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MeSH Review

Head-Down Tilt

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Disease relevance of Head-Down Tilt


High impact information on Head-Down Tilt


Chemical compound and disease context of Head-Down Tilt


Biological context of Head-Down Tilt


Anatomical context of Head-Down Tilt


Associations of Head-Down Tilt with chemical compounds

  • With the needle left in place and the patient in the Trendelenburg position, the contrast agent is sequentially displaced above any encountered extradural blocks by further injection of diluent or sterile saline into the caudal thecal sac [23].
  • Materials and Methods: Plasma epinephrine and norepinephrine were evaluated in 29 patients who underwent laparoscopic retroperitoneal surgery in a half lateral decubitus position (group 1) or laparoscopic varicocelectomy in a Trendelenburg position (group 2) [24].
  • We studied healthy humans under three separate conditions: control, acute 10 degrees head-down tilt (HDT), and saline infusion (SAL) [25].
  • After 1 and 2 weeks of suspension in an antiorthostatic (head-down tilt) position, the mice were challenged with polyriboinosinic-polyribocytidylic acid to induce interferon-alpha/beta [26].
  • We measured renal functions and hormones associated with fluid regulation after a bolus injection of aldosterone (Ald) during head-down tilt (HDT) bed rest to test the hypothesis that exposure to simulated microgravity altered renal responsiveness to Ald [27].

Gene context of Head-Down Tilt

  • Effects of head-down tilt on atrial natriuretic peptide and the renin system in pregnancy [28].
  • Modifications of plasma levels of tissue factor pathway inhibitor and endothelin-1 induced by a reverse Trendelenburg position: influence of elastic compression--preliminary results [29].
  • Twenty-four men (31 +/- 3 yr) underwent 5 d of 6 degree head-down tilt: eight performed no exercise (CON), eight performed upright treadmill exercise (UPex), and eight performed supine treadmill exercise against LBNP at -51.3 +/- 0.4 mm Hg (LBNPex) [30].
  • A head-down tilt on the other side induces central engorgement leading to a decrease of EPO concentrations [31].
  • Alternative experimental models conducted to simulate the effects of weightlessness in humans such as head-down tilt (HDT) and lower body positive pressure (LBPP) have yielded less consistent results than those of water immersion (WI) with respect to renal function [32].

