Disease relevance of TBN

• Among secondary GNs, systemic lupus erythematosus (SLE) represented 23.0%, necrotizing vasculitis (NV) 15.5%, Henoch-Schonlein purpura 5.7%, thin basement membrane glomerulopathy (TBN) 19.3%, Alport syndrome 6.9%, renal amyloidosis 9.9% and myeloma kidney 2.9% [1].

High impact information on TBN

• The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis [2].
• These data suggest a selective role for TAF8 in a specific cell differentiation process(es) [2].
• Significantly, we also show that TAF8 is dramatically induced and sequestered within TFIID upon differentiation of 3T3-L1 preadipocytes to adipocytes, whereas the expression of all other TAFs tested is slightly reduced [2].
• Of interest, PTX, adenosine, DBcAMP, and TBN have different effects depending upon functional assay and activating agent [3].
• Recent evidence, however, suggests that DF32P underestimates, and 51Cr overestimates, the blood neutrophil T1/2 and that both isotopes overestimate the TBNP, compared with 3H-TdR-derived data [4].

Biological context of TBN

• The four-compartment model of body composition was examined in 155 white women through measurement of total body carbon (TBC), nitrogen (TBN), calcium (TBCa), and water levels [5].
• A systems study is proposed to explore correctly the effects of the combination of HDT (Head Down Tilt) and TBNP (Total Body Negative Pressure) [6].

Other interactions of TBN

• Subcloning experiments have demonstrated that all the information required for the generation and high level accumulation of the TBN transcripts is encoded in the 1.6 kb DHFR DNA minigene [7].
• 3. A continued partnership between the university, the school of nursing, the TNF, the TBN, and the various health care providers and nurse practitioners is needed to address the problem of chemical dependency in nursing [8].

Analytical, diagnostic and therapeutic context of TBN

• When adjusted for body size, the deficit of TBN in the cancer patients was approximately half that observed for TBK [9].
• RNA blotting, RNase mapping, primer extension, RT-PCR, and sequencing have shown that this highly expressed transcript, termed TBN, is a spliced RNA product which utilizes cryptic splice signals present in the normally spliced DHFR mRNA [7].

References