Gene Review:
MUC2 - mucin 2, oligomeric mucus/gel-forming
Homo sapiens
Synonyms:
Intestinal mucin-2, MLP, MUC-2, Mucin-2, SMUC
Longman,
Douthwaite,
Sylvester,
Poulsom,
Corfield,
Thomas,
Wright,
Rossi,
Murer,
Cavazza,
Losi,
Natali,
Marchioni,
Migaldi,
Capitanio,
Brambilla,
Paulsen,
Corfield,
Hinz,
Hoffmann,
Schaudig,
Thale,
Berry,
Jang,
Chae,
Sohn,
Park,
Shin,
Ookawa,
Kudo,
Aizawa,
Saito,
Tsuchida,
Boman,
Buisine,
Wacrenier,
Querleu,
Aubert,
Porchet,
Chu,
Schwarz,
Lau,
Yen,
Weiss,
- Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium. Ho, S.B., Shekels, L.L., Toribara, N.W., Kim, Y.S., Lyftogt, C., Cherwitz, D.L., Niehans, G.A. Cancer Res. (1995)
- Heterogeneity of mucin gene expression in normal and neoplastic tissues. Ho, S.B., Niehans, G.A., Lyftogt, C., Yan, P.S., Cherwitz, D.L., Gum, E.T., Dahiya, R., Kim, Y.S. Cancer Res. (1993)
- Differential expression of the chromosome 11 mucin genes in colorectal cancer. Sylvester, P.A., Myerscough, N., Warren, B.F., Carlstedt, I., Corfield, A.P., Durdey, P., Thomas, M.G. J. Pathol. (2001)
- Mucin gene transcripts in benign and borderline mucinous tumours of the ovary: an in situ hybridization study. Boman, F., Buisine, M.P., Wacrenier, A., Querleu, D., Aubert, J.P., Porchet, N. J. Pathol. (2001)
- Second-generation monoclonal antibodies to intestinal MUC2 peptide reactive with colon cancer. Xing, P.X., Prenzoska, J., Layton, G.T., Devine, P.L., McKenzie, I.F. J. Natl. Cancer Inst. (1992)
- Aberrant expression of a human mucin gene (MUC5AC) in rectosigmoid villous adenoma. Buisine, M.P., Janin, A., Maunoury, V., Audié, J.P., Delescaut, M.P., Copin, M.C., Colombel, J.F., Degand, P., Aubert, J.P., Porchet, N. Gastroenterology (1996)
- Altered expression of MUC2, MUC4, and MUC5 mucin genes in pancreas tissues and cancer cell lines. Balagué, C., Gambús, G., Carrato, C., Porchet, N., Aubert, J.P., Kim, Y.S., Real, F.X. Gastroenterology (1994)
- MUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas: their roles as prognostic indicators. Lee, H.S., Lee, H.K., Kim, H.S., Yang, H.K., Kim, Y.I., Kim, W.H. Cancer (2001)
- Partial D-amino acid substitution: Improved enzymatic stability and preserved Ab recognition of a MUC2 epitope peptide. Tugyi, R., Uray, K., Iván, D., Fellinger, E., Perkins, A., Hudecz, F. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Pseudomyxoma peritonei is a disease of MUC2-expressing goblet cells. O'Connell, J.T., Tomlinson, J.S., Roberts, A.A., McGonigle, K.F., Barsky, S.H. Am. J. Pathol. (2002)
- Transcriptional activation of the MUC2 gene by p53. Ookawa, K., Kudo, T., Aizawa, S., Saito, H., Tsuchida, S. J. Biol. Chem. (2002)
- Low O-acetylation of sialyl-Le(x) contributes to its overexpression in colon carcinoma metastases. Mann, B., Klussmann, E., Vandamme-Feldhaus, V., Iwersen, M., Hanski, M.L., Riecken, E.O., Buhr, H.J., Schauer, R., Kim, Y.S., Hanski, C. Int. J. Cancer (1997)
- Role of fucosyltransferases in the association between apomucin and Lewis antigen expression in normal and malignant gastric epithelium. López-Ferrer, A., de Bolós, C., Barranco, C., Garrido, M., Isern, J., Carlstedt, I., Reis, C.A., Torrado, J., Real, F.X. Gut (2000)
- The human MUC2 mucin apoprotein appears to dimerize before O-glycosylation and shares epitopes with the 'insoluble' mucin of rat small intestine. Asker, N., Baeckström, D., Axelsson, M.A., Carlstedt, I., Hansson, G.C. Biochem. J. (1995)
- Human mucin gene MUC5AC: organization of its 5'-region and central repetitive region. Escande, F., Aubert, J.P., Porchet, N., Buisine, M.P. Biochem. J. (2001)
- Mucin gene expression in human urothelium and in intestinal segments transposed into the urinary tract. N'Dow, J., Pearson, J.P., Bennett, M.K., Neal, D.E., Robson, C.N. J. Urol. (2000)
- Differential mucin MUC7 gene expression in invasive bladder carcinoma in contrast to uniform MUC1 and MUC2 gene expression in both normal urothelium and bladder carcinoma. Retz, M., Lehmann, J., Röder, C., Plötz, B., Harder, J., Eggers, J., Pauluschke, J., Kalthoff, H., Stöckle, M. Cancer Res. (1998)
