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Gene Review

Pdzk1  -  PDZ domain containing 1

Mus musculus

Synonyms: 1700023D20Rik, 2610507N21Rik, 4921513F16Rik, AI267131, AI314638, ...
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Disease relevance of Pdzk1

  • The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX) [1].

High impact information on Pdzk1


Biological context of Pdzk1

  • These include an altered putative S6 transmembrane span, modification of the C-terminal cytoplasmic domain binding site for calmodulin, and generation of two alternate predicted binding sites for PDZ domain-containing proteins [5].

Anatomical context of Pdzk1

  • In contrast, NHERF1 abundance increased in the brush border membrane of Pdzk1(-/-) mice fed a high-P(i) diet [6].
  • Exploratory reverse transcription-PCR screening revealed mRNAs for several members of PDZ domain-containing proteins in epithelial cells [7].
  • Several connexins have recently been reported to interact with the PDZ domain-containing protein zonula occludens-1 (ZO-1), which was originally considered to be associated only with tight junctions, but has recently been reported to associate with other structures including gap junctions in various cell types [8].

Associations of Pdzk1 with chemical compounds

  • By co-immunoprecipitation and in vitro binding assays, we establish that the usherin cytodomain can bind to whirlin and harmonin, two PDZ domain-containing proteins that are defective in genetic forms of isolated deafness and USH type I, respectively [9].

Physical interactions of Pdzk1

  • RECENT FINDINGS: The PDZ domain-containing adaptor protein PDZK1 has been shown to bind to and control the activity of the high-density lipoprotein receptor SR-BI via a tissue-specific posttranscriptional mechanism [10].

Other interactions of Pdzk1


  1. The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX). Sollerbrant, K., Raschperger, E., Mirza, M., Engstrom, U., Philipson, L., Ljungdahl, P.O., Pettersson, R.F. J. Biol. Chem. (2003) [Pubmed]
  2. Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice. Hildebrand, J.D., Soriano, P. Cell (1999) [Pubmed]
  3. Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. Torres, G.E., Yao, W.D., Mohn, A.R., Quan, H., Kim, K.M., Levey, A.I., Staudinger, J., Caron, M.G. Neuron (2001) [Pubmed]
  4. Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins. Xia, J., Chung, H.J., Wihler, C., Huganir, R.L., Linden, D.J. Neuron (2000) [Pubmed]
  5. Structure and complex transcription pattern of the mouse SK1 K(Ca) channel gene, KCNN1. Shmukler, B.E., Bond, C.T., Wilhelm, S., Bruening-Wright, A., Maylie, J., Adelman, J.P., Alper, S.L. Biochim. Biophys. Acta (2001) [Pubmed]
  6. Expression and regulation of the renal Na/phosphate cotransporter NaPi-IIa in a mouse model deficient for the PDZ protein PDZK1. Capuano, P., Bacic, D., Stange, G., Hernando, N., Kaissling, B., Pal, R., Kocher, O., Biber, J., Wagner, C.A., Murer, H. Pflugers Arch. (2005) [Pubmed]
  7. Inhibitory regulation of cystic fibrosis transmembrane conductance regulator anion-transporting activities by Shank2. Kim, J.Y., Han, W., Namkung, W., Lee, J.H., Kim, K.H., Shin, H., Kim, E., Lee, M.G. J. Biol. Chem. (2004) [Pubmed]
  8. Neuronal connexin36 association with zonula occludens-1 protein (ZO-1) in mouse brain and interaction with the first PDZ domain of ZO-1. Li, X., Olson, C., Lu, S., Kamasawa, N., Yasumura, T., Rash, J.E., Nagy, J.I. Eur. J. Neurosci. (2004) [Pubmed]
  9. Usherin, the defective protein in Usher syndrome type IIA, is likely to be a component of interstereocilia ankle links in the inner ear sensory cells. Adato, A., Lefèvre, G., Delprat, B., Michel, V., Michalski, N., Chardenoux, S., Weil, D., El-Amraoui, A., Petit, C. Hum. Mol. Genet. (2005) [Pubmed]
  10. Regulation of SR-BI-mediated high-density lipoprotein metabolism by the tissue-specific adaptor protein PDZK1. Yesilaltay, A., Kocher, O., Rigotti, A., Krieger, M. Curr. Opin. Lipidol. (2005) [Pubmed]
  11. Molecular effects of volume expansion on the renal sodium phosphate cotransporter. Puschett, J.B., Whitbred, J., Ianosi-Irimie, M., Vu, H.V., Rabon, E., Robinson, J., Deininger, P. Am. J. Med. Sci. (2003) [Pubmed]
  12. Differential palmitoylation of two mouse glutamate receptor interacting protein 1 forms with different N-terminal sequences. Yamazaki, M., Fukaya, M., Abe, M., Ikeno, K., Kakizaki, T., Watanabe, M., Sakimura, K. Neurosci. Lett. (2001) [Pubmed]
  13. Expression of zonula occludens-1 (ZO-1) and the transcription factor ZO-1-associated nucleic acid-binding protein (ZONAB)-MsY3 in glial cells and colocalization at oligodendrocyte and astrocyte gap junctions in mouse brain. Penes, M.C., Li, X., Nagy, J.I. Eur. J. Neurosci. (2005) [Pubmed]
  14. Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor. Uchino, S., Wada, H., Honda, S., Nakamura, Y., Ondo, Y., Uchiyama, T., Tsutsumi, M., Suzuki, E., Hirasawa, T., Kohsaka, S. J. Neurochem. (2006) [Pubmed]
  15. The cytoplasmic domain of NrCAM binds to PDZ domains of synapse-associated proteins SAP90/PSD95 and SAP97. Dirks, P., Thomas, U., Montag, D. Eur. J. Neurosci. (2006) [Pubmed]
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