Analytical, diagnostic and therapeutic context of Head-Down Tilt


  1. Acute effects of head-down tilt and hypoxia on modulators of fluid homeostasis. Whitson, P.A., Cintron, N.M., Pietrzyk, R.A., Scotto, P., Loeppky, J.A. Journal of clinical pharmacology. (1994) [Pubmed]
  2. Impaired suppression of plasma norepinephrine during head-down tilt in patients with congestive heart failure. Goldsmith, S.R. Am. Heart J. (1991) [Pubmed]
  3. Hemodynamic changes during laparoscopic cholecystectomy monitored with transesophageal echocardiography. Dorsay, D.A., Greene, F.L., Baysinger, C.L. Surgical endoscopy. (1995) [Pubmed]
  4. Studies of anaesthesia in relation to hypertension. VI: Cardiovascular responses to extradural blockade of treated and untreated hypertensive patients. Dagnino, J., Prys-Roberts, C. British journal of anaesthesia. (1984) [Pubmed]
  5. Plasma atrial natriuretic peptide: concentrations and circulating forms in normal man and patients with chronic renal failure. Ogawa, K., Smith, A.I., Hodsman, G.P., Jackson, B., Woodcock, E.A., Johnston, C.I. Clin. Exp. Pharmacol. Physiol. (1987) [Pubmed]
  6. The hypotensive effect of intravenous streptokinase in patients with acute myocardial infarction. Lew, A.S., Laramee, P., Cercek, B., Shah, P.K., Ganz, W. Circulation (1985) [Pubmed]
  7. Effect of a pressor infusion of angiotensin II on sympathetic activity and heart rate in normal humans. Goldsmith, S.R., Hasking, G.J. Circ. Res. (1991) [Pubmed]
  8. Intravenous pamidronate prevents femoral bone loss and renal stone formation during 90-day bed rest. Watanabe, Y., Ohshima, H., Mizuno, K., Sekiguchi, C., Fukunaga, M., Kohri, K., Rittweger, J., Felsenberg, D., Matsumoto, T., Nakamura, T. J. Bone Miner. Res. (2004) [Pubmed]
  9. Effect of digitalis on norepinephrine kinetics in congestive heart failure. Goldsmith, S.R., Simon, A.B., Miller, E. J. Am. Coll. Cardiol. (1992) [Pubmed]
  10. Baroreflex loading maneuvers do not suppress increased plasma arginine vasopressin in patients with congestive heart failure. Goldsmith, S.R. J. Am. Coll. Cardiol. (1992) [Pubmed]
  11. Cardiopulmonary responses to acute hypoxia, head-down tilt and fluid loading in anesthetized dogs. Loeppky, J.A., Scotto, P., Riedel, C., Avasthi, P., Koshukosky, V., Chick, T.W. Aviation, space, and environmental medicine. (1991) [Pubmed]
  12. Rabbit model of cardiopulmonary bypass. Kim, W.G., Moon, H.J., Won, T.H., Chee, H.K. Perfusion (1999) [Pubmed]
  13. A comparison of head-down tilt with low-dose infusion of atrial natriuretic peptide in man. Allen, M.J., Ang, V.T., Bennett, D. J. Physiol. (Lond.) (1989) [Pubmed]
  14. Effect of the head-down tilt position during lower abdominal surgery on endocrine and renal function response. Hirose, M., Hashimoto, S., Tanaka, Y. Anesth. Analg. (1993) [Pubmed]
  15. Changes in microvascular fluid filtration capacity during 120 days of 6 degrees head-down tilt. Christ, F., Gamble, J., Baranov, V., Kotov, A., Chouker, A., Thiel, M., Gartside, I.B., Moser, C.M., Abicht, J., Messmer, K. J. Appl. Physiol. (2001) [Pubmed]
  16. Baroreceptor-mediated suppression of osmotically stimulated vasopressin in normal humans. Goldsmith, S.R. J. Appl. Physiol. (1988) [Pubmed]
  17. Relation between cycle length, volume, and pressure in type I atrial flutter. Vulliemin, P., Del Bufalo, A., Schlaepfer, J., Fromer, M., Kappenberger, L. Pacing and clinical electrophysiology : PACE. (1994) [Pubmed]
  18. Is chronic tension-type headache a vascular headache? The relation between chronic tension-type headache and cranial hemodynamics. Hannerz, J., Jogestrand, T. Headache. (1998) [Pubmed]
  19. Fractal analysis of cytoskeleton rearrangement in cardiac muscle during head-down tilt. Thomason, D.B., Anderson, O., Menon, V. J. Appl. Physiol. (1996) [Pubmed]
  20. Benign paroxysmal positional vertigo can interfere with the cardiac response to head-down tilt. Jáuregui-Renaud, K., Aw, S.T., Todd, M.J., McGarvie, L.A., Halmagyi, G.M. Otol. Neurotol. (2005) [Pubmed]
  21. A comparison of the effects of lower body positive pressure and head-down tilt on cardiovascular responses in humans. Fu, Q., Sugiyama, Y., Kamiya, A., Iwase, S., Mano, T. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology. (1999) [Pubmed]
  22. Herniation secondary to critical postcraniotomy cerebrospinal fluid hypovolemia. Komotar, R.J., Mocco, J., Ransom, E.R., Mack, W.J., Zacharia, B.E., Wilson, D.A., Naidech, A.M., McKhann, G.M., Mayer, S.A., Fitzsimmons, B.F., Connolly, E.S. Neurosurgery (2005) [Pubmed]
  23. Epidural block: myelographic evaluation with a single-puncture technique using metrizamide. Kelly, W.M., Badami, P., Dillon, W. Radiology. (1984) [Pubmed]
  24. Catecholamine release caused by carbon dioxide insufflation during laparoscopic surgery. Mikami, O., Kawakita, S., Fujise, K., Shingu, K., Takahashi, H., Matsuda, T. J. Urol. (1996) [Pubmed]
  25. Influence of increased central venous pressure on baroreflex control of sympathetic activity in humans. Charkoudian, N., Martin, E.A., Dinenno, F.A., Eisenach, J.H., Dietz, N.M., Joyner, M.J. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  26. Effect of antiorthostatic suspension on interferon-alpha/beta production by the mouse. Rose, A., Steffen, J.M., Musacchia, X.J., Mandel, A.D., Sonnenfeld, G. Proc. Soc. Exp. Biol. Med. (1984) [Pubmed]
  27. Renal responsiveness to aldosterone during exposure to simulated microgravity. Convertino, V.A., Luetkemeier, M.J., Elliott, J.J., Ludwig, D.A., Wade, C.E. J. Appl. Physiol. (2000) [Pubmed]
  28. Effects of head-down tilt on atrial natriuretic peptide and the renin system in pregnancy. Poulsen, H., Olofsson, P., Stjernquist, M. Hypertension (1995) [Pubmed]
  29. Modifications of plasma levels of tissue factor pathway inhibitor and endothelin-1 induced by a reverse Trendelenburg position: influence of elastic compression--preliminary results. Arcelus, J.I., Caprini, J.A., Hoffman, K.N., Traverso, C.I., Hoppensteadt, D., Fareed, J. J. Vasc. Surg. (1995) [Pubmed]
  30. Upright exercise or supine lower body negative pressure exercise maintains exercise responses after bed rest. Lee, S.M., Bennett, B.S., Hargens, A.R., Watenpaugh, D.E., Ballard, R.E., Murthy, G., Ford, S.R., Fortney, S.M. Medicine and science in sports and exercise. (1997) [Pubmed]
  31. Erythropoietin as a volume-regulating hormone: an integrated view. Kirsch, K.A., Schlemmer, M., De Santo, N.G., Cirillo, M., Perna, A., Gunga, H.C. Semin. Nephrol. (2005) [Pubmed]
  32. Gravitational stress and volume regulation. Norsk, P. Clinical physiology (Oxford, England) (1992) [Pubmed]
  33. Relationship between chronic tension-type headache, cranial hemodynamics, and cerebrospinal pressure: study involving provocation with sumatriptan. Hannerz, J., Jogestrand, T. Headache. (2004) [Pubmed]
  34. Hyperbaric bupivacaine for spinal anesthesia in cesarean section. Santos, A., Pedersen, H., Finster, M., Edström, H. Anesth. Analg. (1984) [Pubmed]
  35. Head down tilt at -6 degrees to -24 degrees can neutralize the cardiovascular effects of LBNP at -15 or -35 mmHg. Hinghofer-Szalkay, H., Haditsch, B., Loder, I., Pilz, K., Rössler, A., Jezova, D. Aviation, space, and environmental medicine. (2004) [Pubmed]
  36. The effects of 10 degrees reverse trendelenburg position on ICP and CPP in prone positioned patients subjected to craniotomy for occipital or cerebellar tumours. Tankisi, A., Rolighed Larsen, J., Rasmussen, M., Dahl, B., Cold, G.E. Acta neurochirurgica. (2002) [Pubmed]
  37. Underestimation of plasma volume changes in humans by hematocrit/hemoglobin method. Johansen, L.B., Videbaek, R., Hammerum, M., Norsk, P. Am. J. Physiol. (1998) [Pubmed]
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