The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Actg1  -  actin, gamma, cytoplasmic 1

Mus musculus

Synonyms: AL023024, Actg, Actin, cytoplasmic 2, Actl, E51, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Actg1


High impact information on Actg1


Chemical compound and disease context of Actg1

  • Human neuroblastoma SH-EP cells transfected with gamma-actin siRNA displayed higher relative resistance to paclitaxel (P<.001), vinblastine (P = .04), and epothilone B (P = .045) than mock-transfected cells [11].

Biological context of Actg1


Anatomical context of Actg1


Associations of Actg1 with chemical compounds


Regulatory relationships of Actg1


Other interactions of Actg1


Analytical, diagnostic and therapeutic context of Actg1

  • Using fluorescent double in situ hybridization we describe the simultaneous intracellular localization of both beta and gamma actin mRNA [24].
  • The Actg gene was mapped to mouse chromosome 6 by Southern blot analysis of DNA isolated from 15 mouse-hamster hybrid cell lines [25].
  • The major cytoskeletal protein, gamma-actin, was down-regulated in the VCR-resistant leukemia xenografts; in contrast, there was no significant change in beta-actin expression [26].
  • A partial sequence analysis of the pME1 insert DNA indicated that it contained a 104-base-pair stretch with extensive homology to the 3' untranslated region of gamma actin [19].
  • DNA from ten mouse genomic clones, each containing distinct gamma-actin processed pseudogenes, was subjected to electron microscopic heteroduplex analysis, and in three cases (lambda mA36, lambda mA118 and lambda mA119) the heteroduplex formed with the DNA of a reference clone was found to be interrupted by a single-stranded loop [27].


