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Gene Review:

TMEM190 - transmembrane protein 190

Homo sapiens

Synonyms: MDAC1, Transmembrane protein 190

Hirata, J. et al., Bentley, S.A. et al., Apostolidou, E. et al., Roberts, D.M. et al., Chyka, P.A. et al., et al.

Roberts, Buckley, Mohammed Ebid, Abdel-Rahman,

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Disease relevance of MDAC1

The MDAC regimen was associated with significant toxicity in a cohort of patients with very advanced AML [1].
A gemtuzumab ozogamicin, DNX, cytarabine (ara-C) and CSA (MDAC) regimen was piloted in patients with refractory acute myelogenous leukemia (AML) (relapsed 10, primary refractory 1) (median age 37 years (16-67)) [1].

High impact information on MDAC1

The results indicate that the vast majority of these cultured MDAC were fibroblasts [2].
It has previously been shown that monolayer cultures derived adherent cells (MDAC), apparently consisting of fibroblasts, macrophages, epithelioid cells, and fat cells, can support long-term stem cell proliferation in vitro [2].
MDAC morphology was as described in previous studies, although fat cells were few in number [2].
Phagocytic activity against polystyrene microspheres was observed in 40% of MDAC [3].
The results showed that the decrease in plasma phenobarbital levels with MDAC was significantly greater than with either urinary alkalinization or the combined use of both [4].

Biological context of MDAC1

We describe our experience modeling phenytoin pharmacokinetics during therapy with MDAC in the treatment of two cases of acute phenytoin poisoning in children [5].

Anatomical context of MDAC1

In an attempt to clarify the significance of hydrocortisone (HC) in human long-term bone marrow cultures, the production of colony-stimulating activity (CSA) and colony-enhancing activity (CEA) by human bone marrow-derived adherent cells (MDAC) and the modulation by HC were examined [6].

Associations of MDAC1 with chemical compounds

RESULTS: Each drug exhibited enhanced elimination (P < .01) in the MDAC group except valproic acid [7].
There are also reports of multiple-dose activated charcoal (MDAC) increasing the clearance of phenytoin in adults [5].
OBJECTIVES: To determine the efficacy of antidotes for the treatment of acute cardenolide poisoning, in particular atropine, isoprenaline (isoproterenol), multiple-dose activated charcoal (MDAC), fructose-1,6-diphosphate, sodium bicarbonate, magnesium, phenytoin and anti-digoxin Fab antitoxin [8].

Analytical, diagnostic and therapeutic context of MDAC1

STUDY OBJECTIVE: To evaluate an animal model of multiple-dose activated charcoal (MDAC) therapy and correlate the pharmacokinetic properties of four drugs with the efficacy of MDAC [7].
After treatment of MDAC with 10(-6) mol/l HC, the CSA production was markedly enhanced, and after treatment of macrophages with 10(-6) mol/l HC, the CSA production was inhibited [6].

References

Pilot study of gemtuzumab ozogamicin, liposomal daunorubicin, cytarabine and cyclosporine regimen in patients with refractory acute myelogenous leukemia. Apostolidou, E., Cortes, J., Tsimberidou, A., Estey, E., Kantarjian, H., Giles, F.J. Leuk. Res. (2003) [Pubmed]
Some properties of marrow derived adherent cells in tissue culture. Bentley, S.A., Foidart, J.M. Blood (1980) [Pubmed]
Phagocytic properties of bone marrow fibroblasts. Bentley, S.A., Tralka, T.S., Alabaster, O. Exp. Hematol. (1981) [Pubmed]
Pharmacokinetics of phenobarbital during certain enhanced elimination modalities to evaluate their clinical efficacy in management of drug overdose. Mohammed Ebid, A.H., Abdel-Rahman, H.M. Therapeutic drug monitoring. (2001) [Pubmed]
Pharmacokinetic simulation of the effect of multiple-dose activated charcoal in phenytoin poisoning--report of two pediatric cases. Dolgin, J.G., Nix, D.E., Sanchez, J., Watson, W.A. DICP : the annals of pharmacotherapy. (1991) [Pubmed]
Hydrocortisone modulates colony-stimulating activity produced by human bone marrow-derived adherent cells. Hirata, J., Kaneko, S., Nishimura, J., Motomura, S., Ibayashi, H. Eur. J. Haematol. (1988) [Pubmed]
Correlation of drug pharmacokinetics and effectiveness of multiple-dose activated charcoal therapy. Chyka, P.A., Holley, J.E., Mandrell, T.D., Sugathan, P. Annals of emergency medicine. (1995) [Pubmed]
Antidotes for acute cardenolide (cardiac glycoside) poisoning. Roberts, D.M., Buckley, N.A. Cochrane database of systematic reviews (Online) (2006) [Pubmed]

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