Gene Review:
VAV3 - vav 3 guanine nucleotide exchange factor
Homo sapiens
Synonyms:
Guanine nucleotide exchange factor VAV3, VAV-3
- Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer. Dong, Z., Liu, Y., Lu, S., Wang, A., Lee, K., Wang, L.H., Revelo, M., Lu, S. Mol. Endocrinol. (2006)
- Differential regulation of TCR-mediated gene transcription by Vav family members. Zakaria, S., Gomez, T.S., Savoy, D.N., McAdam, S., Turner, M., Abraham, R.T., Billadeau, D.D. J. Exp. Med. (2004)
- Vav3 is regulated during the cell cycle and effects cell division. Fujikawa, K., Inoue, Y., Sakai, M., Koyama, Y., Nishi, S., Funada, R., Alt, F.W., Swat, W. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Vav3, a Rho GTPase Guanine Nucleotide Exchange Factor, Increases during Progression to Androgen Independence in Prostate Cancer Cells and Potentiates Androgen Receptor Transcriptional Activity. Lyons, L.S., Burnstein, K.L. Mol. Endocrinol. (2006)
- Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors. Trenkle, T., McClelland, M., Adlkofer, K., Welsh, J. Gene (2000)
- Bovine mammary gene expression profiling using a cDNA microarray enhanced for mammary-specific transcripts. Suchyta, S.P., Sipkovsky, S., Halgren, R.G., Kruska, R., Elftman, M., Weber-Nielsen, M., Vandehaar, M.J., Xiao, L., Tempelman, R.J., Coussens, P.M. Physiol. Genomics (2003)
- Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen. Pearce, A.C., Senis, Y.A., Billadeau, D.D., Turner, M., Watson, S.P., Vigorito, E. J. Biol. Chem. (2004)
- Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76. Charvet, C., Canonigo, A.J., Billadeau, D.D., Altman, A. J. Biol. Chem. (2005)
- Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation. Zeng, L., Sachdev, P., Yan, L., Chan, J.L., Trenkle, T., McClelland, M., Welsh, J., Wang, L.H. Mol. Cell. Biol. (2000)
- Vav proteins, masters of the world of cytoskeleton organization. Hornstein, I., Alcover, A., Katzav, S. Cell. Signal. (2004)
- Osteoclasts: what do they do and how do they do it? Teitelbaum, S.L. Am. J. Pathol. (2007)
- Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity. Yabana, N., Shibuya, M. Oncogene (2002)