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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Pulmonary Heart Disease

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Disease relevance of Pulmonary Heart Disease


High impact information on Pulmonary Heart Disease

  • We conclude that STI571 reverses vascular remodeling and cor pulmonale in severe experimental pulmonary hypertension regardless of the initiating stimulus [6].
  • Effects of oral hydralazine on gas exchange in patients with cor pulmonale [7].
  • After 20 mg sublingual nifedipine in 12 men with clinical stable chronic cor pulmonale the mean arterial pressure and systemic vascular resistance fell, cardiac index rose, and mean pulmonary arterial (Ppa) and wedge (Ppaw) pressures, right atrial pressure, and PaO2 remained unchanged [8].
  • Improved haemodynamics but reduced arterial blood oxygenation, at rest and during exercise after long-term oral prazosin therapy in chronic cor pulmonale [9].
  • The aim of this study was therefore to evaluate the haemodynamic and endocrine sequelae of type 1 ANG II receptor blockade in patients with hypoxaemic cor pulmonale [10].

Chemical compound and disease context of Pulmonary Heart Disease


Biological context of Pulmonary Heart Disease


Anatomical context of Pulmonary Heart Disease


Gene context of Pulmonary Heart Disease

  • Rigid spine muscular dystrophy due to SEPN1 mutation presenting as cor pulmonale [25].
  • Plasma levels of beta-thromboglobulin (beta-TG), platelet factor 4(PF4) and platelet aggregation rate (PAR) were measured in remission phase of 15 patients affected with chronic pulmonary heart disease (CPHD). beta-TG, beta-TG/PF4, PF4 and PAR were significantly higher in the patients than in controls (P < 0.01 and 0.05, respectively) [26].
  • These preliminary findings suggest that long-term vasodilator therapy can result in persistent hemodynamic improvement in some patients with cor pulmonale secondary to COPD, although the impact of this form of therapy on survival remains to be clarified [27].
  • Nine patients showed signs suggestive of cor pulmonale upon ECHO; among these patients, 6 had pressure recordings > or = 40 mmHg and 3 had a PSAP between 35 and 40 mmHg; one patient was asymptomatic and 8 showed signs suggestive of PAH upon clinical examination [28].
  • Changes in atrial natriuretic peptide concentrations during intravenous saline infusion in hypoxic cor pulmonale [29].

