Gene Review:
VCAN - versican
Homo sapiens
Synonyms:
CSPG2, Chondroitin sulfate proteoglycan 2, Chondroitin sulfate proteoglycan core protein 2, ERVR, GHAP, ...
- Up-regulation of extracellular matrix proteoglycans and collagen type I in human crescentic glomerulonephritis. Stokes, M.B., Hudkins, K.L., Zaharia, V., Taneda, S., Alpers, C.E. Kidney Int. (2001)
- The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican. Cross, N.A., Chandrasekharan, S., Jokonya, N., Fowles, A., Hamdy, F.C., Buttle, D.J., Eaton, C.L. Prostate (2005)
- Proteoglycans in granulomatous lung diseases. Bensadoun, E.S., Burke, A.K., Hogg, J.C., Roberts, C.R. Eur. Respir. J. (1997)
- Immunohistochemical and histochemical characterization of the mucosubstances of odontogenic myxoma: histogenesis and differential diagnosis. Zhao, M., Lu, Y., Takata, T., Ogawa, I., Miyauchi, M., Mock, D., Nikai, H. Pathol. Res. Pract. (1999)
- Structure and regulation of the versican promoter: the versican promoter is regulated by AP-1 and TCF transcription factors in invasive human melanoma cells. Domenzain-Reyna, C., Hernández, D., Miquel-Serra, L., Docampo, M.J., Badenas, C., Fabra, A., Bassols, A. J. Biol. Chem. (2009)
- Versican: a versatile extracellular matrix proteoglycan in cell biology. Wight, T.N. Curr. Opin. Cell Biol. (2002)
- Proteoglycan form of macrophage colony-stimulating factor binds low density lipoprotein. Suzu, S., Inaba, T., Yanai, N., Kawashima, T., Yamada, N., Oka, T., Machinami, R., Ohtsuki, T., Kimura, F., Kondo, S. J. Clin. Invest. (1994)
- Versican is expressed in the proliferating zone in the epidermis and in association with the elastic network of the dermis. Zimmermann, D.R., Dours-Zimmermann, M.T., Schubert, M., Bruckner-Tuderman, L. J. Cell Biol. (1994)
- Isolation and partial characterization of a glial hyaluronate-binding protein. Perides, G., Lane, W.S., Andrews, D., Dahl, D., Bignami, A. J. Biol. Chem. (1989)
- Expression of a wide range of extracellular matrix molecules in the tendon and trochlea of the human superior oblique muscle. Milz, S., Regner, F., Putz, R., Benjamin, M. Invest. Ophthalmol. Vis. Sci. (2002)
- Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification. Toyota, M., Ho, C., Ahuja, N., Jair, K.W., Li, Q., Ohe-Toyota, M., Baylin, S.B., Issa, J.P. Cancer Res. (1999)
- Modulation of prostate cancer cell attachment to matrix by versican. Sakko, A.J., Ricciardelli, C., Mayne, K., Suwiwat, S., LeBaron, R.G., Marshall, V.R., Tilley, W.D., Horsfall, D.J. Cancer Res. (2003)
- Vascular PG-M/versican variants promote platelet adhesion at low shear rates and cooperate with collagens to induce aggregation. Mazzucato, M., Cozzi, M.R., Pradella, P., Perissinotto, D., Malmstrom, A., Morgelin, M., Spessotto, P., Colombatti, A., De Marco, L., Perris, R. FASEB J. (2002)
- Accelerated age-related CpG island methylation in ulcerative colitis. Issa, J.P., Ahuja, N., Toyota, M., Bronner, M.P., Brentnall, T.A. Cancer Res. (2001)
- Mapping of the versican proteoglycan gene (CSPG2) to the long arm of human chromosome 5 (5q12-5q14). Iozzo, R.V., Naso, M.F., Cannizzaro, L.A., Wasmuth, J.J., McPherson, J.D. Genomics (1992)
- Versican interacts with fibrillin-1 and links extracellular microfibrils to other connective tissue networks. Isogai, Z., Aspberg, A., Keene, D.R., Ono, R.N., Reinhardt, D.P., Sakai, L.Y. J. Biol. Chem. (2002)
- beta 1-Integrin-mediated glioma cell adhesion and free radical-induced apoptosis are regulated by binding to a C-terminal domain of PG-M/versican. Wu, Y., Chen, L., Zheng, P.S., Yang, B.B. J. Biol. Chem. (2002)
- Characterization of the complete genomic structure of the human versican gene and functional analysis of its promoter. Naso, M.F., Zimmermann, D.R., Iozzo, R.V. J. Biol. Chem. (1994)
- Differential regulation of extracellular matrix proteoglycan (PG) gene expression. Transforming growth factor-beta 1 up-regulates biglycan (PGI), and versican (large fibroblast PG) but down-regulates decorin (PGII) mRNA levels in human fibroblasts in culture. Kähäri, V.M., Larjava, H., Uitto, J. J. Biol. Chem. (1991)
- Fibulin-1 is a ligand for the C-type lectin domains of aggrecan and versican. Aspberg, A., Adam, S., Kostka, G., Timpl, R., Heinegård, D. J. Biol. Chem. (1999)
