The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Apoa4  -  apolipoprotein A-IV

Rattus norvegicus

Synonyms: Apo-AIV, ApoA-IV, Apolipoprotein A-IV, Apolipoprotein A4, apoAIV
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Apoa4


Psychiatry related information on Apoa4


High impact information on Apoa4


Biological context of Apoa4


Anatomical context of Apoa4


Associations of Apoa4 with chemical compounds


Physical interactions of Apoa4


Regulatory relationships of Apoa4


Other interactions of Apoa4


Analytical, diagnostic and therapeutic context of Apoa4


  1. Obesity induced by a high-fat diet downregulates apolipoprotein A-IV gene expression in rat hypothalamus. Liu, M., Shen, L., Liu, Y., Woods, S.C., Seeley, R.J., D'Alessio, D., Tso, P. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  2. Ileal lipid infusion stimulates jejunal synthesis of apolipoprotein A-IV without affecting mRNA levels. Kalogeris, T.J., Painter, R.G., Holden, V.R. Proc. Soc. Exp. Biol. Med. (2000) [Pubmed]
  3. Expression of biologically active rat apolipoprotein AIV in Escherichia coli. Liu, M., Maiorano, N., Shen, L., Pearson, K., Tajima, D., Zhang, D.M., Woods, S.C., Seeley, R.J., Davidson, W.S., Tso, P. Physiol. Behav. (2003) [Pubmed]
  4. ApoA-IV is secreted on discrete HDL particles by the rat hepatoma cell line McA-RH7777 transfected with ApoA-IV cDNA. Yao, Z., Lauer, S.J., Sanan, D.A., Fazio, S. Arterioscler. Thromb. (1993) [Pubmed]
  5. Proteomic characterization of rat liver exposed to 2,3,7,8-tetrachlorobenzo-p-dioxin. Lee, S.H., Lee, D.Y., Son, W.K., Joo, W.A., Kim, C.W. J. Proteome Res. (2005) [Pubmed]
  6. Increased apolipoprotein A-IV in rat mesenteric lymph after lipid meal acts as a physiological signal for satiation. Fujimoto, K., Cardelli, J.A., Tso, P. Am. J. Physiol. (1992) [Pubmed]
  7. Altered regulation of apolipoprotein A-IV gene expression in the liver of the genetically obese Zucker rat. Strobl, W., Knerer, B., Gratzl, R., Arbeiter, K., Lin-Lee, Y.C., Patsch, W. J. Clin. Invest. (1993) [Pubmed]
  8. Suppression of food intake by apolipoprotein A-IV is mediated through the central nervous system in rats. Fujimoto, K., Fukagawa, K., Sakata, T., Tso, P. J. Clin. Invest. (1993) [Pubmed]
  9. Mechanism of action of intracisternal apolipoprotein A-IV in inhibiting gastric acid secretion in rats. Okumura, T., Fukagawa, K., Tso, P., Taylor, I.L., Pappas, T.N. Gastroenterology (1995) [Pubmed]
  10. Diurnal rhythm of apolipoprotein A-IV in rat hypothalamus and its relation to food intake and corticosterone. Liu, M., Shen, L., Liu, Y., Tajima, D., Sakai, R., Woods, S.C., Tso, P. Endocrinology (2004) [Pubmed]
  11. Transcriptional regulation of the apolipoprotein A-IV gene involves synergism between a proximal orphan receptor response element and a distant enhancer located in the upstream promoter region of the apolipoprotein C-III gene. Ktistaki, E., Lacorte, J.M., Katrakili, N., Zannis, V.I., Talianidis, I. Nucleic Acids Res. (1994) [Pubmed]
  12. Distribution of apolipoprotein A-IV between the lipoprotein and the lipoprotein-free fractions of rat plasma: possible role of lecithin:cholesterol acyltransferase. DeLamatre, J.G., Hoffmeier, C.A., Lacko, A.G., Roheim, P.S. J. Lipid Res. (1983) [Pubmed]
  13. Apolipoprotein B messenger RNA editing in rat liver: developmental and hormonal modulation is divergent from apolipoprotein A-IV gene expression despite increased hepatic lipogenesis. Inui, Y., Hausman, A.M., Nanthakumar, N., Henning, S.J., Davidson, N.O. J. Lipid Res. (1992) [Pubmed]
