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MeSH Review

Osteoarthritis, Knee

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Disease relevance of Osteoarthritis, Knee


High impact information on Osteoarthritis, Knee

  • In two independent populations of individuals with knee osteoarthritis, the D14 allele of ASPN is over-represented relative to the common D13 allele, and its frequency increases with disease severity [6].
  • Peptidyl prolyl cis-trans isomerase activity (PPIase) was measured in SF from knee punctures of 26 patients with RA and five patients with knee osteoarthritis (OA) [7].
  • METHODS: We did a randomised, double-blind placebo controlled trial, in which 212 patients with knee osteoarthritis were randomly assigned 1500 mg sulphate oral glucosamine or placebo once daily for 3 years [8].
  • Single, well-designed studies suggest that topically applied capsaicin and laser treatment reduce pain associated with knee osteoarthritis [9].
  • Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA pooling [10].

Chemical compound and disease context of Osteoarthritis, Knee


Biological context of Osteoarthritis, Knee


Anatomical context of Osteoarthritis, Knee


Gene context of Osteoarthritis, Knee


Analytical, diagnostic and therapeutic context of Osteoarthritis, Knee


  1. A case-control study of serum tocopherol levels and the alpha- to gamma-tocopherol ratio in radiographic knee osteoarthritis: the Johnston County Osteoarthritis Project. Jordan, J.M., De Roos, A.J., Renner, J.B., Luta, G., Cohen, A., Craft, N., Helmick, C.G., Hochberg, M.C., Arab, L. Am. J. Epidemiol. (2004) [Pubmed]
  2. Serum cartilage oligomeric matrix protein reflects the presence of clinically diagnosed synovitis in patients with knee osteoarthritis. Vilím, V., Vytásek, R., Olejárová, M., Machácek, S., Gatterová, J., Procházka, B., Kraus, V.B., Pavelka, K. Osteoarthr. Cartil. (2001) [Pubmed]
  3. Correlation between radiographic severity of knee osteoarthritis and future disease progression. Results from a 3-year prospective, placebo-controlled study evaluating the effect of glucosamine sulfate. Bruyere, O., Honore, A., Ethgen, O., Rovati, L.C., Giacovelli, G., Henrotin, Y.E., Seidel, L., Reginster, J.Y. Osteoarthr. Cartil. (2003) [Pubmed]
  4. Serum cartilage oligomeric matrix protein and clinical signs and symptoms of potential pre-radiographic hip and knee pathology. Dragomir, A.D., Kraus, V.B., Renner, J.B., Luta, G., Clark, A., Vilim, V., Hochberg, M.C., Helmick, C.G., Jordan, J.M. Osteoarthr. Cartil. (2002) [Pubmed]
  5. A comparative study of outcome in myositis and other musculoskeletal disorders assessed using the Nottingham health profile. Chung, Y.L., Mitchell, H.L., Houssien, D.A., Al-Mahrouki, H., Carr, A.J., Scott, D.L. Clinical and experimental rheumatology. (2001) [Pubmed]
  6. An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis. Kizawa, H., Kou, I., Iida, A., Sudo, A., Miyamoto, Y., Fukuda, A., Mabuchi, A., Kotani, A., Kawakami, A., Yamamoto, S., Uchida, A., Nakamura, K., Notoya, K., Nakamura, Y., Ikegawa, S. Nat. Genet. (2005) [Pubmed]
  7. Presence of cyclophilin A in synovial fluids of patients with rheumatoid arthritis. Billich, A., Winkler, G., Aschauer, H., Rot, A., Peichl, P. J. Exp. Med. (1997) [Pubmed]
  8. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Reginster, J.Y., Deroisy, R., Rovati, L.C., Lee, R.L., Lejeune, E., Bruyere, O., Giacovelli, G., Henrotin, Y., Dacre, J.E., Gossett, C. Lancet (2001) [Pubmed]
  9. Published trials of nonmedicinal and noninvasive therapies for hip and knee osteoarthritis. Puett, D.W., Griffin, M.R. Ann. Intern. Med. (1994) [Pubmed]
  10. Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA pooling. Spector, T.D., Reneland, R.H., Mah, S., Valdes, A.M., Hart, D.J., Kammerer, S., Langdown, M., Hoyal, C.R., Atienza, J., Doherty, M., Rahman, P., Nelson, M.R., Braun, A. Arthritis Rheum. (2006) [Pubmed]
  11. Efficacy of glucosamine sulfate in knee osteoarthritis: comment on the article by Cibere et al. Möller, I. Arthritis Rheum. (2005) [Pubmed]
  12. Chondroitins 4 and 6 sulfate in osteoarthritis of the knee: a randomized, controlled trial. Michel, B.A., Stucki, G., Frey, D., De Vathaire, F., Vignon, E., Bruehlmann, P., Uebelhart, D. Arthritis Rheum. (2005) [Pubmed]
  13. Use of acetaminophen in alcoholic patients: comment on the 2000 update of the American College of Rheumatology recommendations for management of hip and knee osteoarthritis. Dart, R.C., Kuffner, E.K. Arthritis Rheum. (2001) [Pubmed]
