Disease relevance of Pdzk1

• The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX) [1].

High impact information on Pdzk1

• Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice [2].
• Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1 [3].
• PDZ domain-containing proteins play an important role in the targeting and localization of synaptic membrane proteins [3].
• Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins [4].
• Phosphorylation of Ser-880 in this region by PKC differentially regulates the binding of the PDZ domain-containing proteins GRIP/ABP and PICK1 [4].

Biological context of Pdzk1

• These include an altered putative S6 transmembrane span, modification of the C-terminal cytoplasmic domain binding site for calmodulin, and generation of two alternate predicted binding sites for PDZ domain-containing proteins [5].

Anatomical context of Pdzk1

• In contrast, NHERF1 abundance increased in the brush border membrane of Pdzk1(-/-) mice fed a high-P(i) diet [6].
• Exploratory reverse transcription-PCR screening revealed mRNAs for several members of PDZ domain-containing proteins in epithelial cells [7].
• Several connexins have recently been reported to interact with the PDZ domain-containing protein zonula occludens-1 (ZO-1), which was originally considered to be associated only with tight junctions, but has recently been reported to associate with other structures including gap junctions in various cell types [8].

Associations of Pdzk1 with chemical compounds

• By co-immunoprecipitation and in vitro binding assays, we establish that the usherin cytodomain can bind to whirlin and harmonin, two PDZ domain-containing proteins that are defective in genetic forms of isolated deafness and USH type I, respectively [9].

Physical interactions of Pdzk1

• RECENT FINDINGS: The PDZ domain-containing adaptor protein PDZK1 has been shown to bind to and control the activity of the high-density lipoprotein receptor SR-BI via a tissue-specific posttranscriptional mechanism [10].

Other interactions of Pdzk1

• Ezrin, moesin, and PDZ-dc1 protein levels were not increased following short term VE [11].
• Glutamate receptor interacting protein (GRIP) is a member of the PDZ domain-containing protein family that is localized in the postsynaptic density area [12].
• The PDZ domain-containing protein zonula occludens-1 (ZO-1) interacts with several members of the connexin (Cx) family of gap junction-forming proteins and has been localized to gap junctions, including those containing Cx47 in oligodendrocytes [13].
• Shank3 is a PDZ domain-containing multidomain protein and is predominantly expressed in developing neurons [14].
• The cytoplasmic carboxy-terminus of NrCAM contains a typical sequence motif for binding to PDZ domains, making interactions with PDZ domain-containing scaffolding proteins quite conceivable [15].

References