  14. Apolipoprotein A-IV stimulates duodenal vagal afferent activity to inhibit gastric motility via a CCK1 pathway. Glatzle, J., Darcel, N., Rechs, A.J., Kalogeris, T.J., Tso, P., Raybould, H.E. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2004) [Pubmed]
  15. Cholestyramine and a fat-free diet lower apolipoprotein A-IV mRNA in jejunum and cholestyramine lowers apolipoprotein A-I mRNA in ileum of rats. Sonoyama, K., Nishikawa, H., Kiriyama, S., Niki, R. J. Nutr. (1994) [Pubmed]
  16. Serum lipids and apolipoproteins in the rat refed after starving: influence of the molecular form of nitrogen (protein, peptides, or free amino acids). Poullain, M.G., Vacher, D., Cezard, J.P., Girard-Globa, A. Metab. Clin. Exp. (1989) [Pubmed]
  17. Role of thyroid hormone in the expression of apolipoprotein A-IV and C-III genes in rat liver. Lin-Lee, Y.C., Strobl, W., Soyal, S., Radosavljevic, M., Song, M., Gotto, A.M., Patsch, W. J. Lipid Res. (1993) [Pubmed]
  18. Isolation and lipid-binding properties of rat apolipoprotein A-IV. Rifici, V.A., Eder, H.A., Swaney, J.B. Biochim. Biophys. Acta (1985) [Pubmed]
  19. Time-related changes in the synthesis and secretion of very low density, low density and high density lipoproteins by cultured rat hepatocytes. Bell-Quint, J., Forte, T. Biochim. Biophys. Acta (1981) [Pubmed]
  20. Effect of simvastatin on the synthesis and secretion of lipoproteins in relation to the metabolism of cholesterol in cultured hepatocytes. Ribeiro, A., Mangeney, M., Loriette, C., Thomas, G., Pepin, D., Janvier, B., Chambaz, J., Bereziat, G. Biochim. Biophys. Acta (1991) [Pubmed]
  21. PYY stimulates synthesis and secretion of intestinal apolipoprotein AIV without affecting mRNA expression. Kalogeris, T.J., Qin, X., Chey, W.Y., Tso, P. Am. J. Physiol. (1998) [Pubmed]
  22. Characterization of serum apolipoprotein patterns in rats during suckling and post-weaning periods. Imaizumi, K., Lu, Y.F., Sugano, M. Biochim. Biophys. Acta (1987) [Pubmed]
  23. Electroimmunoassay of rat apolipoproteins A-I, A-IV, and E. A procedure for sample treatment to increase the sensitivity in diluted fractions. Dallinga-Thie, G.M., Groot, P.H., van Tol, A. J. Lipid Res. (1985) [Pubmed]
  24. ApoA-IV metabolism in the rat: role of lipoprotein lipase and apolipoprotein transfer. Lefevre, M., Chuang, M.Y., Roheim, P.S. J. Lipid Res. (1986) [Pubmed]
  25. Effect of insulin, glucagon or dexamethasone on the production of apolipoprotein A-IV in cultured rat hepatocytes. Uchida, E., Masumoto, A., Sakamoto, S., Koga, S., Nawata, H. Atherosclerosis (1991) [Pubmed]
  26. Effect of leptin on intestinal apolipoprotein AIV in response to lipid feeding. Doi, T., Liu, M., Seeley, R.J., Woods, S.C., Tso, P. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2001) [Pubmed]
  27. Proteolytic processing of the primary translation product of rat intestinal apolipoprotein A-IV mRNA. Comparison with preproapolipoprotein A-I processing. Gordon, J.I., Smith, D.P., Alpers, D.H., Strauss, A.W. J. Biol. Chem. (1982) [Pubmed]
  28. Intravenous infusion of hexamethonium and atropine but not propranolol diminishes apolipoprotein A-IV gene expression in rat ileum. Sonoyama, K., Tajima, K., Fujiwara, R., Kasai, T. J. Nutr. (2000) [Pubmed]
WikiGenes - Universities