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Atp10a  -  ATPase, class V, type 10A

Mus musculus

Synonyms: ATPase class V type 10A, Atp10c, Atpc5, P-locus fat-associated ATPase, P4-ATPase flippase complex alpha subunit ATP10A, ...
 
 
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Disease relevance of Atp10a

 

High impact information on Atp10a

  • Although sex differences were observed, our data suggest that heterozygous deletion along with an unusual pattern of maternal inheritance of the chromosomal region containing the single gene, Atp10c, causes obesity, type 2 diabetes, and nonalcoholic fatty liver disease in these mice [2].
  • The purpose of this study was to assess the overall effect of the heterozygous deletion of Atp10c on obesity-related phenotypes and metabolic abnormalities in mice fed a high-fat diet [2].
  • Atp10c is a novel type IV P-type ATPase and is a putative phospholipid transporter [2].
  • The mouse Atp10a gene is located at the border of an imprinted domain distal to the p-locus on mouse chromosome 7 [1].
  • These findings suggest that the mouse Atp10a gene escapes genomic imprinting [1].
 

Biological context of Atp10a

  • A putative promoter region of PFATP contains a strong CpG island [3].
  • Full-length cDNA was generated, and the corresponding genomic structure was deduced from the Human Genome Database. RESULTS: Murine pfatp, and its human ortholog, PFATP, belong to class V of the third subfamily of P-type ATPases [3].
 

Anatomical context of Atp10a

 

Associations of Atp10a with chemical compounds

References

  1. Atp10a, the mouse ortholog of the human imprinted ATP10A gene, escapes genomic imprinting. Kayashima, T., Yamasaki, K., Joh, K., Yamada, T., Ohta, T., Yoshiura, K., Matsumoto, N., Nakane, Y., Mukai, T., Niikawa, N., Kishino, T. Genomics (2003) [Pubmed]
  2. Mice heterozygous for Atp10c, a putative amphipath, represent a novel model of obesity and type 2 diabetes. Dhar, M.S., Sommardahl, C.S., Kirkland, T., Nelson, S., Donnell, R., Johnson, D.K., Castellani, L.W. J. Nutr. (2004) [Pubmed]
  3. An aminophospholipid translocase associated with body fat and type 2 diabetes phenotypes. Dhar, M., Hauser, L., Johnson, D. Obes. Res. (2002) [Pubmed]
  4. Predominant maternal expression of the mouse Atp10c in hippocampus and olfactory bulb. Kashiwagi, A., Meguro, M., Hoshiya, H., Haruta, M., Ishino, F., Shibahara, T., Oshimura, M. J. Hum. Genet. (2003) [Pubmed]
  5. A novel ATPase on mouse chromosome 7 is a candidate gene for increased body fat. Dhar, M., Webb, L.S., Smith, L., Hauser, L., Johnson, D., West, D.B. Physiol. Genomics (2000) [Pubmed]
  6. A type IV P-type ATPase affects insulin-mediated glucose uptake in adipose tissue and skeletal muscle in mice. Dhar, M.S., Yuan, J.S., Elliott, S.B., Sommardahl, C. J. Nutr. Biochem. (2006) [Pubmed]
 
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