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Gene Review

Fgf6  -  fibroblast growth factor 6

Mus musculus

Synonyms: FGF-6, Fgf-6, Fibroblast growth factor 6, HBGF-6, HST-2, ...
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Disease relevance of Fgf6

  • In contrast, FGF-6(-/-) mutant mice show a severe regeneration defect with fibrosis and myotube degeneration [1].
  • Recent reports support the concept that FGF6 has a dual function in muscle regeneration, stimulating myoblast proliferation/migration and muscle differentiation/hypertrophy in a dose-dependent manner [2].
  • Identification of a fibroblast growth factor 6 (FGF6) gene in a non-mammalian vertebrate: continuous expression of FGF6 accompanies muscle fiber hyperplasia [3].

High impact information on Fgf6


Biological context of Fgf6


Anatomical context of Fgf6


Associations of Fgf6 with chemical compounds

  • We also report that in the presence of FGF6, the minor (0.5-2%) subpopulation of cells actively excluding Hoechst 33342 in a verapamil-dependent manner (SP phenotype) was increased to 15-20% and the expression of the mdr1a gene (but not mdr1b) was upregulated by 400-fold [8].
  • FGF6, added at 5 ng/ml and in the presence of heparin, increased the expression of a subset of muscle cell differentiation markers [10].

Regulatory relationships of Fgf6

  • IGF-II is up-regulated and myofibres are hypertrophied in regenerating soleus of mice lacking FGF6 [11].

Other interactions of Fgf6

  • We have studied the structure of the murine Fgf6 gene encoding a fibroblast growth factor with the purpose of looking for putative regulatory sequences in the 5' and 3' non-coding regions [12].
  • We present evidence that FGF6 is likely the key ligand for FGFR4 during muscle regeneration, and further suggest that FGF6 is released from necrotic myofibers where it is then sequestered by basal laminae [13].
  • The murine Fgf-6 gene is located in a region distinct from the Int-41 locus and belongs to a linkage group conserved between chromosome 12 in man and chromosome 6 in mouse [9].
  • First, there is an up-regulation of cyclin D1 mRNA, accounting for the regulating role of a high FGF6 concentration on proliferation, and second, differentiation markers such as CdkIs and MHC I and Tn I increase and cellular differentiation is accelerated [14].
  • We showed that an elevated transcript level for calcineurin Aalpha subunit correlated with a positive regulation of calcineurin A activity in regenerating soleus of the FGF6 (-/-) mice [15].

Analytical, diagnostic and therapeutic context of Fgf6

  • Denervation of fast-type muscles rapidly increased the LIF, but decreased the FGF6 expression [16].


  1. A role for FGF-6 in skeletal muscle regeneration. Floss, T., Arnold, H.H., Braun, T. Genes Dev. (1997) [Pubmed]
  2. FGF6 in myogenesis. Armand, A.S., Laziz, I., Chanoine, C. Biochim. Biophys. Acta (2006) [Pubmed]
  3. Identification of a fibroblast growth factor 6 (FGF6) gene in a non-mammalian vertebrate: continuous expression of FGF6 accompanies muscle fiber hyperplasia. Rescan, P.Y. Biochim. Biophys. Acta (1998) [Pubmed]
  4. Differentially expressed fibroblast growth factors regulate skeletal muscle development through autocrine and paracrine mechanisms. Hannon, K., Kudla, A.J., McAvoy, M.J., Clase, K.L., Olwin, B.B. J. Cell Biol. (1996) [Pubmed]
  5. Reduced mobility of fibroblast growth factor (FGF)-deficient myoblasts might contribute to dystrophic changes in the musculature of FGF2/FGF6/mdx triple-mutant mice. Neuhaus, P., Oustanina, S., Loch, T., Krüger, M., Bober, E., Dono, R., Zeller, R., Braun, T. Mol. Cell. Biol. (2003) [Pubmed]
  6. Expression of the Fgf6 gene is restricted to developing skeletal muscle in the mouse embryo. deLapeyrière, O., Ollendorff, V., Planche, J., Ott, M.O., Pizette, S., Coulier, F., Birnbaum, D. Development (1993) [Pubmed]
  7. Apparent normal phenotype of Fgf6-/- mice. Fiore, F., Planche, J., Gibier, P., Sebille, A., deLapeyrière, O., Birnbaum, D. Int. J. Dev. Biol. (1997) [Pubmed]
  8. FGF6 mediated expansion of a resident subset of cells with SP phenotype in the C2C12 myogenic line. Israeli, D., Benchaouir, R., Ziaei, S., Rameau, P., Gruszczynski, C., Peltekian, E., Danos, O., Garcia, L. J. Cell. Physiol. (2004) [Pubmed]
  9. Structure, chromosome mapping and expression of the murine Fgf-6 gene. de Lapeyriere, O., Rosnet, O., Benharroch, D., Raybaud, F., Marchetto, S., Planche, J., Galland, F., Mattei, M.G., Copeland, N.G., Jenkins, N.A. Oncogene (1990) [Pubmed]
  10. FGF6 modulates the expression of fibroblast growth factor receptors and myogenic genes in muscle cells. Pizette, S., Coulier, F., Birnbaum, D., DeLapeyrière, O. Exp. Cell Res. (1996) [Pubmed]
  11. IGF-II is up-regulated and myofibres are hypertrophied in regenerating soleus of mice lacking FGF6. Armand, A.S., Lécolle, S., Launay, T., Pariset, C., Fiore, F., Della Gaspera, B., Birnbaum, D., Chanoine, C., Charbonnier, F. Exp. Cell Res. (2004) [Pubmed]
  12. Isolation and sequence of the murine Fgf6 cDNA. Ollendorff, V., Rosnet, O., Marics, I., Birnbaum, D., deLapeyrière, O. Biochimie (1992) [Pubmed]
  13. Embryonic myogenesis pathways in muscle regeneration. Zhao, P., Hoffman, E.P. Dev. Dyn. (2004) [Pubmed]
  14. Injection of FGF6 accelerates regeneration of the soleus muscle in adult mice. Armand, A.S., Launay, T., Pariset, C., Della Gaspera, B., Charbonnier, F., Chanoine, C. Biochim. Biophys. Acta (2003) [Pubmed]
  15. FGF6 regulates muscle differentiation through a calcineurin-dependent pathway in regenerating soleus of adult mice. Armand, A.S., Pariset, C., Laziz, I., Launay, T., Fiore, F., Della Gaspera, B., Birnbaum, D., Charbonnier, F., Chanoine, C. J. Cell. Physiol. (2005) [Pubmed]
  16. Differential adaptation of growth and differentiation factor 8/myostatin, fibroblast growth factor 6 and leukemia inhibitory factor in overloaded, regenerating and denervated rat muscles. Sakuma, K., Watanabe, K., Sano, M., Uramoto, I., Totsuka, T. Biochim. Biophys. Acta (2000) [Pubmed]
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