  14. Estrogen use and radiographic osteoarthritis of the knee in women. The Framingham Osteoarthritis Study. Hannan, M.T., Felson, D.T., Anderson, J.J., Naimark, A., Kannel, W.B. Arthritis Rheum. (1990) [Pubmed]
  15. Efficacy and safety of diacerein in osteoarthritis of the knee: a double-blind, placebo-controlled trial. The Diacerein Study Group. Pelletier, J.P., Yaron, M., Haraoui, B., Cohen, P., Nahir, M.A., Choquette, D., Wigler, I., Rosner, I.A., Beaulieu, A.D. Arthritis Rheum. (2000) [Pubmed]
  16. Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy. Clements, K.M., Price, J.S., Chambers, M.G., Visco, D.M., Poole, A.R., Mason, R.M. Arthritis Rheum. (2003) [Pubmed]
  17. Bone mineral density and bone turnover in patients with knee osteoarthritis compared with generalized osteoarthritis. Naitou, K., Kushida, K., Takahashi, M., Ohishi, T., Inoue, T. Calcif. Tissue Int. (2000) [Pubmed]
  18. Interleukin-10G and interleukin-10R microsatellite polymorphisms and osteoarthritis of the knee. Fytili, P., Giannatou, E., Karachalios, T., Malizos, K., Tsezou, A. Clin. Exp. Rheumatol. (2005) [Pubmed]
  19. Multicenter study of hyaluronic acid obtained by biotechnology to evaluate clinical efficacy and safety in knee osteoarthritis. Novaes, A.C., Schaiquevich, P., Nasswetter, G. International journal of clinical pharmacology research. (2005) [Pubmed]
  20. Synovial fluid chondroitin sulphate epitopes 3B3 and 7D4, and glycosaminoglycan in human knee osteoarthritis after exercise. Bautch, J.C., Clayton, M.K., Chu, Q., Johnson, K.A. Ann. Rheum. Dis. (2000) [Pubmed]
  21. Effects of ibuprofen on molecular markers of cartilage and synovium turnover in patients with knee osteoarthritis. Gineyts, E., Mo, J.A., Ko, A., Henriksen, D.B., Curtis, S.P., Gertz, B.J., Garnero, P., Delmas, P.D. Ann. Rheum. Dis. (2004) [Pubmed]
  22. Comparison of endoscopic gastric mucosa features after administration of piroxicam to meloxicam and their correlation with dyspepsia symptoms in elderly patient with knee osteoarthritis. Girawan, D., Abdurachman, S.A., Djumhana, A., Roslia, J., Pramudiyo, R. Acta medica Indonesiana. (2004) [Pubmed]
  23. Association of repeat polymorphisms in the estrogen receptors alpha, beta, and androgen receptor genes with knee osteoarthritis. Fytili, P., Giannatou, E., Papanikolaou, V., Stripeli, F., Karachalios, T., Malizos, K., Tsezou, A. Clin. Genet. (2005) [Pubmed]
  24. Identification of sequence polymorphisms in two sulfation-related genes, PAPSS2 and SLC26A2, and an association analysis with knee osteoarthritis. Ikeda, T., Mabuchi, A., Fukuda, A., Hiraoka, H., Kawakami, A., Yamamoto, S., Machida, H., Takatori, Y., Kawaguchi, H., Nakamura, K., Ikegawa, S. J. Hum. Genet. (2001) [Pubmed]
  25. Serum cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis and knee osteoarthritis. Wisłowska, M., Jabłońska, B. Clin. Rheumatol. (2005) [Pubmed]
  26. Effects of different hyaluronic acid products on synovial fluid levels of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in knee osteoarthritis. Karatay, S., Kiziltunc, A., Yildirim, K., Karanfil, R.C., Senel, K. Ann. Clin. Lab. Sci. (2004) [Pubmed]
  27. Intra-articular injection of somatostatin in knee osteoarthritis: clinical results and IGF-1 serum levels. Silveri, F., Morosini, P., Brecciaroli, D., Cervini, C. International journal of clinical pharmacology research. (1994) [Pubmed]
  28. A comparison of the efficacy and safety of nonsteroidal antiinflammatory agents versus acetaminophen in the treatment of osteoarthritis: a meta-analysis. Lee, C., Straus, W.L., Balshaw, R., Barlas, S., Vogel, S., Schnitzer, T.J. Arthritis Rheum. (2004) [Pubmed]
  29. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Pavelká, K., Gatterová, J., Olejarová, M., Machacek, S., Giacovelli, G., Rovati, L.C. Arch. Intern. Med. (2002) [Pubmed]
  30. Magnetic resonance imaging in osteoarthritis of the knee: correlation with radiographic and scintigraphic findings. McAlindon, T.E., Watt, I., McCrae, F., Goddard, P., Dieppe, P.A. Ann. Rheum. Dis. (1991) [Pubmed]
  31. EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility. Conaghan, P., D'Agostino, M.A., Ravaud, P., Baron, G., Le Bars, M., Grassi, W., Martin-Mola, E., Wakefield, R., Brasseur, J.L., So, A., Backhaus, M., Malaise, M., Burmester, G., Schmidely, N., Emery, P., Dougados, M. Ann. Rheum. Dis. (2005) [Pubmed]
  32. Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a one-year, randomized, double-blind, multicenter study versus placebo. Uebelhart, D., Malaise, M., Marcolongo, R., DeVathaire, F., Piperno, M., Mailleux, E., Fioravanti, A., Matoso, L., Vignon, E. Osteoarthr. Cartil. (2004) [Pubmed]
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