- Expression of apomucins in the intrahepatic biliary tree in hepatolithiasis differs from that in normal liver and extrahepatic biliary obstruction. Sasaki, M., Nakanuma, Y., Kim, Y.S. Hepatology (1998)
- Genomic organization of the 3' region of the human mucin gene MUC5B. Desseyn, J.L., Aubert, J.P., Van Seuningen, I., Porchet, N., Laine, A. J. Biol. Chem. (1997)
- Evolutionary history of the 11p15 human mucin gene family. Desseyn, J.L., Buisine, M.P., Porchet, N., Aubert, J.P., Degand, P., Laine, A. J. Mol. Evol. (1998)
- Vasoactive intestinal peptide upregulates MUC2 intestinal mucin via CREB/ATF1. Hokari, R., Lee, H., Crawley, S.C., Yang, S.C., Gum, J.R., Miura, S., Kim, Y.S. Am. J. Physiol. Gastrointest. Liver Physiol. (2005)
- Expression of human TFF3 in relation to growth of HT-29 cell subpopulations: involvement of PI3-K but not STAT6. Durual, S., Blanchard, C., Estienne, M., Jacquier, M.F., Cuber, J.C., Perrot, V., Laboisse, C., Cuber, J.C. Differentiation (2005)
- Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B. Lee, H.W., Ahn, D.H., Crawley, S.C., Li, J.D., Gum, J.R., Basbaum, C.B., Fan, N.Q., Szymkowski, D.E., Han, S.Y., Lee, B.H., Sleisenger, M.H., Kim, Y.S. J. Biol. Chem. (2002)
- Coexpression of MUC1 with p53 or MUC2 correlates with lymph node metastasis in colorectal carcinomas. Jang, K.T., Chae, S.W., Sohn, J.H., Park, H.R., Shin, H.S. J. Korean Med. Sci. (2002)
- Expression of MUC1, MUC2, MUC3 and MUC4 mucin mRNAs in human pancreatic and intestinal tumor cell lines. Hollingsworth, M.A., Strawhecker, J.M., Caffrey, T.C., Mack, D.R. Int. J. Cancer (1994)
- TNF-alpha activates MUC2 transcription via NF-kappaB but inhibits via JNK activation. Ahn, D.H., Crawley, S.C., Hokari, R., Kato, S., Yang, S.C., Li, J.D., Kim, Y.S. Cell. Physiol. Biochem. (2005)
- Altered phenotype of HT29 colonic adenocarcinoma cells following expression of the DCC gene. Velcich, A., Corner, G., Palumbo, L., Augenlicht, L. Oncogene (1999)
- UW-preservation of cultured human gallbladder epithelial cells: phenotypic alterations and differential mucin gene expression in the presence of bile. Campion, J.P., Porchet, N., Aubert, J.P., L'Helgoualc'h, A., Clément, B. Hepatology (1995)
- Coordinated localisation of mucins and trefoil peptides in the ulcer associated cell lineage and the gastrointestinal mucosa. Longman, R.J., Douthwaite, J., Sylvester, P.A., Poulsom, R., Corfield, A.P., Thomas, M.G., Wright, N.A. Gut (2000)
- Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells. Kim, Y.D., Kwon, E.J., Park, D.W., Song, S.Y., Yoon, S.K., Baek, S.H. Mol. Pharmacol. (2002)
- Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2. Chu, P.G., Schwarz, R.E., Lau, S.K., Yen, Y., Weiss, L.M. Am. J. Surg. Pathol. (2005)
- Bile acid-induced alterations of mucin production in differentiated human colon cancer cell lines. Shekels, L.L., Lyftogt, C.T., Ho, S.B. Int. J. Biochem. Cell Biol. (1996)
- Characterization of mucins in human lacrimal sac and nasolacrimal duct. Paulsen, F.P., Corfield, A.P., Hinz, M., Hoffmann, W., Schaudig, U., Thale, A.B., Berry, M. Invest. Ophthalmol. Vis. Sci. (2003)
- Mucin mRNA expression in lung adenocarcinoma cell lines and tissues. Yu, C.J., Yang, P.C., Shew, J.Y., Hong, T.M., Yang, S.C., Lee, Y.C., Lee, L.N., Luh, K.T., Wu, C.W. Oncology (1996)
- Primary mucinous (so-called colloid) carcinomas of the lung: a clinicopathologic and immunohistochemical study with special reference to CDX-2 homeobox gene and MUC2 expression. Rossi, G., Murer, B., Cavazza, A., Losi, L., Natali, P., Marchioni, A., Migaldi, M., Capitanio, G., Brambilla, E. Am. J. Surg. Pathol. (2004)
- Mucinous differentiation features associated with hormonal escape in a human prostate cancer xenograft. Legrier, M.E., de Pinieux, G., Boyé, K., Arvelo, F., Judde, J.G., Fontaine, J.J., Bara, J., Poupon, M.F. Br. J. Cancer (2004)