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Gene Review

Ccdc80  -  coiled-coil domain containing 80

Rattus norvegicus

Synonyms: CL2, Coiled-coil domain-containing protein 80, Down-regulated by oncogenes 1 protein, Dro1, SSG-1, ...
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Disease relevance of Ssg1


Psychiatry related information on Ssg1

  • Thus, the present study adds novel evidence further supporting that the BNST and the central nucleus of the amygdala form part of an adrenal steroid-sensitive extrahypothalamic circuit that has been involved in fear and anxiety responses and in clinical syndromes such as melancholic depression, posttraumatic stress disorders, and addiction [5].

High impact information on Ssg1


Chemical compound and disease context of Ssg1


Biological context of Ssg1


Anatomical context of Ssg1

  • We report the cloning of a novel gene [steroid-sensitive gene 1 (SSG1)] that is regulated by E(2) in the rat uterus and mammary gland [17].
  • The presence of VGLUT2 mRNA in steroid-sensitive regions of the hypothalamus, such as the anteroventral periventricular, paraventricular, or ventromedial nuclei indicates that gonadal and adrenal steroid can directly alter the functions of these glutamatergic neurons [18].
  • Since parvocellular but not magnocellular neurons of the paraventricular nucleus have been demonstrated to be steroid sensitive in immunohistochemical studies, we suggest CRF may act directly or indirectly upon magnocellular neurons to increase OT release [19].
  • Plasma ACTH, corticosteroid-binding globulin (CBG), and thymus weight were measured in the morning or evening, and these steroid-sensitive end points were related to the circulating concentrations of B (total B - CBG-bound B), total DEX, and total ALDO [20].
  • The rat lumbar spinal cord contains the steroid-sensitive spinal nucleus of the bulbocavernosus (SNB), whose motoneurons innervate perineal muscles involved in copulatory reflexes [21].

Associations of Ssg1 with chemical compounds


Co-localisations of Ssg1

  • GAL is extensively colocalized within these steroid-sensitive cell groups where its expression is upregulated by gonadal hormones [27].

Other interactions of Ssg1

  • In conjunction with previous evidence that the perinuclear zone GABA neurones are an important source of GABA terminals in the SON, these results provide a morphological basis for the hypothesis that perinuclear zone GABA neurones may be part of a steroid-sensitive neural circuitry transmitting oestrogen input to oxytocin neurones in the SON [28].
  • Furthermore the data demonstrates a steroid-sensitive stress mediated increase in proenkephalin A mRNA which provides additional evidence for a role of the endogenous opiates in the hypothalamic neuroendocrine response to stress [29].

