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Gene Review

ADRA1B  -  adrenoceptor alpha 1B

Homo sapiens

Synonyms: ADRA1, ALPHA1BAR, Alpha-1B adrenergic receptor, Alpha-1B adrenoceptor, Alpha-1B adrenoreceptor
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Disease relevance of ADRA1B


High impact information on ADRA1B


Biological context of ADRA1B

  • For both ADRA1A and ADRA1B, haplotype superstructures may represent a novel, higher-level hierarchy in the human genome, which may reduce redundancy of testing by further aggregation of genotype data [8].
  • To investigate the generality of 3i domain-induced inhibition of receptor activity further, the 3i domains of two Gq-coupled receptors (alpha 1BAR and M1AChR) and two Gi-coupled receptors (alpha 2AAR and M2AChR) were tested for effects on the second messenger generation mediated by each of the four receptors [9].
  • Localization on different human chromosomes provides evidence that the bovine cDNA is distinct from the hamster alpha 1B-adrenergic receptor [10].
  • Even though alpha 1C- and alpha 1BARs activate polyphosphoinositide hydrolysis by similar biochemical mechanisms, the alpha 1CAR couples to phospholipase C more efficiently than does the alpha 1BAR; activation of the alpha 1CAR results in a 2-3-fold greater increase in inositol phosphates, compared with the alpha 1BAR [11].
  • Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation [12].

Anatomical context of ADRA1B


Associations of ADRA1B with chemical compounds


Other interactions of ADRA1B

  • First, ADRA1B is on 5q but is several million bases, rather than a few hundred thousand bases, from ADRB2 [19].
  • In stellate cells, besides a strong label of alpha 2a adrenergic receptor mRNA in all and moderate label of alpha 2b message in select stellate cells, the inner stellate cells are also moderately positive for alpha 1b adrenergic receptor mRNA [20].
  • Compared to the alpha 1bAR, the alpha 1aAR has several more cis regulatory elements, suggesting more complex regulation [21].
  • Although the alpha 1B2i domain had no effect on receptor/G protein coupling for any receptor tested, the alpha 1B3i domain inhibited signaling mediated by alpha 1BAR and M1AChR but not by D1ADR, while the alpha 1B4i domain inhibited signaling mediated by each of the receptors [9].
  • The RNase protection assay confirmed the absence of the alpha 1b adrenoceptor, the ratio of alpha 1a and alpha 1d being 4:1 [22].

