The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

Pepc  -  peptidase C

Mus musculus

Synonyms: Dip-1, Pep-3, Pep3
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Pepc

  • In both strains, the virus-inducing loci are on chromosome 1, linked to the Dip-1/isozyme locus, but the two may not be at allelic sites [1].
  • Linkage studies indicate that gld is located between Pep-3 and Lp on chromosome 1 [2].
  • This assignment of the mouse alpha-spectrin gene to mouse chromosome 1 by DNA hybridization strengthens the previous identification of the alpha-spectrin locus in mouse with the sph locus, which previously was mapped by linkage analysis to mouse chromosome 1, distal to the Pep-3 locus [3].
  • The implied change from heterozygosity to homozygosity that the variant has undergone with respect to H-2:Tla was not paralleled by a similar change at the three other loci tested, since the variant retained heterozygosity for Pep-3 (chromosome 1), Gpi-1 (chromosome 7), and Es-1 (chromosome 8) [4].
  • Recombination between Rnr, a gene that mediates the susceptibility of submaxillary gland renin to induction by androgen, and Dip-1, a chromosome 1 marker, was found in only 1 of 51 recombinant inbred strains, indicating that the two genes are closely linked on chromosome 1 [5].

Biological context of Pepc

  • This feature facilitated mapping the jsd gene to the centromeric end of chromosome 1; the gene order is jsd-Isocitrate dehydrogenase-1 (Idh-1)-Peptidase-3 (Pep-3) [6].
  • To generate appropriate strains of mice for the study of these genes, a series of 10 C.D2 congenic strains recombinant across a 28-centimorgan interval of mouse chromosome 1 extending from Idh-1 to Pep-3 were derived from crosses of the C.D2-Idh-1 Pep-3 congenic strain back to BALB/cAn [7].
  • Analysis of a bcl-2 RFLP in a series of bilineal congenic strains (C.D2), developed as a tool for chromosomal mapping studies, revealed linkage of bcl-2 to the Idh-1/Pep-3 region of murine chromosome 1 [8].
  • The tissue distribution, substrate specificity, and heterozygous expression as a monmeric protein suggest homology of the variant peptidase to human PEP-C and mouse Pep-3 (Dip-1) [9].

Anatomical context of Pepc

  • Importantly, several cytokines produced by the T cell clone were severely repressed by ectopic Pep3, and indeed, the production of these cytokines was enhanced by the expression of wild-type NFATx [10].

Other interactions of Pepc

  • Linkage data of Aox-1 with Id-1 and Dip-1 (encoding a kidney peptidase) demonstrated that this gene coincides with or is closely linked to Aox (Watson et al., 1972) [11].
  • Test-cross data show the following gene order and recombination percentages: Dip-1 19.0 +/- 3.8% Lp 7.4 +/- 2.2% Akp-1 [12].
  • The close linkage between the genes Dominant hemimelia (Dh) and peptidase-3 (Pep-3) has been determined in 65 informative matings with the recombination frequency of 3.8% [13].
  • Differences between BALB/cAn and BALB/c. DBA/2 congenic strains which carry less than 1% of the DBA/2 genome indicate that two genes, one on chromosome 1 linked to bcl-2-Pep-3 and the other on chromosome 4 closely linked to Fv-1, affect the efficiency with which the cells repair radiation-induced chromatin damage [14].
  • Analysis of the progeny of an inbred strain cross-positioned Cchl1a3 1.3 cM proximal to the Pep-3 locus on Chr 1 [15].

Analytical, diagnostic and therapeutic context of Pepc


  1. Genetic mapping of xenotropic leukemia virus-inducing loci in two mouse strains. Kozak, C., Rowe, W.P. Science (1978) [Pubmed]
  2. A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice. Roths, J.B., Murphy, E.D., Eicher, E.M. J. Exp. Med. (1984) [Pubmed]
  3. The alpha-spectrin gene is on chromosome 1 in mouse and man. Huebner, K., Palumbo, A.P., Isobe, M., Kozak, C.A., Monaco, S., Rovera, G., Croce, C.M., Curtis, P.J. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  4. Genomic constitution of an H-2:Tla variant leukemia. Shen, F.W., Chaganti, R.S., Doucette, L.A., Litman, G.W., Steinmetz, M., Hood, L., Boyse, E.A. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  5. Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse. Wilson, C.M., Erdös, E.G., Wilson, J.D., Taylor, B.A. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  6. Juvenile spermatogonial depletion (jsd): a genetic defect of germ cell proliferation of male mice. Beamer, W.G., Cunliffe-Beamer, T.L., Shultz, K.L., Langley, S.H., Roderick, T.H. Biol. Reprod. (1988) [Pubmed]
  7. Construction of a series of congenic mice with recombinant chromosome 1 regions surrounding the genetic loci for resistance to intracellular parasites (Ity, Lsh, and Bcg), DNA repair responses (Rep-1), and the cytoskeletal protein villin (Vil). Mock, B.A., Holiday, D.L., Cerretti, D.P., Darnell, S.C., O'Brien, A.D., Potter, M. Infect. Immun. (1994) [Pubmed]
  8. Mapping of the bcl-2 oncogene on mouse chromosome 1. Mock, B.A., Givol, D., D'Hoostelaere, L.A., Huppi, K., Seldin, M.F., Gurfinkel, N., Unger, T., Potter, M., Mushinski, J.F. Cytogenet. Cell Genet. (1988) [Pubmed]
  9. Peptidase-3 (Pep-3), dipeptidase variant in the rat homologous to mouse pep-3 (Dip-1) and human PEP-c. Womack, J.E., Cramer, D.V. Biochem. Genet. (1980) [Pubmed]
  10. Inhibition of NFATx activation by an oligopeptide: disrupting the interaction of NFATx with calcineurin. Liu, J., Arai , K., Arai, N. J. Immunol. (2001) [Pubmed]
  11. Genetics, ontogeny, and testosterone inducibility of aldehyde oxidase isozymes in the mouse: evidence for two genetic loci (Aox-I and Aox-2) closely linked on chromosome 1. Holmes, R.S. Biochem. Genet. (1979) [Pubmed]
  12. Genetic variation in alkaline phosphatase of the house mouse (Mus musculus) with emphasis on a manganese-requiring isozyme. Wilcox, F.H., Hirschhorn, L., Taylor, B.A., Womack, J.E., Roderick, T.H. Biochem. Genet. (1979) [Pubmed]
  13. Identification of Dh/+ and Dh/Dh embryos through close linkage of Dh and peptidase-3. Holmes, L.B. Teratology (1986) [Pubmed]
  14. Genes on chromosomes 1 and 4 in the mouse are associated with repair of radiation-induced chromatin damage. Potter, M., Sanford, K.K., Parshad, R., Tarone, R.E., Price, F.M., Mock, B., Huppi, K. Genomics (1988) [Pubmed]
  15. The gene for the alpha 1 subunit of the skeletal muscle dihydropyridine-sensitive calcium channel (Cchl1a3) maps to mouse chromosome 1. Chin, H., Krall, M., Kim, H.L., Kozak, C.A., Mock, B. Genomics (1992) [Pubmed]
  16. Genic heterogeneity and genetic monitoring of mouse outbred stocks. Groen, A., Lagerwerf, A.J. Lab. Anim. (1979) [Pubmed]
WikiGenes - Universities