Gene Review:
LCP2 - lymphocyte cytosolic protein 2 (SH2 domain...
Homo sapiens
Synonyms:
Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP-76, SLP-76 tyrosine phosphoprotein, SLP76
- Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and phospholipase C gamma 1 are required for NF-kappa B activation and lipid raft recruitment of protein kinase C theta induced by T cell costimulation. Dienz, O., Möller, A., Strecker, A., Stephan, N., Krammer, P.H., Dröge, W., Schmitz, M.L. J. Immunol. (2003)
- The adaptor molecules LAT and SLP-76 are specifically targeted by Yersinia to inhibit T cell activation. Gerke, C., Falkow, S., Chien, Y.H. J. Exp. Med. (2005)
- Intracellular signalling molecules as immunohistochemical markers of normal and neoplastic human leucocytes in routine biopsy samples. Pozzobon, M., Marafioti, T., Hansmann, M.L., Natkunam, Y., Mason, D.Y. Br. J. Haematol. (2004)
- Protein-tyrosine kinases and adaptor proteins in FcepsilonRI-mediated signaling in mast cells. Sada, K., Yamamura, H. Curr. Mol. Med. (2003)
- Loss of SLP-76 Expression within Myeloid Cells Confers Resistance to Neutrophil-Mediated Tissue Damage while Maintaining Effective Bacterial Killing. Clemens, R.A., Lenox, L.E., Kambayashi, T., Bezman, N., Maltzman, J.S., Nichols, K.E., Koretzky, G.A. J. Immunol. (2007)
- Mechanisms of signaling by the hematopoietic-specific adaptor proteins, SLP-76 and LAT and their B cell counterpart, BLNK/SLP-65. Yablonski, D., Weiss, A. Adv. Immunol. (2001)
- Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell. Yablonski, D., Kuhne, M.R., Kadlecek, T., Weiss, A. Science (1998)
- Trichostatin A down-regulates ZAP-70, LAT and SLP-76 content in Jurkat T cells. Januchowski, R., Jagodzinski, P.P. Int. Immunopharmacol. (2007)
- Polymorphism in and localization of the gene LCP2 (SLP-76) to chromosome 5q33.1-qter. Sunden, S.L., Carr, L.L., Clements, J.L., Motto, D.G., Koretzky, G.A. Genomics (1996)
- Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton. Barda-Saad, M., Braiman, A., Titerence, R., Bunnell, S.C., Barr, V.A., Samelson, L.E. Nat. Immunol. (2005)
- Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes. Sauer, K., Liou, J., Singh, S.B., Yablonski, D., Weiss, A., Perlmutter, R.M. J. Biol. Chem. (2001)
- Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells. Schneider, H., Guerette, B., Guntermann, C., Rudd, C.E. J. Biol. Chem. (2000)
- Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76. Charvet, C., Canonigo, A.J., Billadeau, D.D., Altman, A. J. Biol. Chem. (2005)
- Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane. Ishiai, M., Kurosaki, M., Inabe, K., Chan, A.C., Sugamura, K., Kurosaki, T. J. Exp. Med. (2000)
- Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton. Krause, M., Sechi, A.S., Konradt, M., Monner, D., Gertler, F.B., Wehland, J. J. Cell Biol. (2000)
- PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells. Moog-Lutz, C., Peterson, E.J., Lutz, P.G., Eliason, S., Cavé-Riant, F., Singer, A., Di Gioia, Y., Dmowski, S., Kamens, J., Cayre, Y.E., Koretzky, G. J. Biol. Chem. (2001)
- The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton. Obergfell, A., Judd, B.A., del Pozo, M.A., Schwartz, M.A., Koretzky, G.A., Shattil, S.J. J. Biol. Chem. (2001)
- Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAP. Kwon, J., Qu, C.K., Maeng, J.S., Falahati, R., Lee, C., Williams, M.S. EMBO J. (2005)
- Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production. Motto, D.G., Ross, S.E., Wu, J., Hendricks-Taylor, L.R., Koretzky, G.A. J. Exp. Med. (1996)
- GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation. Law, C.L., Ewings, M.K., Chaudhary, P.M., Solow, S.A., Yun, T.J., Marshall, A.J., Hood, L., Clark, E.A. J. Exp. Med. (1999)
- Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT. Yablonski, D., Kadlecek, T., Weiss, A. Mol. Cell. Biol. (2001)
- Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 production. Veale, M., Raab, M., Li, Z., da Silva, A.J., Kraeft, S.K., Weremowicz, S., Morton, C.C., Rudd, C.E. J. Biol. Chem. (1999)
- Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function. Singer, A.L., Bunnell, S.C., Obstfeld, A.E., Jordan, M.S., Wu, J.N., Myung, P.S., Samelson, L.E., Koretzky, G.A. J. Biol. Chem. (2004)
- Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages. Erdreich-Epstein, A., Liu, M., Kant, A.M., Izadi, K.D., Nolta, J.A., Durden, D.L. J. Leukoc. Biol. (1999)
- CD28 signaling via VAV/SLP-76 adaptors: regulation of cytokine transcription independent of TCR ligation. Raab, M., Pfister, S., Rudd, C.E. Immunity (2001)
- A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76. Di Bartolo, V., Montagne, B., Salek, M., Jungwirth, B., Carrette, F., Fourtane, J., Sol-Foulon, N., Michel, F., Schwartz, O., Lehmann, W.D., Acuto, O. J. Exp. Med. (2007)
- Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function. Wardenburg, J.B., Fu, C., Jackman, J.K., Flotow, H., Wilkinson, S.E., Williams, D.H., Johnson, R., Kong, G., Chan, A.C., Findell, P.R. J. Biol. Chem. (1996)
- The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. Liu, S.K., Fang, N., Koretzky, G.A., McGlade, C.J. Curr. Biol. (1999)
- Differential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine phosphatase. Onodera, H., Motto, D.G., Koretzky, G.A., Rothstein, D.M. J. Biol. Chem. (1996)
- FYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cells. Raab, M., Kang, H., da Silva, A., Zhu, X., Rudd, C.E. J. Biol. Chem. (1999)
- Distinct role of ZAP-70 and Src homology 2 domain-containing leukocyte protein of 76 kDa in the prolonged activation of extracellular signal-regulated protein kinase by the stromal cell-derived factor-1 alpha/CXCL12 chemokine. Kremer, K.N., Humphreys, T.D., Kumar, A., Qian, N.X., Hedin, K.E. J. Immunol. (2003)
- Molecular cloning of three cDNAs that encode cysteine proteinases in the digestive gland of the American lobster (Homarus americanus). Laycock, M.V., MacKay, R.M., Di Fruscio, M., Gallant, J.W. FEBS Lett. (1991)
- Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. Jackman, J.K., Motto, D.G., Sun, Q., Tanemoto, M., Turck, C.W., Peltz, G.A., Koretzky, G.A., Findell, P.R. J. Biol. Chem. (1995)
- Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase. Shim, E.K., Moon, C.S., Lee, G.Y., Ha, Y.J., Chae, S.K., Lee, J.R. FEBS Lett. (2004)
- Structural basis for recognition of the T cell adaptor protein SLP-76 by the SH3 domain of phospholipase Cgamma1. Deng, L., Velikovsky, C.A., Swaminathan, C.P., Cho, S., Mariuzza, R.A. J. Mol. Biol. (2005)