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Gene Review

Cldn11  -  claudin 11

Mus musculus

Synonyms: Claudin-11, Claudin11, Oligodendrocyte transmembrane protein, Oligodendrocyte-specific protein, Osp, ...
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Disease relevance of Cldn11

  • Elucidating the molecular mechanisms underlying TNF-alpha regulation of MBP gene expression provides new scientific bases for the development of therapy against oligodendrocyte-specific and myelin-related disorders such as multiple sclerosis [1].
  • The outer surface protein (Osp) A of Borrelia burgdorferi is the first Lyme antigen to be tested in a vaccine for humans [2].
  • We have generated transgenic mice expressing the entire HIV-1 genome under the regulation of an oligodendrocyte-specific promoter [3].
  • Spirochetes expressing Osp A could also be detected within the first 2 wk of infection, but not at 30 d [4].
  • The murine immune response to Borrelia burgdorferi (Bb), the etiologic agent of Lyme disease, is characterized by the development of antibodies reactive with the outer surface protein (Osp) A [5].

High impact information on Cldn11


Biological context of Cldn11


Anatomical context of Cldn11

  • Indeed, using a model of purified cultured mouse Sertoli cells, we demonstrate that FSH inhibits, in a dose (ED50 = 4 ng/ml)- and time (maximal effect after 24 h)-dependent manner, the levels of OSP mRNA [8].
  • Developmental and hormonal regulation of the expression of oligodendrocyte-specific protein/claudin 11 in mouse testis [8].
  • Our data show that the testicular expression of OSP is dependent upon male gonad development and systemic and local signaling molecules [8].
  • In the prepubertal and adult testes, an apparent decline in OSP messenger RNA (mRNA) levels was found, probably because of the increasing number of germ cells (which do not express OSP) [8].
  • An OSP-specific polyclonal antibody reacted with a single 22-kd protein present in CNS myelin and oligodendrocytes [13].

Associations of Cldn11 with chemical compounds


Regulatory relationships of Cldn11


Other interactions of Cldn11


Analytical, diagnostic and therapeutic context of Cldn11

  • In situ hybridization revealed expression of this cDNA in oligodendrocytes of brain and spinal cord as well as in oligodendrocyte-enriched cultures; therefore we have named it oligodendrocyte-specific protein (OSP) cDNA [13].
  • In testis, well-developed TJ strands of Sertoli cells were specifically labeled with anti-claudin-11/OSP pAb both at immunofluorescence and electron microscopic levels [25].
  • By direct fluorescent staining of uncultured spirochetes ex vivo and by PCR amplification of spirochetal mRNA, we show that Osp C is indeed expressed by some spirochetes after infection in the mouse [4].
  • Osp A mRNA, although present at day 14 of infection, could not be amplified by RT-PCR at day 30, suggesting that the expression of this Osp is transient [4].
  • As expected, vaccination with full-length recombinant Osp A protected mice from challenge infection [5].


