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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Inheritance Patterns

 
 
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Disease relevance of Inheritance Patterns

 

Psychiatry related information on Inheritance Patterns

 

High impact information on Inheritance Patterns

 

Chemical compound and disease context of Inheritance Patterns

 

Biological context of Inheritance Patterns

 

Anatomical context of Inheritance Patterns

 

Associations of Inheritance Patterns with chemical compounds

  • Subsequently, mutations in the GLRA1 gene, encoding the alpha1 subunit of the glycine receptor, were found in hyperekplexia families with an autosomal dominant or recessive inheritance pattern [24].
  • The observed reduction in Vmax values for the parents supports an autosomal recessive inheritance pattern and may be a more sensitive indicator of heterozygosity than serum carnitine concentrations.(ABSTRACT TRUNCATED AT 250 WORDS)[25]
  • Specifically, inheritance patterns derived from C3H/HeJ (C3) and C57BL/6J (B6) parental strains suggest that differences in hypoxic ventilatory response (HVR) are controlled by as few as two genes [26].
  • Levels of dopamine in the dorsal and middle caudate-putamen varied according to a simple inheritance pattern, being high in males from AS, F1 and F1 x AS/AGU back crosses without locomotor impairment, but lower in AS/AGU and F1 x AS/AGU back crosses with disordered gait [27].
  • Current research on thyroxine has primarily examined its adaptive potential and genetic inheritance patterns [28].
 

Gene context of Inheritance Patterns

  • These data provide insight into the possible disease mechanisms underlying EGR2 mutations and the reason for varying severity and differences in inheritance patterns [29].
  • Aprt homozygous deficient animals were viable though the mendelian inheritance pattern was skewed [30].
  • One-half of the unrelated subjects were either homozygous or heterozygous for the mutant NAT1 alleles, both of which obeyed a Mendelian inheritance pattern [31].
  • A biallelic polymorphism was found in the second intron of the SOX9 gene and analysis of this marker in the Ellobius family revealed an inheritance pattern completely independent of the sex of the animals [32].
  • In cases where the inheritance pattern is unclear and in sporadic cases the epsilon4 allele of the apolipoprotein E gene (APOE) has been identified as a major risk factor contributing to the pathogenesis of AD in about 20% of the cases [33].

References

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  22. Inheritance of acetohexamide reductase activities in liver microsomes and cytosol of rats. Imamura, Y., Takada, H., Kimura, R., Mori, Y., Otagiri, M. Life Sci. (1996) [Pubmed]
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  25. Impaired skin fibroblast carnitine uptake in primary systemic carnitine deficiency manifested by childhood carnitine-responsive cardiomyopathy. Tein, I., De Vivo, D.C., Bierman, F., Pulver, P., De Meirleir, L.J., Cvitanovic-Sojat, L., Pagon, R.A., Bertini, E., Dionisi-Vici, C., Servidei, S. Pediatr. Res. (1990) [Pubmed]
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