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Gene Review

Vcan  -  versican

Rattus norvegicus

Synonyms: Chondroitin sulfate proteoglycan 2, Chondroitin sulfate proteoglycan core protein 2, Cspg2, GHAP, Glial hyaluronate-binding protein, ...
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Disease relevance of Cspg2

  • The findings suggested that GHAP-negative astrocytes responding to traumatic injury are permissive for axonal growth and that GHAP-positive astrocytes responding to Wallerian degeneration are not permissive [1].
  • Exposure of the cells to hypoxia activated the phosphoglycerate mutase B (PGM-B) gene, resulting in the induction of PGM enzymatic activity, concomitant with elevations of PGM-B mRNA and protein levels [2].

High impact information on Cspg2


Chemical compound and disease context of Cspg2

  • Up-regulation of PGM mRNA by hypoxia was obvious after 8 h exposure, reached its peak after 16 h, persisting for 40 h and returned to the basal level after reoxygenation at 20% O2 for 16 h [2].

Biological context of Cspg2

  • The similarity of HN with PG-M (V3) suggested that HN found in vivo could be the result of an alternative splicing of a single gene [7].

Anatomical context of Cspg2

  • Permissive and non-permissive reactive astrocytes: immunofluorescence study with antibodies to the glial hyaluronate-binding protein [1].
  • Conversely, isomorphic glial scars were still GHAP-positive 3 months after dorsal root transection [1].
  • The distribution of hyaluronate in adult brain white matter and cerebellar cortex was similar to that previously reported for GHAP [8].
  • Conversely, in both dog and rat, GHAP immunoreactivity ceased abruptly in the region of the lamina cribrosa, a sieve-like structure continuous with the sclera through which bundles of optic nerve axons pass [9].
  • Little reactivity was observed in rat cerebral cortex with polyclonal GHAP antibodies if the sections were not incubated with GHAP [10].

Associations of Cspg2 with chemical compounds


Analytical, diagnostic and therapeutic context of Cspg2


  1. Permissive and non-permissive reactive astrocytes: immunofluorescence study with antibodies to the glial hyaluronate-binding protein. Mansour, H., Asher, R., Dahl, D., Labkovsky, B., Perides, G., Bignami, A. J. Neurosci. Res. (1990) [Pubmed]
  2. Hypoxia-induced expression of phosphoglycerate mutase B in fibroblasts. Takahashi, Y., Takahashi, S., Yoshimi, T., Miura, T. Eur. J. Biochem. (1998) [Pubmed]
  3. Versican/PG-M isoforms in vascular smooth muscle cells. Lemire, J.M., Braun, K.R., Maurel, P., Kaplan, E.D., Schwartz, S.M., Wight, T.N. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  4. Effect of hyaluronidase on brain extracellular matrix in vivo and optic nerve regeneration. Tona, A., Bignami, A. J. Neurosci. Res. (1993) [Pubmed]
  5. Versican, a hyaluronate-binding proteoglycan of embryonal precartilaginous mesenchyma, is mainly expressed postnatally in rat brain. Bignami, A., Perides, G., Rahemtulla, F. J. Neurosci. Res. (1993) [Pubmed]
  6. The extracellular matrix of rat spinal cord: a comparative study on the localization of hyaluronic acid, glial hyaluronate-binding protein, and chondroitin sulfate proteoglycan. Bignami, A., Asher, R., Perides, G. Exp. Neurol. (1992) [Pubmed]
  7. Hyaluronectin is produced by oligodendrocytes and Schwann cells in vitro. Courel, M.N., Marret, S., Girard, N., Chauzy, C., Olivier, A., Bertrand, P., Delpech, A., Laquerriere, A., Asou, H., Delpech, B. J. Neurocytol. (1998) [Pubmed]
  8. Some observations on the localization of hyaluronic acid in adult, newborn and embryonal rat brain. Bignami, A., Asher, R. Int. J. Dev. Neurosci. (1992) [Pubmed]
  9. Glial hyaluronate-binding protein (GHAP) in optic nerve and retina. Perides, G., Asher, R., Dahl, D., Bignami, A. Brain Res. (1990) [Pubmed]
  10. Co-localization of hyaluronic acid and chondroitin sulfate proteoglycan in rat cerebral cortex. Bignami, A., Asher, R., Perides, G. Brain Res. (1992) [Pubmed]
  11. Expression of a chondroitin sulfate proteoglycan, versican (PG-M), during development of rat cornea. Koga, T., Inatani, M., Hirata, A., Inomata, Y., Zako, M., Kimata, K., Oohira, A., Gotoh, T., Mori, M., Tanihara, H. Curr. Eye Res. (2005) [Pubmed]
  12. Localization of hyaluronate in primary glial cell cultures derived from newborn rat brain. Asher, R., Bignami, A. Exp. Cell Res. (1991) [Pubmed]
  13. Glial hyaluronate-binding protein expression in aggregating brain cell cultures. Monnet-Tschudi, F., Zurich, M.G., Asher, R., Honegger, P. Dev. Neurosci. (1993) [Pubmed]
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