Gene Review:
Vav3 - vav 3 oncogene
Mus musculus
Synonyms:
A530094I06Rik, AA986410, Guanine nucleotide exchange factor VAV3, Idd18.1, VAV-3
- Vav3 proto-oncogene deficiency leads to sympathetic hyperactivity and cardiovascular dysfunction. Sauzeau, V., Sevilla, M.A., Rivas-Elena, J.V., de Alava, E., Montero, M.J., López-Novoa, J.M., Bustelo, X.R. Nat. Med. (2006)
- Vav3 regulates osteoclast function and bone mass. Faccio, R., Teitelbaum, S.L., Fujikawa, K., Chappel, J., Zallone, A., Tybulewicz, V.L., Ross, F.P., Swat, W. Nat. Med. (2005)
- Global conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3. Llorca, O., Arias-Palomo, E., Zugaza, J.L., Bustelo, X.R. EMBO J. (2005)
- Distinct role of phosphatidylinositol 3-kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes. Sachdev, P., Zeng, L., Wang, L.H. J. Biol. Chem. (2002)
- Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins. Movilla, N., Bustelo, X.R. Mol. Cell. Biol. (1999)
- Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3. Pearce, A.C., McCarty, O.J., Calaminus, S.D., Vigorito, E., Turner, M., Watson, S.P. Biochem. J. (2007)
- Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis. Hunter, S.G., Zhuang, G., Brantley-Sieders, D., Swat, W., Cowan, C.W., Chen, J. Mol. Cell. Biol. (2006)
- Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav. López-Lago, M., Lee, H., Cruz, C., Movilla, N., Bustelo, X.R. Mol. Cell. Biol. (2000)