- The interaction of versican with its binding partners. Wu, Y.J., La Pierre, D.P., Wu, J., Yee, A.J., Yang, B.B. Cell Res. (2005)
- Biglycan, decorin, and versican protein expression patterns in coronary arteriopathy of human cardiac allograft: distinctness as compared to native atherosclerosis. Lin, H., Wilson, J.E., Roberts, C.R., Horley, K.J., Winters, G.L., Costanzo, M.R., McManus, B.M. J. Heart Lung Transplant. (1996)
- Expression of PG-M(V3), an alternatively spliced form of PG-M without a chondroitin sulfate attachment in region in mouse and human tissues. Zako, M., Shinomura, T., Ujita, M., Ito, K., Kimata, K. J. Biol. Chem. (1995)
- Versican interacts with chemokines and modulates cellular responses. Hirose, J., Kawashima, H., Yoshie, O., Tashiro, K., Miyasaka, M. J. Biol. Chem. (2001)
- Androgen receptor regulation of the versican gene through an androgen response element in the proximal promoter. Read, J.T., Rahmani, M., Boroomand, S., Allahverdian, S., McManus, B.M., Rennie, P.S. J. Biol. Chem. (2007)
- The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding. Olin, A.I., Mörgelin, M., Sasaki, T., Timpl, R., Heinegård, D., Aspberg, A. J. Biol. Chem. (2001)
- Versican-thrombospondin-1 binding in vitro and colocalization in microfibrils induced by inflammation on vascular smooth muscle cells. Kuznetsova, S.A., Issa, P., Perruccio, E.M., Zeng, B., Sipes, J.M., Ward, Y., Seyfried, N.T., Fielder, H.L., Day, A.J., Wight, T.N., Roberts, D.D. J. Cell. Sci. (2006)
- Lipoprotein lipase enhances the binding of native and oxidized low density lipoproteins to versican and biglycan synthesized by cultured arterial smooth muscle cells. Olin, K.L., Potter-Perigo, S., Barrett, P.H., Wight, T.N., Chait, A. J. Biol. Chem. (1999)
- Calcium-dependent self-association of the C-type lectin domain of versican. Ney, A., Booms, P., Epple, G., Mörgelin, M., Guo, G., Kettelgerdes, G., Gessner, R., Robinson, P.N. Int. J. Biochem. Cell Biol. (2006)
- Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4. Sandy, J.D., Westling, J., Kenagy, R.D., Iruela-Arispe, M.L., Verscharen, C., Rodriguez-Mazaneque, J.C., Zimmermann, D.R., Lemire, J.M., Fischer, J.W., Wight, T.N., Clowes, A.W. J. Biol. Chem. (2001)
- Versican protects cells from oxidative stress-induced apoptosis. Wu, Y., Wu, J., Lee, D.Y., Yee, A., Cao, L., Zhang, Y., Kiani, C., Yang, B.B. Matrix Biol. (2005)
- Genistein selectively inhibits platelet-derived growth factor-stimulated versican biosynthesis in monkey arterial smooth muscle cells. Schönherr, E., Kinsella, M.G., Wight, T.N. Arch. Biochem. Biophys. (1997)
- Versican v0 and v1 guide migratory neural crest cells. Dutt, S., Kléber, M., Matasci, M., Sommer, L., Zimmermann, D.R. J. Biol. Chem. (2006)
- Up-regulation of a chondroitin sulphate epitope during regeneration of mouse sciatic nerve: evidence that the immunoreactive molecules are related to the chondroitin sulphate proteoglycans decorin and versican. Braunewell, K.H., Martini, R., LeBaron, R., Kresse, H., Faissner, A., Schmitz, B., Schachner, M. Eur. J. Neurosci. (1995)
- Transforming growth factor-beta as a key molecule triggering the expression of versican isoforms v0 and v1, hyaluronan synthase-2 and synthesis of hyaluronan in malignant osteosarcoma cells. Nikitovic, D., Zafiropoulos, A., Katonis, P., Tsatsakis, A., Theocharis, A.D., Karamanos, N.K., Tzanakakis, G.N. IUBMB Life (2006)
- Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53. Yoon, H., Liyanarachchi, S., Wright, F.A., Davuluri, R., Lockman, J.C., de la Chapelle, A., Pellegata, N.S. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Expression and purification of functionally active hyaluronan-binding domains from human cartilage link protein, aggrecan and versican: formation of ternary complexes with defined hyaluronan oligosaccharides. Seyfried, N.T., McVey, G.F., Almond, A., Mahoney, D.J., Dudhia, J., Day, A.J. J. Biol. Chem. (2005)
- Experimental immunity to the G1 domain of the proteoglycan versican induces spondylitis and sacroiliitis, of a kind seen in human spondylarthropathies. Shi, S., Ciurli, C., Cartman, A., Pidoux, I., Poole, A.R., Zhang, Y. Arthritis Rheum. (2003)