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Gene Review

Rlbp1  -  retinaldehyde binding protein 1

Mus musculus

Synonyms: 3110056M11Rik, CRALBP, Cellular retinaldehyde-binding protein, Cralbp, Retinaldehyde-binding protein 1
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High impact information on Rlbp1


Biological context of Rlbp1


Anatomical context of Rlbp1

  • Cellular retinaldehyde binding protein in developing retinal astrocytes [7].
  • Immunocytochemical studies showed an increase in the proportion of cells expressing glial cell markers, most of which co-expressed CRALBP, GFAP, and vimentin [6].
  • This study showed that Muller cells in degenerating retinas of RCS rats and rd/rd mice ultimately exhibited decreased immunolabelling for CAC and CRALBP at the more advanced stages of retinopathy, which coincided with the loss of photoreceptors [8].
  • In retinas of 6-week-old RCS rats, Muller cells and their processes were immunolabelled for CRALBP, which spanned from the nerve fiber layer (NFL) through the outer nuclear layer [8].

Associations of Rlbp1 with chemical compounds


Other interactions of Rlbp1


Analytical, diagnostic and therapeutic context of Rlbp1


  1. Visual cycle impairment in cellular retinaldehyde binding protein (CRALBP) knockout mice results in delayed dark adaptation. Saari, J.C., Nawrot, M., Kennedy, B.N., Garwin, G.G., Hurley, J.B., Huang, J., Possin, D.E., Crabb, J.W. Neuron (2001) [Pubmed]
  2. Identification of the endogenous retinoids associated with three cellular retinoid-binding proteins from bovine retina and retinal pigment epithelium. Saari, J.C., Bredberg, L., Garwin, G.G. J. Biol. Chem. (1982) [Pubmed]
  3. RPE65 Is Essential for the Function of Cone Photoreceptors in NRL-Deficient Mice. Wenzel, A., von Lintig, J., Oberhauser, V., Tanimoto, N., Grimm, C., Seeliger, M.W. Invest. Ophthalmol. Vis. Sci. (2007) [Pubmed]
  4. Genetic segregation of brain gene expression identifies retinaldehyde binding protein 1 and syntaxin 12 as potential contributors to ethanol preference in mice. Treadwell, J.A., Pagniello, K.B., Singh, S.M. Behav. Genet. (2004) [Pubmed]
  5. Molecular characterization of the mouse gene encoding cellular retinaldehyde-binding protein. Kennedy, B.N., Huang, J., Saari, J.C., Crabb, J.W. Mol. Vis. (1998) [Pubmed]
  6. Sorbitol causes preferential selection of Muller glial precursors from late retinal progenitor cells in vitro. Zahir, T., Klassen, H., Tomita, M., Young, M.J. Mol. Vis. (2006) [Pubmed]
  7. Cellular retinaldehyde binding protein in developing retinal astrocytes. Johnson, P.T., Geller, S.F., Lewis, G.P., Reese, B.E. Exp. Eye Res. (1997) [Pubmed]
  8. Mullerian glia in dystrophic rodent retinas: an immunocytochemical analysis. Sheedlo, H.J., Jaynes, D., Bolan, A.L., Turner, J.E. Brain Res. Dev. Brain Res. (1995) [Pubmed]
  9. Stage-specific association of apolipoprotein a-I and e in developing mouse retina. Kurumada, S., Onishi, A., Imai, H., Ishii, K., Kobayashi, T., Sato, S.B. Invest. Ophthalmol. Vis. Sci. (2007) [Pubmed]
  10. GFAP promoter drives Müller cell-specific expression in transgenic mice. Kuzmanovic, M., Dudley, V.J., Sarthy, V.P. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  11. Support for a proposed retinoid-processing protein complex in apical retinal pigment epithelium. Bonilha, V.L., Bhattacharya, S.K., West, K.A., Crabb, J.S., Sun, J., Rayborn, M.E., Nawrot, M., Saari, J.C., Crabb, J.W. Exp. Eye Res. (2004) [Pubmed]
  12. Integration between abutting retinas: role of glial structures and associated molecules at the interface. Zhang, Y., Kardaszewska, A.K., van Veen, T., Rauch, U., Perez, M.T. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
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