Analytical, diagnostic and therapeutic context of Ssg1


  1. The mechanism of altered neural function in a rat model of acute colitis. Jacobson, K., McHugh, K., Collins, S.M. Gastroenterology (1997) [Pubmed]
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  3. Circulating vascular endothelial growth factor is not increased during relapses of steroid-sensitive nephrotic syndrome. Webb, N.J., Watson, C.J., Roberts, I.S., Bottomley, M.J., Jones, C.A., Lewis, M.A., Postlethwaite, R.J., Brenchley, P.E. Kidney Int. (1999) [Pubmed]
  4. Rat C6 glioma cell growth is related to glucose transport and metabolism. Nagamatsu, S., Nakamichi, Y., Inoue, N., Inoue, M., Nishino, H., Sawa, H. Biochem. J. (1996) [Pubmed]
  5. Adrenalectomy decreases corticotropin-releasing hormone gene expression and increases noradrenaline and dopamine extracellular levels in the rat lateral bed nucleus of the stria terminalis. Santibañez, M., Gysling, K., Forray, M.I. J. Neurosci. Res. (2005) [Pubmed]
  6. Estrogen differentially regulates neuropeptide gene expression in a sexually dimorphic olfactory pathway. Simerly, R.B., Young, B.J., Capozza, M.A., Swanson, L.W. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  7. Estrogen-induced alteration of mu-opioid receptor immunoreactivity in the medial preoptic nucleus and medial amygdala. Eckersell, C.B., Popper, P., Micevych, P.E. J. Neurosci. (1998) [Pubmed]
  8. Dexamethasone induces neuropeptide Y (NPY) expression and impairs insulin release in the insulin-producing cell line RINm5F. Release of NPY and insulin through different pathways. Myrsén-Axcrona, U., Karlsson, S., Sundler, F., Ahrén, B. J. Biol. Chem. (1997) [Pubmed]
  9. Cloning and molecular characterization of a novel gene strongly induced by the adenovirus E1A gene in rat thyroid cells. Visconti, R., Schepis, F., Iuliano, R., Pierantoni, G.M., Zhang, L., Carlomagno, F., Battaglia, C., Martelli, M.L., Trapasso, F., Santoro, M., Fusco, A. Oncogene (2003) [Pubmed]
  10. IkappaB kinase-2-independent and -dependent inflammation in airway disease models: relevance of IKK-2 inhibition to the clinic. Birrell, M.A., Wong, S., Hardaker, E.L., Catley, M.C., McCluskie, K., Collins, M., Haj-Yahia, S., Belvisi, M.G. Mol. Pharmacol. (2006) [Pubmed]
  11. Cortisol-binding protein in the cytosol of rat carrageenin granuloma. Koshihara, Y., Yamagishi, M., Murota, S., Tsurufuji, S. Jpn. J. Pharmacol. (1975) [Pubmed]
  12. Sex differences in hormonal responses of vasopressin pathways in the rat brain. De Vries, G.J., al-Shamma, H.A. J. Neurobiol. (1990) [Pubmed]
  13. Distribution of androgen receptor immunoreactivity in the brainstem of male rats. Hamson, D.K., Jones, B.A., Watson, N.V. Neuroscience (2004) [Pubmed]
  14. Estrogen alters excitability but not morphology of a sexually dimorphic neuromuscular system in adult rats. Fargo, K.N., Foster, A.M., Harty, M.W., Sengelaub, D.R. J. Neurobiol. (2003) [Pubmed]
  15. Oxytocin-induced excitation of neurones in the rat central and medial amygdaloid nuclei. Terenzi, M.G., Ingram, C.D. Neuroscience (2005) [Pubmed]
  16. Changes in airway resistance by simultaneous exposure to TNF-alpha and IL-1beta in perfused rat lungs. Martin, C., Wohlsen, A., Uhlig, S. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  17. Cloning and characterization of a novel gene that is regulated by estrogen and is associated with mammary gland carcinogenesis. Marcantonio, D., Chalifour, L.E., Alaoui-Jamali, M.A., Alpert, L., Huynh, H.T. Endocrinology (2001) [Pubmed]
  18. Distribution of vesicular glutamate transporter-2 messenger ribonucleic Acid and protein in the septum-hypothalamus of the rat. Lin, W., McKinney, K., Liu, L., Lakhlani, S., Jennes, L. Endocrinology (2003) [Pubmed]
  19. Central administration of corticotropin-releasing factor modulates oxytocin secretion in the rat. Bruhn, T.O., Sutton, S.W., Plotsky, P.M., Vale, W.W. Endocrinology (1986) [Pubmed]
  20. Pharmacological evidence that the inhibition of diurnal adrenocorticotropin secretion by corticosteroids is mediated via type I corticosterone-preferring receptors. Dallman, M.F., Levin, N., Cascio, C.S., Akana, S.F., Jacobson, L., Kuhn, R.W. Endocrinology (1989) [Pubmed]
  21. Aromatase inhibition reduces dendritic growth in a sexually dimorphic rat spinal nucleus. Burke, K.A., Kuwajima, M., Sengelaub, D.R. J. Neurobiol. (1999) [Pubmed]
  22. Gonadal steroid hormone modulation of nociception, morphine antinociception and reproductive indices in male and female rats. Stoffel, E.C., Ulibarri, C.M., Craft, R.M. Pain (2003) [Pubmed]
  23. Sex difference in coexpression by galanin neurons accounts for sexual dimorphism of vasopressin in the bed nucleus of the stria terminalis. Planas, B., Kolb, P.E., Raskind, M.A., Miller, M.A. Endocrinology (1995) [Pubmed]
  24. Ovariectomy attenuates dendritic growth in hormone-sensitive spinal motoneurons. Hebbeler, S.L., Verhovshek, T., Sengelaub, D.R. J. Neurobiol. (2001) [Pubmed]
  25. Steroid-sensitive gene-1 is an androgen-regulated gene expressed in prostatic smooth muscle cells in vivo. Marcantonio, D., Chalifour, L.E., Alaoui-Jamali And H T Huynh, M.A., Alaoui-Jamali, M.A., Alaoui-Jamali, M.A., Huynh, H.T., Huynh, H.T. J. Mol. Endocrinol. (2001) [Pubmed]
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  27. Regulation of galanin in memory pathways. Miller, M.A. Ann. N. Y. Acad. Sci. (1998) [Pubmed]
  28. Immunocytochemical evidence for oestrogen receptors within GABA neurones located in the perinuclear zone of the supraoptic nucleus and GABAA receptor beta 2/beta 3 subunits on supraoptic oxytocin neurones. Herbison, A.E. J. Neuroendocrinol. (1994) [Pubmed]
  29. Glucocorticoid inhibition of stress-induced changes in hypothalamic corticotrophin-releasing factor messenger RNA and proenkephalin A messenger RNA. Harbuz, M.S., Lightman, S.L. Neuropeptides (1989) [Pubmed]
  30. Effect of the progesterone antagonist mifepristone on the hypothalamo-hypophysial-ovarian axis in rats. van der Schoot, P., Uilenbroek, J.T., Slappendel, E.J. J. Endocrinol. (1990) [Pubmed]
  31. The effect of steroids on the circulating lymphocyte population--VI. Studies of the thoracic duct T- and B-lymphocyte populations after neonatal thymectomy and prednisolone treatment. An immunofluorescence study in the rat. Hedman, L.A., Röckert, L.L., Lundin, P.M. Int. J. Immunopharmacol. (1984) [Pubmed]
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