Disease relevance of bet

• The antiretroviral activity of APOBEC3 is inhibited by the foamy virus accessory Bet protein [1].
• PFV Bet bound to human, but not mouse, APOBEC3 proteins in coexpressing cells, and this binding correlated with the specific inhibition of their incorporation into PFV virions [2].
• Persistent infection with primate foamy virus type 1 increases human immunodeficiency virus type 1 cell binding via a Bet-independent mechanism [3].
• The inability of delta HFV proviruses encoding a mutated bet gene to induce chronic infection suggests a role for Bet in this process [4].
• Of note, both PFV Bet and a second Bet protein, derived from an African green monkey foamy virus, rescued the infectivity of Vif-deficient human immunodeficiency virus type 1 (HIV-1) virions produced in the presence of African green monkey APOBEC3G and blocked the incorporation of this host factor into HIV-1 virion particles [2].

High impact information on bet

• HFV Bet follows an unconventional route to exit the cell since its secretion is not affected by brefeldin A, a drug which disrupts the trafficking between the endoplasmic reticulum and the Golgi complex [5].
• While gp160 and Bet proteins were both secreted into the supernatant, only Bet was taken up by recipient cells [6].
• Here, we show that infection of cell lines stably transduced by delta HFV DNA with the highly lytic HFV leads to chronic infections characterized by an absence of lysis, a balanced ratio of HFV to delta HFV, and a persistent Bet expression accompanied by a shutoff of structural genes [4].
• At least four novel gene products, termed Bet, Bes, Beo, and Bel3, are predicted to exist [7].
• The results indicate that FFV Bet is required for efficient virus replication [8].

Biological context of bet

• Mutagenesis was used to alter the Bel 2 and Bet or to abrogate their expression [8].

Anatomical context of bet

• The Bet-reactive antibodies were detected using a commercial streptavidin kit and revealed Bet in the cytoplasm of cells from different lymphoid tissues like lymphnodes, tonsils, thymus and spleen [9].

Other interactions of bet

• The predominant HSRV protein detected in immunoblots by both Bel 1- and Bel 2-specific antisera had an apparent molecular weight of 56 kDa and corresponds to Bet [10].

Analytical, diagnostic and therapeutic context of bet

• SFV-specific immunoglobulin G (IgG) antibodies, but not IgA antibodies, against the Gag and Bet proteins were detected, by Western blotting, in all sample types from infected humans and chimpanzees [11].
• To demonstrate feline FV (FFV) in tissues of experimentally infected cats three polyclonal monospecific antisera from rabbits against three different viral proteins, the structural Gag and the non-structural Bel 1 and Bet proteins were tested for their applicability in immunohistochemistry with paraffin sections [9].

References