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Gene Review

est  -  alpha/beta hydrolase

Pseudomonas putida KT2440

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Disease relevance of est

  • This method allowed identification of Pseudomonas putida NRRL B-18435 as a source of this activity and the cloning of a new esterase gene, estZ [1].
  • Although the E. coli genome encodes several proteins with esterase activity, neither wild-type strains nor KO11 contained significant ethyl acetate esterase activity [1].

High impact information on est


Chemical compound and disease context of est


Biological context of est


Associations of est with chemical compounds

  • This was then metabolized to pyruvate; the other product was presumed to be the 4-methyl ester of oxalacetic acid, for which cell extracts contained an inducible, specific esterase [7].

Analytical, diagnostic and therapeutic context of est


  1. Decreasing the level of ethyl acetate in ethanolic fermentation broths of Escherichia coli KO11 by expression of Pseudomonas putida estZ esterase. Hasona, A., York, S.W., Yomano, L.P., Ingram, L.O., Shanmugam, K.T. Appl. Environ. Microbiol. (2002) [Pubmed]
  2. Stereoselective esterase from Pseudomonas putida IFO12996 reveals alpha/beta hydrolase folds for D-beta-acetylthioisobutyric acid synthesis. Elmi, F., Lee, H.T., Huang, J.Y., Hsieh, Y.C., Wang, Y.L., Chen, Y.J., Shaw, S.Y., Chen, C.J. J. Bacteriol. (2005) [Pubmed]
  3. Cloning, heterologous expression, and sequencing of a novel proline iminopeptidase gene, pepI, from Lactobacillus delbrueckii subsp. lactis DSM 7290. Klein, J.R., Schmidt, U., Plapp, R. Microbiology (Reading, Engl.) (1994) [Pubmed]
  4. Identification of a cocaine esterase in a strain of Pseudomonas maltophilia. Britt, A.J., Bruce, N.C., Lowe, C.R. J. Bacteriol. (1992) [Pubmed]
  5. Use of Pseudomonas putida EstA as an anchoring motif for display of a periplasmic enzyme on the surface of Escherichia coli. Yang, T.H., Pan, J.G., Seo, Y.S., Rhee, J.S. Appl. Environ. Microbiol. (2004) [Pubmed]
  6. Nucleotide sequence of the gene for a thermostable esterase from Pseudomonas putida MR-2068. Ozaki, E., Sakimae, A., Numazawa, R. Biosci. Biotechnol. Biochem. (1995) [Pubmed]
  7. Production of methanol from aromatic acids by Pseudomonas putida. Donnelly, M.I., Dagley, S. J. Bacteriol. (1980) [Pubmed]
  8. The use of a novel recombinant heroin esterase in the development of an illicit drugs biosensor. Rathbone, D.A., Holt, P.J., Lowe, C.R., Bruce, N.C. Ann. N. Y. Acad. Sci. (1996) [Pubmed]
  9. Isolation and Characterization of an Alcohol Dehydrogenase Gene from the Octylphenol Polyethoxylate Degrader Pseudomonas putida S-5. Tasaki, Y., Yoshikawa, H., Tamura, H. Biosci. Biotechnol. Biochem. (2006) [Pubmed]
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