The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

GATA5  -  GATA binding protein 5

Homo sapiens

Synonyms: GATA-binding factor 5, GATAS, Transcription factor GATA-5, bB379O24.1
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of GATA5

 

High impact information on GATA5

  • Expression of exogenous GATA-5 overrides methylation at the downstream promoters to activate the target genes [2].
  • GATA5 activation of the progesterone receptor gene promoter in breast cancer cells is influenced by the +331G/A polymorphism [1].
  • The results indicate that GATA5 is induced at an early stage of endothelial-endocardial differentiation prior to expression of such early endocardial markers as Tie2 and ErbB3 [5].
  • Physical interaction between GATA-5 and hepatocyte nuclear factor-1alpha results in synergistic activation of the human lactase-phlorizin hydrolase promoter [6].
  • RESULTS: Complete methylation was detected by methylation-specific PCR for both GATA-4 and GATA-5 in four cell lines (H358, DMS-53, A549, and H1299), all of which had no expression by reverse transcription-PCR analysis [3].
 

Biological context of GATA5

 

Anatomical context of GATA5

 

Regulatory relationships of GATA5

  • By means of luciferase assay, GATA-5 was found to activate the promoters of the human MUC2 and MUC4 genes [8].
 

Other interactions of GATA5

  • Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1 alpha [10].
  • Normal tissues showed significantly lower frequencies of promoter methylation of APC, p16(INK4A), GATA-4, and GATA-5 (P-values: 0.02, 0.02, 1.1x10(-5) and 0.008 respectively) [11].
 

Analytical, diagnostic and therapeutic context of GATA5

References

  1. GATA5 activation of the progesterone receptor gene promoter in breast cancer cells is influenced by the +331G/A polymorphism. Huggins, G.S., Wong, J.Y., Hankinson, S.E., De Vivo, I. Cancer Res. (2006) [Pubmed]
  2. GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer. Akiyama, Y., Watkins, N., Suzuki, H., Jair, K.W., van Engeland, M., Esteller, M., Sakai, H., Ren, C.Y., Yuasa, Y., Herman, J.G., Baylin, S.B. Mol. Cell. Biol. (2003) [Pubmed]
  3. Hypermethylation of the GATA genes in lung cancer. Guo, M., Akiyama, Y., House, M.G., Hooker, C.M., Heath, E., Gabrielson, E., Yang, S.C., Han, Y., Baylin, S.B., Herman, J.G., Brock, M.V. Clin. Cancer Res. (2004) [Pubmed]
  4. Hypermethylation of the GATA gene family in esophageal cancer. Guo, M., House, M.G., Akiyama, Y., Qi, Y., Capagna, D., Harmon, J., Baylin, S.B., Brock, M.V., Herman, J.G. Int. J. Cancer (2006) [Pubmed]
  5. Cooperative interaction between GATA5 and NF-ATc regulates endothelial-endocardial differentiation of cardiogenic cells. Nemer, G., Nemer, M. Development (2002) [Pubmed]
  6. Physical interaction between GATA-5 and hepatocyte nuclear factor-1alpha results in synergistic activation of the human lactase-phlorizin hydrolase promoter. van Wering, H.M., Huibregtse, I.L., van der Zwan, S.M., de Bie, M.S., Dowling, L.N., Boudreau, F., Rings, E.H., Grand, R.J., Krasinski, S.D. J. Biol. Chem. (2002) [Pubmed]
  7. Cooperative interactions among intestinal GATA factors in activating the rat liver fatty acid binding protein gene. Divine, J.K., Staloch, L.J., Haveri, H., Rowley, C.W., Heikinheimo, M., Simon, T.C. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  8. Transcription factor GATA-5 selectively up-regulates mucin gene expression. Ren, C.Y., Akiyama, Y., Miyake, S., Yuasa, Y. J. Cancer Res. Clin. Oncol. (2004) [Pubmed]
  9. Distinct expression of CDX2 and GATA4/5, development-related genes, in human gastric cancer cell lines. Bai, Y., Akiyama, Y., Nagasaki, H., Yagi, O.K., Kikuchi, Y., Saito, N., Takeshita, K., Iwai, T., Yuasa, Y. Mol. Carcinog. (2000) [Pubmed]
  10. Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1 alpha. Krasinski, S.D., Van Wering, H.M., Tannemaat, M.R., Grand, R.J. Am. J. Physiol. Gastrointest. Liver Physiol. (2001) [Pubmed]
  11. Promoter methylation precedes chromosomal alterations in colorectal cancer development. Derks, S., Postma, C., Moerkerk, P.T., van den Bosch, S.M., Carvalho, B., Hermsen, M.A., Giaretti, W., Herman, J.G., Weijenberg, M.P., Bru??ne, A.P., Meijer, G.A., van Engeland, M. Cell. Oncol. (2006) [Pubmed]
 
WikiGenes - Universities