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Gene Review

Aox1  -  aldehyde oxidase 1

Mus musculus

Synonyms: AI196512, AI255253, Aldehyde oxidase 1, Ao, Aox-1, ...
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Disease relevance of Aox1


High impact information on Aox1


Chemical compound and disease context of Aox1

  • Fourteen phosphorylated acetals and aldehydes were synthesized for testing in vitro as inhibitors or substrates of aldehyde oxidase, an enzyme involved in the conversion of aldophosphamide to inactive carboxyphosphamide, and for concurrent in vivo administration with cyclophosphamide to mice bearing L1210 ascites tumor cells [9].
  • We have previously suggested that the recognition of a cross-reactive epitope on the 5-HT4 receptor and the 52-kDa SSA/Ro protein by serotonin-antagonizing autoantibodies could explain the electrophysiological symptoms of congenital heart block in neonatal lupus [10].
  • The novel antidepressant moclobemide is a reversible inhibitor of monoamine oxidase (MAO), preferentially of type A. Moclomide was active in three animal models considered predictive for antidepressant activity: 1) it prevented dose-dependently akinesia and blepharospasm induced in mice and rats by Ro 4-1284, a short-acting amine releasing agent [11].

Biological context of Aox1


Anatomical context of Aox1


Associations of Aox1 with chemical compounds

  • Genetics, ontogeny, and testosterone inducibility of aldehyde oxidase isozymes in the mouse: evidence for two genetic loci (Aox-I and Aox-2) closely linked on chromosome 1 [17].
  • The genetic loci determining the activity of these isozymes (designated Aox-1 and Aox-2, respecitively) are closely linked on chromosome 1 near Id-1 (encoding the soluble isozyme of isocitrate dehydrogenase) [17].
  • Conservation in the position of exon/intron junctions among the mouse AOH1, AOH2, aldehyde oxidase, and xanthine oxidoreductase loci indicates that these genes are derived from the duplication of an ancestral precursor [18].
  • Administration of testosterone propionate (TP) significantly increased the activities of hepatic AO in intact female mice, but not in MSA-treated or hypophysectomized females [19].
  • On the other hand, the AO activities in adult male mice were decreased partially by the administration of estradiol benzoate [19].

