In a clinical case, where drug abuse was denied, it was possible to identify dextromoramide in the hair of the subject [2].
• The administration of the other narcotic analgesics bezitramide, dextromoramide, methadone and morphine produced a dose-related stimulus generalization with the standard fentanyl treatment [3].

High impact information on Palfium

• This study reports the in vitro influence of morphine, dextromoramide, levomoramide, and methionine-enkephalin upon normal human T blood lymphocytes by using the active and total rosette tests [4].
• Simultaneous determination of dextromoramide, propoxyphene and norpropoxyphene in necropsic whole blood by liquid chromatography [5].
• Bay k 8644, intravenously infused at the 2 micrograms X kg-1 X min-1 rate for 30 min, enhanced the inhibition of the atrial specialized tissue as well as the shortening of the atrial muscle ERP during vagal activity, elicited by the injection of dextromoramide into the cisterna magna [6].
• Stereospecific [3H]sufentanil binding, inhibited by dextromoramide, represents 90% of the total binding in membrane preparations of rat brain and spinal cord [7].
• Oxidative determination of dextromoramide (Palfium) in body fluids [8].

Biological context of Palfium

• Pharmacokinetics of dextromoramide in surgical patients [9].
• Tissue distribution of dextromoramide in the rat [10].
• After central restoration of vagal tone by dextromoramide in anesthetized animals, both parameters appeared to lengthen as the heart rate rose [11].

Anatomical context of Palfium

• Dextromoramide was rapidly absorbed from the gastrointestinal tract, with peak plasma levels between 68 and 177 micrograms/L usually achieved within 0.5-4.0 h after dosing [9].
• The pattern of distribution was similar at 15, 30, 60 and 90 min, with the highest concentrations being found in the liver and the myocardium, while other organs were not able to concentrate dextromoramide [10].

Associations of Palfium with other chemical compounds

• The immunoassay had no cross-reactivity with dihydrocodeine, ethylmorphine, 6-monoacetylmorphine, pholcodine, propoxyphene, dextromoramide, dextrometorphan at 1 and 10 mg/L, or codeine, morphine, methadone, and its metabolite EDDP [12].
• Patients were assigned to sedation (S) with midazolam elixir, analgesia (A) with morphine sulphate or combination therapy (C) with dextromoramide and lorazepam [13].
• Determination and pharmacokinetics of dextromoramide in methadone maintenance therapy [14].
• Serum analysis by capillary gas chromatography and mass spectrometry confirmed the presence of dextromoramide (Palfium), methadone, and lidocaine [15].

Gene context of Palfium

• A method for the identification and quantification of dextromoramide in plasma by GC/NPD is presented [16].

Analytical, diagnostic and therapeutic context of Palfium

• Determination of dextromoramide in plasma and whole blood using high-performance liquid chromatography with ultraviolet absorbance detection [17].
• Dextromoramide (Palfium) was given by intravenous injection to a Thoroughbred horse at a dosage of 20 mg and urine was collected 2, 4, 6 and 8 h after drug administration [18].
• Dextromoramide was provided as escape analgesia throughout the study [19].
• The extent of absorption and other pharmacokinetic parameters of dextromoramide following sublingual administration were assessed in five patients receiving chronic opioid analgesia [20].
• Determination of dextromoramide by capillary gas chromatography and electron impact mass spectrometry [21].

References