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Adam19  -  a disintegrin and metallopeptidase domain...

Mus musculus

Synonyms: ADAM 19, AL024287, Disintegrin and metalloproteinase domain-containing protein 19, Meltrin-beta, Mltnb
 
 
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Disease relevance of Adam19

 

High impact information on Adam19

 

Biological context of Adam19

 

Anatomical context of Adam19

 

Associations of Adam19 with chemical compounds

  • Treatment of primary osteoblasts with 10 nM calcitriol increased meltrin beta expression more than 3-fold, and both meltrin alpha and meltrin beta expression is apparently regulated in a differentiation-associated manner in a mouse osteoblastic cell line, MC3T3E1 [2].
 

Analytical, diagnostic and therapeutic context of Adam19

  • Northern blot analysis indicates that meltrin beta is widely expressed, with the highest expression in bone, heart, and lung [2].

References

  1. Essential roles of Meltrin beta (ADAM19) in heart development. Kurohara, K., Komatsu, K., Kurisaki, T., Masuda, A., Irie, N., Asano, M., Sudo, K., Nabeshima, Y., Iwakura, Y., Sehara-Fujisawa, A. Dev. Biol. (2004) [Pubmed]
  2. Cloning and initial characterization of mouse meltrin beta and analysis of the expression of four metalloprotease-disintegrins in bone cells. Inoue, D., Reid, M., Lum, L., Krätzschmar, J., Weskamp, G., Myung, Y.M., Baron, R., Blobel, C.P. J. Biol. Chem. (1998) [Pubmed]
  3. Meltrin beta mini, a new ADAM19 isoform lacking metalloprotease and disintegrin domains, induces morphological changes in neuronal cells. Kurisaki, T., Wakatsuki, S., Sehara-Fujisawa, A. FEBS Lett. (2002) [Pubmed]
  4. Spatially- and temporally-restricted expression of meltrin alpha (ADAM12) and beta (ADAM19) in mouse embryo. Kurisaki, T., Masuda, A., Osumi, N., Nabeshima, Y., Fujisawa-Sehara, A. Mech. Dev. (1998) [Pubmed]
  5. Meltrin beta (ADAM19) gene: cloning, mapping, and analysis of the regulatory region. Kurohara, K., Matsuda, Y., Nagabukuro, A., Tsuji, A., Amagasa, T., Fujisawa-Sehara, A. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  6. Meltrin-alpha, a fusion protein involved in multinucleated giant cell and osteoclast formation. Abe, E., Mocharla, H., Yamate, T., Taguchi, Y., Manolagas, S.C. Calcif. Tissue Int. (1999) [Pubmed]
  7. Developmental and hormonal regulation of meltrin beta (ADAM19) expression in mouse testes during embryonic and postnatal life. Bu, S.M., Yang, Y.J., Miao, C.L., Li, H.J., Newcomer, R.G., Sang, Q.X., Duan, E.K. Life Sci. (2006) [Pubmed]
 
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