Analytical, diagnostic and therapeutic context of ADRA1B


  1. Frequent reduced expression of alpha-1B-adrenergic receptor caused by aberrant promoter methylation in gastric cancers. Noda, H., Miyaji, Y., Nakanishi, A., Konishi, F., Miki, Y. Br. J. Cancer (2007) [Pubmed]
  2. Patterns of alpha-1-adrenergic receptor expression in regenerating and neoplastic hepatic tissue. Kost, D.P., DeFrances, M.C., Lee, C.R., Michalopoulos, G.K. Pathobiology (1992) [Pubmed]
  3. A. Al Khayer, I. Sedki and K. Adra on "Painless reduction of anterior shoulder dislocation by Kocher's method". Chitgopkar, S.D., Khan, n.u.l.l. Injury. (2006) [Pubmed]
  4. Glucocorticoids induce transcription and expression of the alpha 1B adrenergic receptor gene in DTT1 MF-2 smooth muscle cells. Sakaue, M., Hoffman, B.B. J. Clin. Invest. (1991) [Pubmed]
  5. Functional effects of protein kinase C activation on the human cardiac Na+ channel. Murray, K.T., Hu, N.N., Daw, J.R., Shin, H.G., Watson, M.T., Mashburn, A.B., George, A.L. Circ. Res. (1997) [Pubmed]
  6. The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis. Diviani, D., Lattion, A.L., Abuin, L., Staub, O., Cotecchia, S. J. Biol. Chem. (2003) [Pubmed]
  7. Phospholipase Cdelta1 is a guanine nucleotide exchanging factor for transglutaminase II (Galpha h) and promotes alpha 1B-adrenoreceptor-mediated GTP binding and intracellular calcium release. Baek, K.J., Kang, S., Damron, D., Im, M. J. Biol. Chem. (2001) [Pubmed]
  8. Haplotype block and superblock structures of the alpha1-adrenergic receptor genes reveal echoes from the chromosomal past. Buzas, B., Belfer, I., Hipp, H., Lorincz, I., Evans, C., Phillips, G., Taubman, J., Max, M.B., Goldman, D. Mol. Genet. Genomics (2004) [Pubmed]
  9. Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor. Hawes, B.E., Luttrell, L.M., Exum, S.T., Lefkowitz, R.J. J. Biol. Chem. (1994) [Pubmed]
  10. Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype. Schwinn, D.A., Lomasney, J.W., Lorenz, W., Szklut, P.J., Fremeau, R.T., Yang-Feng, T.L., Caron, M.G., Lefkowitz, R.J., Cotecchia, S. J. Biol. Chem. (1990) [Pubmed]
  11. The alpha 1C-adrenergic receptor: characterization of signal transduction pathways and mammalian tissue heterogeneity. Schwinn, D.A., Page, S.O., Middleton, J.P., Lorenz, W., Liggett, S.B., Yamamoto, K., Lapetina, E.G., Caron, M.G., Lefkowitz, R.J., Cotecchia, S. Mol. Pharmacol. (1991) [Pubmed]
  12. Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation. Kjelsberg, M.A., Cotecchia, S., Ostrowski, J., Caron, M.G., Lefkowitz, R.J. J. Biol. Chem. (1992) [Pubmed]
  13. Expression of alpha 1-adrenergic receptor subtype mRNA in rat tissues and human SK-N-MC neuronal cells: implications for alpha 1-adrenergic receptor subtype classification. Price, D.T., Chari, R.S., Berkowitz, D.E., Meyers, W.C., Schwinn, D.A. Mol. Pharmacol. (1994) [Pubmed]
  14. Coupling of the expressed alpha 1B-adrenergic receptor to the phospholipase C pathway in Xenopus oocytes. The role of Go. Blitzer, R.D., Omri, G., De Vivo, M., Carty, D.J., Premont, R.T., Codina, J., Birnbaumer, L., Cotecchia, S., Caron, M.G., Lefkowitz, R.J. J. Biol. Chem. (1993) [Pubmed]
  15. The pharmacological profile of cloned and stably expressed alpha 1b-adrenoceptor in CHO cells. Horie, K., Hirasawa, A., Tsujimoto, G. Eur. J. Pharmacol. (1994) [Pubmed]
  16. Cycloheximide induces the alpha 1B adrenergic receptor gene by activation of transcription in DDT1 MF-2 smooth muscle cells. Hu, Z.W., Hoffman, B.B. Mol. Pharmacol. (1993) [Pubmed]
  17. The effects of tamsulosin, a high affinity antagonist at functional alpha 1A- and alpha 1D-adrenoceptor subtypes. Noble, A.J., Chess-Williams, R., Couldwell, C., Furukawa, K., Uchyiuma, T., Korstanje, C., Chapple, C.R. Br. J. Pharmacol. (1997) [Pubmed]
  18. Noradrenaline contractions of human prostate mediated by alpha 1A-(alpha 1c-) adrenoceptor subtype. Marshall, I., Burt, R.P., Chapple, C.R. Br. J. Pharmacol. (1995) [Pubmed]
  19. Genes encoding adrenergic receptors are not clustered on the long arm of human chromosome 5. Loftus, S.K., Shiang, R., Warrington, J.A., Bengtsson, U., McPherson, J.D., Wasmuth, J.J. Cytogenet. Cell Genet. (1994) [Pubmed]
  20. Neuron specific alpha-adrenergic receptor expression in human cerebellum: implications for emerging cerebellar roles in neurologic disease. Schambra, U.B., Mackensen, G.B., Stafford-Smith, M., Haines, D.E., Schwinn, D.A. Neuroscience (2005) [Pubmed]
  21. Multiple potential regulatory elements in the 5' flanking region of the human alpha 1a-adrenergic receptor. Lee, K., Richardson, C.D., Razik, M.A., Kwatra, M.M., Schwinn, D.A. DNA Seq. (1998) [Pubmed]
  22. Detection of alpha 1-adrenoceptor subtypes in human hypertrophied prostate by in situ hybridization. Moriyama, N., Kurimoto, S., Horie, S., Nasu, K., Tanaka, T., Yano, K., Hirano, H., Tsujimoto, G., Kawabe, K. Histochem. J. (1996) [Pubmed]
  23. The alpha 1a and alpha 1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action. Cotecchia, S., Rossier, O., Fanelli, F., Leonardi, A., De Benedetti, P.G. Pharmaceutica acta Helvetiae. (2000) [Pubmed]
  24. Southwestern blots for detection of a DNA binding protein recognizing the alpha 1B-adrenergic receptor gene promoter. Gao, B., Kunos, G. Methods Mol. Biol. (2000) [Pubmed]
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