  1. cDNA cloning and sequence of a new type of actin in mouse B16 melanoma. Sadano, H., Taniguchi, S., Kakunaga, T., Baba, T. J. Biol. Chem. (1988) [Pubmed]
  2. Noncoding regions of the gamma-actin gene influence the impact of the gene on myoblast morphology. Lloyd, C., Gunning, P. J. Cell Biol. (1993) [Pubmed]
  3. Retroviral and pseudogene insertion sites reveal the lineage of human salivary and pancreatic amylase genes from a single gene during primate evolution. Samuelson, L.C., Wiebauer, K., Snow, C.M., Meisler, M.H. Mol. Cell. Biol. (1990) [Pubmed]
  4. Structure of a processed gene of mouse cytoplasmic gamma-actin transposed into a BAM5 sequence: insertion has created 13 base-pair direct repeats. Tokunaga, K., Yoda, K., Sakiyama, S. Nucleic Acids Res. (1985) [Pubmed]
  5. Differential requirements of gag and gamma-actin domains for transforming potential of Gardner-Rasheed feline sarcoma virus. Miyoshi, J., Miyoshi, Y., Sasai, H., Sakai, N., Katsumata, T., Kakunaga, T. J. Virol. (1989) [Pubmed]
  6. Subcellular sorting of isoactins: selective association of gamma actin with skeletal muscle mitochondria. Pardo, J.V., Pittenger, M.F., Craig, S.W. Cell (1983) [Pubmed]
  7. Decreases in tubulin and actin gene expression prior to morphological differentiation of 3T3 adipocytes. Spiegelman, B.M., Farmer, S.R. Cell (1982) [Pubmed]
  8. Smooth muscle alpha-action is a transformation-sensitive marker for mouse NIH 3T3 and Rat-2 cells. Leavitt, J., Gunning, P., Kedes, L., Jariwalla, R. Nature (1985) [Pubmed]
  9. Endogenous retroviral sequences are required for tissue-specific expression of a human salivary amylase gene. Ting, C.N., Rosenberg, M.P., Snow, C.M., Samuelson, L.C., Meisler, M.H. Genes Dev. (1992) [Pubmed]
  10. The dystrophin complex forms a mechanically strong link between the sarcolemma and costameric actin. Rybakova, I.N., Patel, J.R., Ervasti, J.M. J. Cell Biol. (2000) [Pubmed]
  11. Alterations in gamma-actin and tubulin-targeted drug resistance in childhood leukemia. Verrills, N.M., Po'uha, S.T., Liu, M.L., Liaw, T.Y., Larsen, M.R., Ivery, M.T., Marshall, G.M., Gunning, P.W., Kavallaris, M. J. Natl. Cancer Inst. (2006) [Pubmed]
  12. Identification and developmental expression of a smooth-muscle gamma-actin in postmeiotic male germ cells of mice. Kim, E., Waters, S.H., Hake, L.E., Hecht, N.B. Mol. Cell. Biol. (1989) [Pubmed]
  13. Cytochalasin D-induced actin gene expression in murine erythroleukemia cells. Sympson, C.J., Singleton, D., Geoghegan, T.E. Exp. Cell Res. (1993) [Pubmed]
  14. High level expression of transfected beta- and gamma-actin genes differentially impacts on myoblast cytoarchitecture. Schevzov, G., Lloyd, C., Gunning, P. J. Cell Biol. (1992) [Pubmed]
  15. Mouse cytoskeletal gamma-actin: analysis and implications of the structure of cloned cDNA and processed pseudogenes. Peter, B., Man, Y.M., Begg, C.E., Gall, I., Leader, D.P. J. Mol. Biol. (1988) [Pubmed]
  16. A novel role for non-muscle gamma-actin in skeletal muscle sarcomere assembly. Lloyd, C.M., Berendse, M., Lloyd, D.G., Schevzov, G., Grounds, M.D. Exp. Cell Res. (2004) [Pubmed]
  17. Is gamma-actin a regulator of amino acid transport? Lin, G., McCormick, J.I., Johnstone, R.M. Am. J. Physiol. (1996) [Pubmed]
  18. Specific stimulation of actin gene transcription by epidermal growth factor and cycloheximide. Elder, P.K., Schmidt, L.J., Ono, T., Getz, M.J. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  19. Cell-cycle-specific and serum-dependent expression of gamma-actin mRNA in Swiss mouse 3T3 cells. Masibay, A.S., Qasba, P.K., Sengupta, D.N., Damewood, G.P., Sreevalsan, T. Mol. Cell. Biol. (1988) [Pubmed]
  20. Involvement of gamma and beta actin isoforms in mouse neuroblastoma differentiation. Ulloa, L., Avila, J. Eur. J. Neurosci. (1996) [Pubmed]
  21. Impact of altered actin gene expression on vinculin, talin, cell spreading, and motility. Schevzov, G., Lloyd, C., Gunning, P. DNA Cell Biol. (1995) [Pubmed]
  22. Damage, repair, and mutagenesis in nuclear genes after mouse forebrain ischemia-reperfusion. Liu, P.K., Hsu, C.Y., Dizdaroglu, M., Floyd, R.A., Kow, Y.W., Karakaya, A., Rabow, L.E., Cui, J.K. J. Neurosci. (1996) [Pubmed]
  23. A dual role for poly-ADP-ribosylation in spatial memory acquisition after traumatic brain injury in mice involving NAD+ depletion and ribosylation of 14-3-3gamma. Satchell, M.A., Zhang, X., Kochanek, P.M., Dixon, C.E., Jenkins, L.W., Melick, J., Szabó, C., Clark, R.S. J. Neurochem. (2003) [Pubmed]
  24. Beta and gamma actin mRNAs are differentially located within myoblasts. Hill, M.A., Gunning, P. J. Cell Biol. (1993) [Pubmed]
  25. The mouse smooth muscle gamma actin gene is on chromosome 6. Kim, E., Kwon, Y.K., Trasler, J.M., Kozak, C.A., Hecht, N.B. Somat. Cell Mol. Genet. (1990) [Pubmed]
  26. Proteomic analysis reveals a novel role for the actin cytoskeleton in vincristine resistant childhood leukemia--an in vivo study. Verrills, N.M., Liem, N.L., Liaw, T.Y., Hood, B.D., Lock, R.B., Kavallaris, M. Proteomics (2006) [Pubmed]
  27. Molecular analysis of elements inserted into mouse gamma-actin processed pseudogenes. Man, Y.M., Delius, H., Leader, D.P. Nucleic Acids Res. (1987) [Pubmed]
WikiGenes - Universities