Gene Review:
Cdkn2a - cyclin-dependent kinase inhibitor 2A
Mus musculus
Synonyms:
ARF-INK4a, Arf, CDK4I, Cyclin-dependent kinase 4 inhibitor A, Cyclin-dependent kinase inhibitor 2A, isoform 3, ...
- Pathways to melanoma development: lessons from the mouse. Walker, G.J., Hayward, N.K. J. Invest. Dermatol. (2002)
- Cdkn2a encodes functional variation of p16INK4a but not p19ARF, which confers selection in mouse lung tumorigenesis. Herzog, C.R., Noh, S., Lantry, L.E., Guan, K.L., You, M. Mol. Carcinog. (1999)
- Loss of p16INK4a results in increased glucocorticoid receptor activity during fibrosarcoma development. Roca, R., Kypta, R.M., Vivanco, M.M. Proc. Natl. Acad. Sci. U.S.A. (2003)
- p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation. Radfar, A., Unnikrishnan, I., Lee, H.W., DePinho, R.A., Rosenberg, N. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Loss of xeroderma pigmentosum C (Xpc) enhances melanoma photocarcinogenesis in Ink4a-Arf-deficient mice. Yang, G., Curley, D., Bosenberg, M.W., Tsao, H. Cancer Res. (2007)
- Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19Arf/p53 pathway lesions but not p16 Ink4a loss. Debies, M.T., Gestl, S.A., Mathers, J.L., Mikse, O.R., Leonard, T.L., Moody, S.E., Chodosh, L.A., Cardiff, R.D., Gunther, E.J. J. Clin. Invest. (2008)
- Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility. Zhang, S.L., DuBois, W., Ramsay, E.S., Bliskovski, V., Morse, H.C., Taddesse-Heath, L., Vass, W.C., DePinho, R.A., Mock, B.A. Mol. Cell. Biol. (2001)
- Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Bulavin, D.V., Phillips, C., Nannenga, B., Timofeev, O., Donehower, L.A., Anderson, C.W., Appella, E., Fornace, A.J. Nat. Genet. (2004)
- A role for the Rb family of proteins in controlling telomere length. García-Cao, M., Gonzalo, S., Dean, D., Blasco, M.A. Nat. Genet. (2002)
- A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Schmitt, C.A., Fridman, J.S., Yang, M., Lee, S., Baranov, E., Hoffman, R.M., Lowe, S.W. Cell (2002)
- Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice. Lund, A.H., Turner, G., Trubetskoy, A., Verhoeven, E., Wientjens, E., Hulsman, D., Russell, R., DePinho, R.A., Lenz, J., van Lohuizen, M. Nat. Genet. (2002)
- Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16. Rossi, F.M., Guicherit, O.M., Spicher, A., Kringstein, A.M., Fatyol, K., Blakely, B.T., Blau, H.M. Nat. Genet. (1998)
- Inactivations of p16INK4a-alpha, p16INK4a-beta and p15INK4b genes in 2',3'-dideoxycytidine- and 1,3-butadiene-induced murine lymphomas. Zhuang, S.M., Schippert, A., Haugen-Strano, A., Wiseman, R.W., Söderkvist, P. Oncogene (1998)
- p27 deficiency desensitizes Rb-/- cells to signals that trigger apoptosis during pituitary tumor development. Carneiro, C., Jiao, M.S., Hu, M., Shaffer, D., Park, M., Pandolfi, P.P., Cordon-Cardo, C., Koff, A. Oncogene (2003)
- Combination of gemcitabine and Ad5/3-Delta24, a tropism modified conditionally replicating adenovirus, for the treatment of ovarian cancer. Raki, M., Kanerva, A., Ristimaki, A., Desmond, R.A., Chen, D.T., Ranki, T., Sarkioja, M., Kangasniemi, L., Hemminki, A. Gene Ther. (2005)
- Melanocyte development and malignant melanoma. Goding, C.R. Forum (Genoa, Italy) (2000)
- Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes. Isono, K., Fujimura, Y., Shinga, J., Yamaki, M., O-Wang, J., Takihara, Y., Murahashi, Y., Takada, Y., Mizutani-Koseki, Y., Koseki, H. Mol. Cell. Biol. (2005)
- BALB/c alleles for Prkdc and Cdkn2a interact to modify tumor susceptibility in Trp53+/- mice. Blackburn, A.C., Brown, J.S., Naber, S.P., Otis, C.N., Wood, J.T., Jerry, D.J. Cancer Res. (2003)
- Deregulated c-Myb expression in murine myeloid leukemias prevents the up-regulation of p15(INK4b) normally associated with differentiation. Schmidt, M., Koller, R., Haviernik, P., Bies, J., Maciag, K., Wolff, L. Oncogene (2001)
- Pattern of secondary genomic changes in pancreatic tumors of Tgf alpha/Trp53+/- transgenic mice. Schreiner, B., Baur, D.M., Fingerle, A.A., Zechner, U., Greten, F.R., Adler, G., Sipos, B., Klöppel, G., Hameister, H., Schmid, R.M. Genes Chromosomes Cancer (2003)