Analytical, diagnostic and therapeutic context of Pulmonary Heart Disease


  1. Improved recognition of cor pulmonale in patients with severe chronic obstructive pulmonary disease. Himelman, R.B., Struve, S.N., Brown, J.K., Namnum, P., Schiller, N.B. Am. J. Med. (1988) [Pubmed]
  2. Fatal pulmonary hypertension and resolving immune-complex glomerulonephritis in mixed connective tissue disease. A case report and review of the literature. Jones, M.B., Osterholm, R.K., Wilson, R.B., Martin, F.H., Commers, J.R., Bachmayer, J.D. Am. J. Med. (1978) [Pubmed]
  3. The influence of general and case-related experience on primary care treatment decision making. Gruppen, L.D., Wolf, F.M., Van Voorhees, C., Stross, J.K. Arch. Intern. Med. (1988) [Pubmed]
  4. "Crochetage" (notch) on R wave in inferior limb leads: a new independent electrocardiographic sign of atrial septal defect. Heller, J., Hagège, A.A., Besse, B., Desnos, M., Marie, F.N., Guerot, C. J. Am. Coll. Cardiol. (1996) [Pubmed]
  5. Improvement in pulmonary hypertension and hypoxemia during nitric oxide inhalation in a patient with end-stage pulmonary fibrosis. Channick, R.N., Hoch, R.C., Newhart, J.W., Johnson, F.W., Smith, C.M. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  6. Reversal of experimental pulmonary hypertension by PDGF inhibition. Schermuly, R.T., Dony, E., Ghofrani, H.A., Pullamsetti, S., Savai, R., Roth, M., Sydykov, A., Lai, Y.J., Weissmann, N., Seeger, W., Grimminger, F. J. Clin. Invest. (2005) [Pubmed]
  7. Effects of oral hydralazine on gas exchange in patients with cor pulmonale. Miller, M.J., Chappell, T.R., Cook, W., De Olazabal, J.R., Rubin, L.J. Am. J. Med. (1983) [Pubmed]
  8. Nifedipine in chronic cor pulmonale: acute and relatively long-term effects. Mookherjee, S., Ashutosh, K., Dunsky, M., Hill, N., Vardan, S., Smulyan, H., Warner, R. Clin. Pharmacol. Ther. (1988) [Pubmed]
  9. Improved haemodynamics but reduced arterial blood oxygenation, at rest and during exercise after long-term oral prazosin therapy in chronic cor pulmonale. Vik-Mo, H., Walde, N., Jentoft, H., Halvorsen, F.J. Eur. Heart J. (1985) [Pubmed]
  10. Haemodynamic and endocrine effects of type 1 angiotensin II receptor blockade in patients with hypoxaemic cor pulmonale. Kiely, D.G., Cargill, R.I., Wheeldon, N.M., Coutie, W.J., Lipworth, B.J. Cardiovasc. Res. (1997) [Pubmed]
  11. Renal and pulmonary effects of angiotensin converting enzyme inhibition in chronic hypoxic lung disease. Oliver, R.M., Peacock, A.J., Fleming, J.S., Waller, D.G. Thorax (1989) [Pubmed]
  12. Grand mal seizure induced by oral theophylline. Matthay, R.A., Matthay, M.A., Weinberger, M.M. Thorax (1976) [Pubmed]
  13. Almitrine bismesylate and oxygen therapy in hypoxic cor pulmonale. Evans, T.W., Tweney, J., Waterhouse, J.C., Nichol, J., Suggett, A.J., Howard, P. Thorax (1990) [Pubmed]
  14. Total body potassium in cor pulmonale. Howie, A.D., Pack, A.I., Boddy, K., Mahaffey, M. Thorax (1976) [Pubmed]
  15. Short term effect of oxygen on renal haemodynamics in patients with hypoxaemic chronic obstructive airways disease. Baudouin, S.V., Bott, J., Ward, A., Deane, C., Moxham, J. Thorax (1992) [Pubmed]
  16. Heterozygous FZ alpha 1 antitrypsin deficiency associated with severe emphysema and hepatic disease: case report and family study. Kelly, C.P., Tyrrell, D.N., McDonald, G.S., Whitehouse, D.B., Prichard, J.S. Thorax (1989) [Pubmed]
  17. Hemodynamics at rest and during exercise after oral hydralazine in patients with cor pulmonale. Rubin, L.J., Peter, R.H. Am. J. Cardiol. (1981) [Pubmed]
  18. Atrial natriuretic peptide and brain natriuretic peptide in cor pulmonale. Hemodynamic and endocrine effects. Cargill, R.I., Lipworth, B.J. Chest (1996) [Pubmed]
  19. Effects of olmesartan medoxomil as an angiotensin II-receptor blocker in chronic hypoxic rats. Nakamoto, T., Harasawa, H., Akimoto, K., Hirata, H., Kaneko, H., Kaneko, N., Sorimachi, K. Eur. J. Pharmacol. (2005) [Pubmed]
  20. Is there any association between inhaled ipratropium and mortality in patients with COPD and asthma? Ringbaek, T., Viskum, K. Respiratory medicine. (2003) [Pubmed]
  21. The rigid spine syndrome: a vacuolar variant. Lotz, B.P., Stübgen, J.P. Muscle Nerve (1993) [Pubmed]
  22. Fatal meningococcal septicemia. Dalldorf, F.G., Jennette, J.C. Arch. Pathol. Lab. Med. (1977) [Pubmed]
  23. Effect of isosorbide dinitrate on hemodynamics and respiration of patients with coronary artery disease and of patients with chronic cor pulmonale. Konietzko, N., Schlehe, H., Härich, B., Matthys, H. Respiration; international review of thoracic diseases. (1975) [Pubmed]
  24. Serum soluble Fas in patients with Schistosomal cor pulmonale. Salama, M., El-Kholy, G., Abd El-Haleem, S., Elzamarany, E., Abou Freikha, M., Elwan, N., El-Masry, M., Al-Bacil, A., Elhendy, A. Respiration; international review of thoracic diseases. (2003) [Pubmed]
  25. Rigid spine muscular dystrophy due to SEPN1 mutation presenting as cor pulmonale. Venance, S.L., Koopman, W.J., Miskie, B.A., Hegele, R.A., Hahn, A.F. Neurology (2005) [Pubmed]
  26. Platelet activation in patients with chronic pulmonary heart disease. Effect of dipyridamole treatment. Zhang, X., Ling, P. Chin. Med. J. (1995) [Pubmed]
  27. Long-term effects of nitrendipine on hemodynamics and oxygen transport in patients with cor pulmonale. Rubin, L.J., Moser, K. Chest (1986) [Pubmed]
  28. Prevalence of pulmonary hypertension in systemic sclerosis. de Azevedo, A.B., Sampaio-Barros, P.D., Torres, R.M., Moreira, C. Clinical and experimental rheumatology. (2005) [Pubmed]
  29. Changes in atrial natriuretic peptide concentrations during intravenous saline infusion in hypoxic cor pulmonale. Stewart, A.G., Bardsley, P.A., Baudouin, S.V., Waterhouse, J.C., Thompson, J.S., Morice, A.H., Howard, P. Thorax (1991) [Pubmed]
  30. Measurement of platelet-activating factor in human blood by high performance thin layer chromatography and its clinical application. Li, H.P., Zhang, R.X. J. Tongji Med. Univ. (1993) [Pubmed]
  31. The usefulness of thallium-201 myocardial perfusion scintigraphy in the diagnosis of chronic cor pulmonale. Kawai, S., Tanaka, N., Sawada, M., Sakaguchi, K., Fujita, K., Shiota, K. Jpn. Circ. J. (1981) [Pubmed]
  32. Cardiovascular disease in the aged: overview of an autopsy series. Matsushita, S., Kuroo, M., Takagi, T., Hou, E., Kuramoto, K. Jpn. Circ. J. (1988) [Pubmed]
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