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Gene Review

Apoa4  -  apolipoprotein A-IV

Mus musculus

Synonyms: Apo-AIV, ApoA-IV, Apoa-4, Apolipoprotein A-IV, Apolipoprotein A4
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Disease relevance of Apoa4


Psychiatry related information on Apoa4


High impact information on Apoa4


Chemical compound and disease context of Apoa4


Biological context of Apoa4


Anatomical context of Apoa4

  • Furthermore, intravenous leptin administration caused a significant 2-fold reduction in the apolipoprotein AIV transcript levels in jejunum 90 min after a fat load [11].
  • Low apolipoprotein A-IV plasma concentrations in men with coronary artery disease [12].

Associations of Apoa4 with chemical compounds

  • Regulation of the apolipoprotein AIV gene expression by estrogen differs in rat and mouse [13].
  • Tryptase predominantly degraded a quantitatively minor subfraction of HDL3 that is lipid poor, exhibits electrophoretic pre-beta mobility, and contains either apolipoprotein A-I or apolipoprotein A-IV as its sole apolipoprotein [14].
  • Apolipoprotein A-IV (apoA-IV) is a 46 kDa glycoprotein that associates with triglyceride-rich and high density lipoproteins [15].

Other interactions of Apoa4


  1. Apolipoprotein A-IV inhibits experimental colitis. Vowinkel, T., Mori, M., Krieglstein, C.F., Russell, J., Saijo, F., Bharwani, S., Turnage, R.H., Davidson, W.S., Tso, P., Granger, D.N., Kalogeris, T.J. J. Clin. Invest. (2004) [Pubmed]
  2. Intestinal maturation in mice lacking CCAAT/enhancer-binding protein alpha (C/EPBalpha). Oesterreicher, T.J., Leeper, L.L., Finegold, M.J., Darlington, G.J., Henning, S.J. Biochem. J. (1998) [Pubmed]
  3. Characterization of the peripheral neuropathy in neonatal and adult mice that are homozygous for the fatty liver dystrophy (fld) mutation. Langner, C.A., Birkenmeier, E.H., Roth, K.A., Bronson, R.T., Gordon, J.I. J. Biol. Chem. (1991) [Pubmed]
  4. Apolipoprotein A-IV serum concentrations are elevated in patients with mild and moderate renal failure. Kronenberg, F., Kuen, E., Ritz, E., König, P., Kraatz, G., Lhotta, K., Mann, J.F., Müller, G.A., Neyer, U., Riegel, W., Riegler, P., Schwenger, V., von Eckardstein, A. J. Am. Soc. Nephrol. (2002) [Pubmed]
  5. Decreased HDL cholesterol levels but normal lipid absorption, growth, and feeding behavior in apolipoprotein A-IV knockout mice. Weinstock, P.H., Bisgaier, C.L., Hayek, T., Aalto-Setala, K., Sehayek, E., Wu, L., Sheiffele, P., Merkel, M., Essenburg, A.D., Breslow, J.L. J. Lipid Res. (1997) [Pubmed]
  6. Mouse apolipoprotein A-IV gene: nucleotide sequence and induction by a high-lipid diet. Williams, S.C., Bruckheimer, S.M., Lusis, A.J., LeBoeuf, R.C., Kinniburgh, A.J. Mol. Cell. Biol. (1986) [Pubmed]
  7. Restriction of apolipoprotein A-IV gene expression to the intestine villus depends on a hormone-responsive element and parallels differential expression of the hepatic nuclear factor 4alpha and gamma isoforms. Sauvaget, D., Chauffeton, V., Citadelle, D., Chatelet, F.P., Cywiner-Golenzer, C., Chambaz, J., Pinçon-Raymond, M., Cardot, P., Le Beyec, J., Ribeiro, A. J. Biol. Chem. (2002) [Pubmed]
  8. Effects of leptin deficiency and short-term repletion on hepatic gene expression in genetically obese mice. Ferrante, A.W., Thearle, M., Liao, T., Leibel, R.L. Diabetes (2001) [Pubmed]
  9. The -700/-310 fragment of the apolipoprotein A-IV gene combined with the -890/-500 apolipoprotein C-III enhancer is sufficient to direct a pattern of gene expression similar to that for the endogenous apolipoprotein A-IV gene. Le Beyec, J., Chauffeton, V., Kan, H.Y., Janvier, P.L., Cywiner-Golenzer, C., Chatelet, F.P., Kalopissis, A.D., Zannis, V., Chambaz, J., Pinçon-Raymond, M., Cardot, P. J. Biol. Chem. (1999) [Pubmed]
  10. Genetic variation in mouse apolipoprotein A-IV due to insertion and deletion in a region of tandem repeats. Reue, K., Leete, T.H. J. Biol. Chem. (1991) [Pubmed]
  11. Leptin action in intestinal cells. Morton, N.M., Emilsson, V., Liu, Y.L., Cawthorne, M.A. J. Biol. Chem. (1998) [Pubmed]
  12. Low apolipoprotein A-IV plasma concentrations in men with coronary artery disease. Kronenberg, F., Stühlinger, M., Trenkwalder, E., Geethanjali, F.S., Pachinger, O., von Eckardstein, A., Dieplinger, H. J. Am. Coll. Cardiol. (2000) [Pubmed]
  13. Regulation of the apolipoprotein AIV gene expression by estrogen differs in rat and mouse. Srivastava, R.A., Kitchens, R.T., Schonfeld, G. Eur. J. Biochem. (1994) [Pubmed]
  14. Mast cell tryptase degrades HDL and blocks its function as an acceptor of cellular cholesterol. Lee, M., Sommerhoff, C.P., von Eckardstein, A., Zettl, F., Fritz, H., Kovanen, P.T. Arterioscler. Thromb. Vasc. Biol. (2002) [Pubmed]
  15. Apolipoprotein A-IV is regulated by nutritional and metabolic stress: involvement of glucocorticoids, HNF-4{alpha}, and PGC-1{alpha}. Hanniman, E.A., Lambert, G., Inoue, Y., Gonzalez, F.J., Sinal, C.J. J. Lipid Res. (2006) [Pubmed]
  16. Apolipoprotein gene polymorphisms as cause of cholesterol QTLs in mice. Suto, J. J. Vet. Med. Sci. (2005) [Pubmed]
  17. Targeted disruption of the apolipoprotein C-III gene in mice results in hypotriglyceridemia and protection from postprandial hypertriglyceridemia. Maeda, N., Li, H., Lee, D., Oliver, P., Quarfordt, S.H., Osada, J. J. Biol. Chem. (1994) [Pubmed]
  18. Growth hormone (GH) receptor knockout mice reveal actions of GH in lung development. Beyea, J.A., Sawicki, G., Olson, D.M., List, E., Kopchick, J.J., Harvey, S. Proteomics (2006) [Pubmed]
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