- Role of tumor suppressor genes in transplacental lung carcinogenesis. Rollins, L.A., Leone-Kabler, S., O'Sullivan, M.G., Miller, M.S. Mol. Carcinog. (1998)
- Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Sharpless, N.E., Bardeesy, N., Lee, K.H., Carrasco, D., Castrillon, D.H., Aguirre, A.J., Wu, E.A., Horner, J.W., DePinho, R.A. Nature (2001)
- Homozygous codeletion and differential decreased expression of p15INK4b, p16INK4a-alpha and p16INK4a-beta in mouse lung tumor cells. Herzog, C.R., Soloff, E.V., McDoniels, A.L., Tyson, F.L., Malkinson, A.M., Haugen-Strano, A., Wiseman, R.W., Anderson, M.W., You, M. Oncogene (1996)
- p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB. Zhang, S., Qian, X., Redman, C., Bliskovski, V., Ramsay, E.S., Lowy, D.R., Mock, B.A. Oncogene (2003)
- Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland. Foster, C.J., Lozano, G. Oncogene (2002)
- The absence of p53 is critical for the induction of apoptosis by 5-aza-2'-deoxycytidine. Nieto, M., Samper, E., Fraga, M.F., González de Buitrago, G., Esteller, M., Serrano, M. Oncogene (2004)
- Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf. Zhang, Z., Wang, Y., Lantry, L.E., Kastens, E., Liu, G., Hamilton, A.D., Sebti, S.M., Lubet, R.A., You, M. Oncogene (2003)
- Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages. Randle, D.H., Zindy, F., Sherr, C.J., Roussel, M.F. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion. Khan, S.H., Moritsugu, J., Wahl, G.M. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics. Aslanian, A., Iaquinta, P.J., Verona, R., Lees, J.A. Genes Dev. (2004)
- Cdk6-cyclin D3 activity in murine ES cells is resistant to inhibition by p16(INK4a). Faast, R., White, J., Cartwright, P., Crocker, L., Sarcevic, B., Dalton, S. Oncogene (2004)
- JunB suppresses cell proliferation by transcriptional activation of p16(INK4a) expression. Passegué, E., Wagner, E.F. EMBO J. (2000)
- Hepatitis B virus X protein increases expression of p21(Cip-1/WAF1/MDA6) and p27(Kip-1) in primary mouse hepatocytes, leading to reduced cell cycle progression. Qiao, L., Leach, K., McKinstry, R., Gilfor, D., Yacoub, A., Park, J.S., Grant, S., Hylemon, P.B., Fisher, P.B., Dent, P. Hepatology (2001)
- A BAR domain in the N terminus of the Arf GAP ASAP1 affects membrane structure and trafficking of epidermal growth factor receptor. Nie, Z., Hirsch, D.S., Luo, R., Jian, X., Stauffer, S., Cremesti, A., Andrade, J., Lebowitz, J., Marino, M., Ahvazi, B., Hinshaw, J.E., Randazzo, P.A. Curr. Biol. (2006)
- Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function. Kamijo, T., van de Kamp, E., Chong, M.J., Zindy, F., Diehl, J.A., Sherr, C.J., McKinnon, P.J. Cancer Res. (1999)
- Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. Bruggeman, S.W., Valk-Lingbeek, M.E., van der Stoop, P.P., Jacobs, J.J., Kieboom, K., Tanger, E., Hulsman, D., Leung, C., Arsenijevic, Y., Marino, S., van Lohuizen, M. Genes Dev. (2005)
- Cyclin D1 is an essential mediator of apoptotic neuronal cell death. Kranenburg, O., van der Eb, A.J., Zantema, A. EMBO J. (1996)
- Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins. Alevizopoulos, K., Vlach, J., Hennecke, S., Amati, B. EMBO J. (1997)
- Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models. Zhang, Z., Wang, Y., Yao, R., Li, J., Yan, Y., La Regina, M., Lemon, W.L., Grubbs, C.J., Lubet, R.A., You, M. Oncogene (2004)
- Overexpression of p21 protein in radiation-transformed mouse 10T(1/2) cell clones. Krolewski, B., Little, J.B. Mol. Carcinog. (2000)
- Homozygous deletion of mouse homolog of p16/CDKN2 gene on chromosome 4 in mouse liver epithelial cells in culture. Miyasaka, K., Kawauchi, S. Biol. Pharm. Bull. (1996)
- Ink4a/Arf expression is a biomarker of aging. Krishnamurthy, J., Torrice, C., Ramsey, M.R., Kovalev, G.I., Al-Regaiey, K., Su, L., Sharpless, N.E. J. Clin. Invest. (2004)
- Mice with alterations in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: differential chemopreventive effect of budesonide in wild-type and mutant A/J mice. Wang, Y., Zhang, Z., Kastens, E., Lubet, R.A., You, M. Cancer Res. (2003)