Other interactions of Aox1


Analytical, diagnostic and therapeutic context of Aox1


  1. Selective localization of mouse aldehyde oxidase mRNA in the choroid plexus and motor neurons. Bendotti, C., Prosperini, E., Kurosaki, M., Garattini, E., Terao, M. Neuroreport (1997) [Pubmed]
  2. Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli. Huang, D.Y., Furukawa, A., Ichikawa, Y. Arch. Biochem. Biophys. (1999) [Pubmed]
  3. Identification of aldehyde oxidase 1 and aldehyde oxidase homologue 1 as dioxin-inducible genes. Rivera, S.P., Choi, H.H., Chapman, B., Whitekus, M.J., Terao, M., Garattini, E., Hankinson, O. Toxicology (2005) [Pubmed]
  4. A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen. Xue, D., Shi, H., Smith, J.D., Chen, X., Noe, D.A., Cedervall, T., Yang, D.D., Eynon, E., Brash, D.E., Kashgarian, M., Flavell, R.A., Wolin, S.L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  5. Rescue of lethal molybdenum cofactor deficiency by a biosynthetic precursor from Escherichia coli. Schwarz, G., Santamaria-Araujo, J.A., Wolf, S., Lee, H.J., Adham, I.M., Gröne, H.J., Schwegler, H., Sass, J.O., Otte, T., Hänzelmann, P., Mendel, R.R., Engel, W., Reiss, J. Hum. Mol. Genet. (2004) [Pubmed]
  6. An in vivo comparison of oral 5-iodo-2'-deoxyuridine and 5-iodo-2-pyrimidinone-2'-deoxyribose toxicity, pharmacokinetics, and DNA incorporation in athymic mouse tissues and the human colon cancer xenograft, HCT-116. Kinsella, T.J., Kunugi, K.A., Vielhuber, K.A., McCulloch, W., Liu, S.H., Cheng, Y.C. Cancer Res. (1994) [Pubmed]
  7. Restoration of sensitivity to oxazaphosphorines by inhibitors of aldehyde dehydrogenase activity in cultured oxazaphosphorine-resistant L1210 and cross-linking agent-resistant P388 cell lines. Sladek, N.E., Landkamer, G.J. Cancer Res. (1985) [Pubmed]
  8. Avian and canine aldehyde oxidases. Novel insights into the biology and evolution of molybdo-flavoenzymes. Terao, M., Kurosaki, M., Barzago, M.M., Varasano, E., Boldetti, A., Bastone, A., Fratelli, M., Garattini, E. J. Biol. Chem. (2006) [Pubmed]
  9. Cyclophosphamide potentiation and aldehyde oxidase inhibition by phosphorylated aldehydes and acetals. Cates, L.A., Jones, G.S., Good, D.J., Tsai, H.Y., Li, V.S., Caron, N., Tu, S.C., Kimball, A.P. J. Med. Chem. (1980) [Pubmed]
  10. Induction of neonatal lupus in pups of mice immunized with synthetic peptides derived from amino acid sequences of the serotoninergic 5-HT4 receptor. Eftekhari, P., Roegel, J.C., Lezoualc'h, F., Fischmeister, R., Imbs, J.L., Hoebeke, J. Eur. J. Immunol. (2001) [Pubmed]
  11. Pharmacological profile of moclobemide, a short-acting and reversible inhibitor of monoamine oxidase type A. Burkard, W.P., Bonetti, E.P., Da Prada, M., Martin, J.R., Polc, P., Schaffner, R., Scherschlicht, R., Hefti, F., Müller, R.K., Wyss, P.C. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
  12. The aldehyde oxidase gene cluster in mice and rats. Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa. Kurosaki, M., Terao, M., Barzago, M.M., Bastone, A., Bernardinello, D., Salmona, M., Garattini, E. J. Biol. Chem. (2004) [Pubmed]
  13. Genetics and development of ocular oxidases in the mouse: evidence for a new locus (Eox-1) closely linked with the aldehyde oxidase loci on chromosome 1. Hintz, M., Rout, U.K., Holmes, R.S. Anim. Genet. (1988) [Pubmed]
  14. Molecular cloning of the cDNA coding for mouse aldehyde oxidase: tissue distribution and regulation in vivo by testosterone. Kurosaki, M., Demontis, S., Barzago, M.M., Garattini, E., Terao, M. Biochem. J. (1999) [Pubmed]
  15. Fine specificity of the autoimmune response to the Ro/SSA and La/SSB ribonucleoproteins. Scofield, R.H., Farris, A.D., Horsfall, A.C., Harley, J.B. Arthritis Rheum. (1999) [Pubmed]
  16. Inhibition by SKF-525A of the aldehyde oxidase-mediated metabolism of the experimental antitumour agent acridine carboxamide. Robertson, I.G., Bland, T.J. Biochem. Pharmacol. (1993) [Pubmed]
  17. Genetics, ontogeny, and testosterone inducibility of aldehyde oxidase isozymes in the mouse: evidence for two genetic loci (Aox-I and Aox-2) closely linked on chromosome 1. Holmes, R.S. Biochem. Genet. (1979) [Pubmed]
  18. Purification of the aldehyde oxidase homolog 1 (AOH1) protein and cloning of the AOH1 and aldehyde oxidase homolog 2 (AOH2) genes. Identification of a novel molybdo-flavoprotein gene cluster on mouse chromosome 1. Terao, M., Kurosaki, M., Marini, M., Vanoni, M.A., Saltini, G., Bonetto, V., Bastone, A., Federico, C., Saccone, S., Fanelli, R., Salmona, M., Garattini, E. J. Biol. Chem. (2001) [Pubmed]
  19. Involvement of growth hormone as a regulating factor in sex differences of mouse hepatic aldehyde oxidase. Yoshihara, S., Tatsumi, K. Biochem. Pharmacol. (1997) [Pubmed]
  20. A genetic linkage map of rat chromosome 9 with a new locus for variant activity of liver aldehyde oxidase. Kunieda, T., Kobayashi, E., Tachibana, M., Ikadai, H. Exp. Anim. (1999) [Pubmed]
  21. Genetic regulation of alcohol dehydrogenase, aldehyde dehydrogenase and aldehyde oxidase isozymes in the mouse. Holmes, R.S. Adv. Exp. Med. Biol. (1980) [Pubmed]
  22. Genetic variation of some aldehyde-oxidizing enzymes in the mouse. Lush, I.E. Animal blood groups and biochemical genetics. (1978) [Pubmed]
  23. Fine specificities of autoantibodies directed against the Ro, La, Sm, RNP, and Jo-1 proteins defined by two-dimensional gel electrophoresis and immunoblotting. Elkon, K.B., Jankowski, P.W. J. Immunol. (1985) [Pubmed]
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