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Gene Review

Gjc2  -  gap junction protein, gamma 2

Mus musculus

Synonyms: B230382L12Rik, Connexin-47, Cx47, Gap junction alpha-12 protein, Gap junction gamma-2 protein, ...
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Disease relevance of Gja12

  • Initial analyses of Cx32/Cx47-double-deficient mice showed that these mice developed an action tremor and died on average at 51 d after birth [1].
  • Junctional communication between CNS glia is likely of critical importance because loss of the gap junction channel-forming proteins, connexins Cx32 and Cx47, result in severe demyelination [2].

High impact information on Gja12


Biological context of Gja12


Anatomical context of Gja12


Other interactions of Gja12


Analytical, diagnostic and therapeutic context of Gja12


  1. Connexin 47 (Cx47)-deficient mice with enhanced green fluorescent protein reporter gene reveal predominant oligodendrocytic expression of Cx47 and display vacuolized myelin in the CNS. Odermatt, B., Wellershaus, K., Wallraff, A., Seifert, G., Degen, J., Euwens, C., Fuss, B., Büssow, H., Schilling, K., Steinhäuser, C., Willecke, K. J. Neurosci. (2003) [Pubmed]
  2. Four classes of intercellular channels between glial cells in the CNS. Altevogt, B.M., Paul, D.L. J. Neurosci. (2004) [Pubmed]
  3. Coupling of astrocyte connexins Cx26, Cx30, Cx43 to oligodendrocyte Cx29, Cx32, Cx47: Implications from normal and connexin32 knockout mice. Nagy, J.I., Ionescu, A.V., Lynn, B.D., Rash, J.E. Glia (2003) [Pubmed]
  4. Connexin-47 and connexin-32 in gap junctions of oligodendrocyte somata, myelin sheaths, paranodal loops and Schmidt-Lanterman incisures: implications for ionic homeostasis and potassium siphoning. Kamasawa, N., Sik, A., Morita, M., Yasumura, T., Davidson, K.G., Nagy, J.I., Rash, J.E. Neuroscience (2005) [Pubmed]
  5. Connexin47, connexin29 and connexin32 co-expression in oligodendrocytes and Cx47 association with zonula occludens-1 (ZO-1) in mouse brain. Li, X., Ionescu, A.V., Lynn, B.D., Lu, S., Kamasawa, N., Morita, M., Davidson, K.G., Yasumura, T., Rash, J.E., Nagy, J.I. Neuroscience (2004) [Pubmed]
  6. Functional expression of the new gap junction gene connexin47 transcribed in mouse brain and spinal cord neurons. Teubner, B., Odermatt, B., Guldenagel, M., Sohl, G., Degen, J., Bukauskas, F., Kronengold, J., Verselis, V.K., Jung, Y.T., Kozak, C.A., Schilling, K., Willecke, K. J. Neurosci. (2001) [Pubmed]
  7. Expression of zonula occludens-1 (ZO-1) and the transcription factor ZO-1-associated nucleic acid-binding protein (ZONAB)-MsY3 in glial cells and colocalization at oligodendrocyte and astrocyte gap junctions in mouse brain. Penes, M.C., Li, X., Nagy, J.I. Eur. J. Neurosci. (2005) [Pubmed]
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