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Gene Review

Shbg  -  sex hormone binding globulin

Mus musculus

Synonyms: ABP, SBP, SHBG, Sex hormone-binding globulin, Sex steroid-binding protein, ...
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Disease relevance of Shbg

  • Shbg is thus closely linked to several neurological mutations, one of which, Tr, is also associated with male sterility [1].

High impact information on Shbg

  • Both the dephospho form (which blocks binding of GRIP/ABP and PICK1) and the phospho form (which selectively blocks PICK1) attenuated LTD induction by glutamate/depolarization pairing, as did antibodies directed against the PDZ domain of PICK1 [2].
  • Phosphorylation of Ser-880 in this region by PKC differentially regulates the binding of the PDZ domain-containing proteins GRIP/ABP and PICK1 [2].
  • Human actin binding protein (ABP) links specific membrane glycoproteins to cytoskeletal actin microfilaments [3].
  • Allelic variation within the mouse androgen-binding protein (ABP) alpha subunit gene (Abpa) has been suggested to promote assortative mating and thus prezygotic isolation [4].
  • Previous mapping experiments between EL and nonepileptic ABP mice identified, and a congenic strain confirmed, a quantitative trait locus (QTL), El2, which lowered the threshold to seizures induced by gentle rhythmic tossing [5].

Biological context of Shbg


Anatomical context of Shbg


Associations of Shbg with chemical compounds


Regulatory relationships of Shbg

  • Our results indicate that ABP is expressed in the mouse and past failures to detect androgen-binding activity were due to the low level of ABP protein [8].

Other interactions of Shbg

  • Progeny from an intersubspecies backcross were analyzed to position this locus, termed Shbg, between Il-3 and Int-4 in the middle of this chromosome [1].
  • The glands expressing Abp paralogues produce secretions (lacrimal and salivary) or detect odors (MOE and VNO) and thus it appears highly likely that ABP proteins play a role in olfactory communication [15].
  • The extracellular domains of alpha-neurexins are composed of six LNS repeats, named after homologous sequences in the Laminin A G domain, Neurexins, and Sex hormone-binding globulin, with three interspersed epidermal growth factor-like domains [16].

Analytical, diagnostic and therapeutic context of Shbg


  1. Genetic mapping of the gene for androgen-binding protein/sex hormone-binding globulin to mouse chromosome 11. Joseph, D.R., Adamson, M.C., Kozak, C.A. Cytogenet. Cell Genet. (1991) [Pubmed]
  2. Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins. Xia, J., Chung, H.J., Wihler, C., Huganir, R.L., Linden, D.J. Neuron (2000) [Pubmed]
  3. Cloning from the thyroid of a protein related to actin binding protein that is recognized by Graves disease immunoglobulins. Leedman, P.J., Faulkner-Jones, B., Cram, D.S., Harrison, P.J., West, J., O'Brien, E., Simpson, R., Coppel, R.L., Harrison, L.C. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  4. Comparative evolutionary genomics of androgen-binding protein genes. Emes, R.D., Riley, M.C., Laukaitis, C.M., Goodstadt, L., Karn, R.C., Ponting, C.P. Genome Res. (2004) [Pubmed]
  5. A major effect QTL determined by multiple genes in epileptic EL mice. Legare, M.E., Bartlett, F.S., Frankel, W.N. Genome Res. (2000) [Pubmed]
  6. Mouse dioxin-inducible cytosolic aldehyde dehydrogenase-3: AHD4 cDNA sequence, genetic mapping, and differences in mRNA levels. Vasiliou, V., Reuter, S.F., Kozak, C.A., Nebert, D.W. Pharmacogenetics (1993) [Pubmed]
  7. Androgen regulated expression of a spermine binding protein gene in mouse ventral prostate. Mills, J.S., Needham, M., Parker, M.G. Nucleic Acids Res. (1987) [Pubmed]
  8. The androgen-binding protein gene is expressed in CD1 mouse testis. Wang, Y.M., Sullivan, P.M., Petrusz, P., Yarbrough, W., Joseph, D.R. Mol. Cell. Endocrinol. (1989) [Pubmed]
  9. The mouse salivary androgen-binding protein (ABP) gene cluster on Chromosomes 7: characterization and evolutionary relationships. Laukaitis, C.M., Dlouhy, S.R., Karn, R.C. Mamm. Genome (2003) [Pubmed]
  10. Dynamics of testicular germ cell apoptosis in normal mice and transgenic mice overexpressing rat androgen-binding protein. Jeyaraj, D.A., Grossman, G., Petrusz, P. Reprod. Biol. Endocrinol. (2003) [Pubmed]
  11. Repression of the human sex hormone-binding globulin gene in Sertoli cells by upstream stimulatory transcription factors. Selva, D.M., Hogeveen, K.N., Hammond, G.L. J. Biol. Chem. (2005) [Pubmed]
  12. The genes for mouse salivary androgen-binding protein (ABP) subunits alpha and gamma are located on chromosome 7. Dlouhy, S.R., Taylor, B.A., Karn, R.C. Genetics (1987) [Pubmed]
  13. The microevolution of mouse salivary androgen-binding protein (ABP) paralleled subspeciation of Mus musculus. Hwang, J.M., Hofstetter, J.R., Bonhomme, F., Karn, R.C. J. Hered. (1997) [Pubmed]
  14. Production of an antibody to mouse salivary androgen binding protein (ABP) and its use in identifying a prostate protein produced by a gene distinct from Abp. Dlouhy, S.R., Nichols, W.C., Karn, R.C. Biochem. Genet. (1986) [Pubmed]
  15. Diverse spatial, temporal, and sexual expression of recently duplicated androgen-binding protein genes in Mus musculus. Laukaitis, C.M., Dlouhy, S.R., Emes, R.D., Ponting, C.P., Karn, R.C. BMC Evol. Biol. (2005) [Pubmed]
  16. Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit. Missler, M., Hammer, R.E., Südhof, T.C. J. Biol. Chem. (1998) [Pubmed]
  17. Expression and regulation of human sex hormone-binding globulin transgenes in mice during development. Jänne, M., Hogeveen, K.N., Deol, H.K., Hammond, G.L. Endocrinology (1999) [Pubmed]
  18. Alternative ELISA for sex hormone-binding globulin in plasma. Lewis, J.G., Elder, P.A. Clin. Chem. (1998) [Pubmed]
  19. Immunoradiometric assay of sex-hormone binding globulin with use of two different monoclonal antibodies. Gershagen, S., Fernlund, P. Clin. Chem. (1986) [Pubmed]
  20. Ca2+ release by inositol 1,4,5-trisphosphate is blocked by the K(+)-channel blockers apamin and tetrapentylammonium ion, and a monoclonal antibody to a 63 kDa membrane protein: reversal of blockade by K+ ionophores nigericin and valinomycin and purification of the 63 kDa antibody-binding protein. O'Rourke, F., Soons, K., Flaumenhauft, R., Watras, J., Baio-Larue, C., Matthews, E., Feinstein, M.B. Biochem. J. (1994) [Pubmed]
  21. Estrogen receptor beta expression and apoptosis of spermatocytes of mice overexpressing a rat androgen-binding protein transgene. Selva, D.M., Tirado, O.M., Toràn, N., Suárez-Quian, C.A., Reventos, J., Munell, F. Biol. Reprod. (2004) [Pubmed]
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