  1. Tumor necrosis factor modulates transcription of myelin basic protein gene through nuclear factor kappa B in a human oligodendroglioma cell line. Huang, C.J., Nazarian, R., Lee, J., Zhao, P.M., Espinosa-Jeffrey, A., de Vellis, J. Int. J. Dev. Neurosci. (2002) [Pubmed]
  2. Activation of monocytes by three OspA vaccine candidates: lipoprotein OspA is a potent stimulator of monokines. Häupl, T., Landgraf, S., Netusil, P., Biller, N., Capiau, C., Desmons, P., Hauser, P., Burmester, G.R. FEMS Immunol. Med. Microbiol. (1997) [Pubmed]
  3. Vacuolar myelopathy in transgenic mice expressing human immunodeficiency virus type 1 proteins under the regulation of the myelin basic protein gene promoter. Goudreau, G., Carpenter, S., Beaulieu, N., Jolicoeur, P. Nat. Med. (1996) [Pubmed]
  4. Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease. Montgomery, R.R., Malawista, S.E., Feen, K.J., Bockenstedt, L.K. J. Exp. Med. (1996) [Pubmed]
  5. Inability of truncated recombinant Osp A proteins to elicit protective immunity to Borrelia burgdorferi in mice. Bockenstedt, L.K., Fikrig, E., Barthold, S.W., Kantor, F.S., Flavell, R.A. J. Immunol. (1993) [Pubmed]
  6. CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice. Gow, A., Southwood, C.M., Li, J.S., Pariali, M., Riordan, G.P., Brodie, S.E., Danias, J., Bronstein, J.M., Kachar, B., Lazzarini, R.A. Cell (1999) [Pubmed]
  7. Primary demyelination in transgenic mice expressing interferon-gamma. Horwitz, M.S., Evans, C.F., McGavern, D.B., Rodriguez, M., Oldstone, M.B. Nat. Med. (1997) [Pubmed]
  8. Developmental and hormonal regulation of the expression of oligodendrocyte-specific protein/claudin 11 in mouse testis. Hellani, A., Ji, J., Mauduit, C., Deschildre, C., Tabone, E., Benahmed, M. Endocrinology (2000) [Pubmed]
  9. Disrupted compaction of CNS myelin in an OSP/Claudin-11 and PLP/DM20 double knockout mouse. Chow, E., Mottahedeh, J., Prins, M., Ridder, W., Nusinowitz, S., Bronstein, J.M. Mol. Cell. Neurosci. (2005) [Pubmed]
  10. An oligodendrocyte-specific zinc-finger transcription regulator cooperates with Olig2 to promote oligodendrocyte differentiation. Wang, S.Z., Dulin, J., Wu, H., Hurlock, E., Lee, S.E., Jansson, K., Lu, Q.R. Development (2006) [Pubmed]
  11. Chromosomal localization of murine and human oligodendrocyte-specific protein genes. Bronstein, J.M., Kozak, C.A., Chen, X.N., Wu, S., Danciger, M., Korenberg, J.R., Farber, D.B. Genomics (1996) [Pubmed]
  12. Myelin basic protein functions as a microtubule stabilizing protein in differentiated oligodendrocytes. Galiano, M.R., Andrieux, A., Deloulme, J.C., Bosc, C., Schweitzer, A., Job, D., Hallak, M.E. J. Neurosci. Res. (2006) [Pubmed]
  13. Isolation and characterization of a novel oligodendrocyte-specific protein. Bronstein, J.M., Popper, P., Micevych, P.E., Farber, D.B. Neurology (1996) [Pubmed]
  14. Oligodendrocyte-specific ceramide galactosyltransferase (CGT) expression phenotypically rescues CGT-deficient mice and demonstrates that CGT activity does not limit brain galactosylceramide level. Zöller, I., Büssow, H., Gieselmann, V., Eckhardt, M. Glia (2005) [Pubmed]
  15. Molecular cloning and functional characterization of the receptor for Clostridium perfringens enterotoxin. Katahira, J., Inoue, N., Horiguchi, Y., Matsuda, M., Sugimoto, N. J. Cell Biol. (1997) [Pubmed]
  16. Antibodies to myelin/oligodendrocyte-specific protein and myelin/oligodendrocyte glycoprotein signal distinct changes in the organization of cultured oligodendroglial membrane sheets. Dyer, C.A., Matthieu, J.M. J. Neurochem. (1994) [Pubmed]
  17. A population of oligodendrocytes derived from multipotent neural precursor cells expresses a cholinergic phenotype in culture and responds to ciliary neurotrophic factor. MacDonald, S.C., Simcoff, R., Jordan, L.M., Dodd, J.G., Cheng, K.W., Hochman, S. J. Neurosci. Res. (2002) [Pubmed]
  18. A 14,000 MW lipoprotein and a glycolipid-like structure of Borrelia burgdorferi induce proliferation and immunoglobulin production in mouse B cells at high frequencies. Honarvar, N., Schaible, U.E., Galanos, C., Wallich, R., Simon, M.M. Immunology (1994) [Pubmed]
  19. Rumpshaker-like proteolipid protein (PLP) ratio in a mouse model with unperturbed structural and functional integrity of the myelin sheath and axons in the central nervous system. Uschkureit, T., Spörkel, O., Büssow, H., Stoffel, W. Glia (2001) [Pubmed]
  20. Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination. Emery, B., Cate, H.S., Marriott, M., Merson, T., Binder, M.D., Snell, C., Soo, P.Y., Murray, S., Croker, B., Zhang, J.G., Alexander, W.S., Cooper, H., Butzkueven, H., Kilpatrick, T.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  21. Truncated prion protein and Doppel are myelinotoxic in the absence of oligodendrocytic PrPC. Radovanovic, I., Braun, N., Giger, O.T., Mertz, K., Miele, G., Prinz, M., Navarro, B., Aguzzi, A. J. Neurosci. (2005) [Pubmed]
  22. Transgenic systems in studying myelin gene expression. Ikenaka, K., Kagawa, T. Dev. Neurosci. (1995) [Pubmed]
  23. Expression patterns of claudins, tight junction adhesion molecules, in the inner ear. Kitajiri, S.I., Furuse, M., Morita, K., Saishin-Kiuchi, Y., Kido, H., Ito, J., Tsukita, S. Hear. Res. (2004) [Pubmed]
  24. Orientation of the myelin proteolipid protein C-terminus in oligodendroglial membranes. Konola, J.T., Yamamura, T., Tyler, B., Lees, M.B. Glia (1992) [Pubmed]
  25. Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis. Morita, K., Sasaki, H., Fujimoto, K., Furuse, M., Tsukita, S. J. Cell Biol. (1999) [Pubmed]
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