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Gene Review

CCDC80  -  coiled-coil domain containing 80

Homo sapiens

Synonyms: Coiled-coil domain-containing protein 80, DRO1, Down-regulated by oncogenes protein 1, HBE245, SSG1, ...
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Disease relevance of CCDC80

  • Our findings suggest that inhibition of DRO1 expression may be an important event in the development of colorectal and pancreatic cancers [1].
  • Because expression of this gene was also down-regulated in RK3E transformed by several other oncogenes, the gene was named DRO1 for "down-regulated by oncogenes 1." Compared with corresponding normal tissues, DRO1 expression was found to be very reduced in colon and pancreatic cancer cell lines as well as in most colorectal cancer specimens [1].
  • P-glycoprotein was assessed by immunohistochemistry on paraffin-embedded tissue samples collected at time of diagnosis from 94 osteosarcoma patients, treated with the Italian Sarcoma Group/Scandinavian Sarcoma Group 1 (ISG/SSG 1) protocol [2].
  • The urinary excretion of N-acetyl-beta-D-glucosaminidase (UNAG) and retinol binding protein (URBP) was studied in 65 children with steroid sensitive multirelapsing nephrotic syndrome (MRNS): 28 on cyclosporin A (CyA) therapy, 22 on prednisolone (P), 15 off-treatment and in 32 normal children to assess renal tubular damage or dysfunction [3].
  • All renal failure patients had high mean urine RBP (URBP): HRS, 8 mg/L; ATN, 11 mg/L; CRF, 8 mg/L respectively; p less than 0.001 vs the rest [4].

High impact information on CCDC80

  • Ectopic expression of DRO1 in neoplastically transformed RK3E or colorectal and pancreatic cancer cell lines lacking endogenous DRO1 expression resulted in substantial inhibition of growth properties [1].
  • DRO1 was found to suppress anchorage independent growth and to sensitize cells to anoikis and CD95-induced apoptosis [1].
  • All workers were measured for PbB, urinary retinol-binding protein (URBP), urinary alpha1-microglobulin (Ualpha1m), urinary beta2-microglobulin (Ubeta 2m), urinary N-acetyl-beta -d-glucosaminidase (NAG), urinary aminolevulinic acid (ALAU), serum alpha1-microglobulin (Salpha1m), serum beta2-microglobulin (Sbeta 2m), and urinary albumin (Ualb) [5].
  • A comparative analysis of the subgroup of 94 patients considered for P-glycoprotein evaluation and the whole series of ISG/SSG 1 patients showed that this marker retained its prognostic value also in the latter group [2].
  • Pretreatment with AM-404+anandamide or URB 597+anandamide weakly enhanced nicotine-lever responding [6].

Biological context of CCDC80

  • DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells [1].
  • Measurements of urinary beta(2)-microglobulin (UB2MG), N-acetyl-beta-glucosaminidase (UNAG), retinol binding protein (URBP) and albumin (UALB) were used as markers of renal dysfunction [7].
  • Conventional cytogenetics in leukocytes revealed constitutional del(13q14) in five unilateral Rb (URB) and one trilateral Rb (TRB) [8].
  • Also, higher incidence of constitutional RB1 deletion mosaicism in unilateral than in bilateral Rb indicates that the constitutional genetic mosaicism in URB should be given serious consideration during genetic counseling [8].
  • Bone marrow stromal cells (BMSCs) cultured in standard growth medium exhibited constitutive URB gene expression. When BMSCs were cultured in osteoblastic differentiation medium [9] , URB expression was drastically reduced after 7 days and not detectable after 14 days [10] .

Anatomical context of CCDC80


Associations of CCDC80 with chemical compounds

  • The urinary protein excretion was expressed in relation to that of creatinine (UNAG/UC in mumol pnp/h/mmol; URBP/UC in microgram/mmol) [3].


  1. DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells. Bommer, G.T., Jäger, C., Dürr, E.M., Baehs, S., Eichhorst, S.T., Brabletz, T., Hu, G., Fröhlich, T., Arnold, G., Kress, D.C., Göke, B., Fearon, E.R., Kolligs, F.T. J. Biol. Chem. (2005) [Pubmed]
  2. May P-glycoprotein status be used to stratify high-grade osteosarcoma patients? Results from the Italian/Scandinavian Sarcoma Group 1 treatment protocol. Serra, M., Pasello, M., Manara, M.C., Scotlandi, K., Ferrari, S., Bertoni, F., Mercuri, M., Alvegard, T.A., Picci, P., Bacci, G., Smeland, S. Int. J. Oncol. (2006) [Pubmed]
  3. Tubular proteinuria in steroid sensitive multi-relapsing nephrotic syndrome. Piqueras, A.I., Shah, V., Hulton, S.A., Barratt, T.M., Dillon, M.J. Clin. Nephrol. (1993) [Pubmed]
  4. Analysis of serum and urinary retinol binding protein in hepato-renal syndrome. Bosin, E., Monji, N. Clin. Biochem. (1987) [Pubmed]
  5. Possible influence of delta-aminolevulinic acid dehydratase polymorphism and susceptibility to renal toxicity of lead: a study of a Vietnamese population. Chia, S.E., Zhou, H., Tham, M.T., Yap, E., Dong, N.V., Tu, N.H., Chia, K.S. Environ. Health Perspect. (2005) [Pubmed]
  6. Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats. Zaniewska, M., McCreary, A.C., Przegaliński, E., Filip, M. Eur. J. Pharmacol. (2006) [Pubmed]
  7. Biomarkers of cadmium and arsenic interactions. Nordberg, G.F., Jin, T., Hong, F., Zhang, A., Buchet, J.P., Bernard, A. Toxicol. Appl. Pharmacol. (2005) [Pubmed]
  8. Constitutional genomic instability, chromosome aberrations in tumor cells and retinoblastoma. Amare Kadam, P.S., Ghule, P., Jose, J., Bamne, M., Kurkure, P., Banavali, S., Sarin, R., Advani, S. Cancer Genet. Cytogenet. (2004) [Pubmed]
  9. Gene expression profile of human bone marrow stromal cells determined by restriction fragment differential display analysis. Monticone, M., Liu, Y., Tonachini, L., Mastrogiacomo, M., Parodi, S., Quarto, R., Cancedda, R., Castagnola, P. J. Cell. Biochem. (2004) [Pubmed]
  10. URB expression in human bone marrow stromal cells and during mouse development. Liu, Y., Monticone, M., Tonachini, L., Mastrogiacomo, M., Marigo, V., Cancedda, R., Castagnola, P. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  11. URB expression in human bone marrow stromal cells and during mouse development. Liu, Y., Monticone, M., Tonachini, L., Mastrogiacomo, M., Marigo, V., Cancedda, R., Castagnola, P. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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