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Gene Review

Hoxb3  -  homeobox B3

Mus musculus

Synonyms: Homeobox protein Hox-2.7, Homeobox protein Hox-B3, Homeobox protein MH-23, Hox-2.7, Hoxb-3
 
 
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High impact information on Hoxb3

  • These studies demonstrate that Krml1 directly activates expression of Hoxb-3 in r5 in combination with an Ets-related activation site, and suggest that kreisler plays a primary role in regulating segmental identity through Hox genes [1].
  • We have identified two new members (Hox-2.6 and Hox-2.7), which form part of this cluster of seven linked genes, and it appears that the Hox-2 locus is related by duplication and divergence to at least one other mouse homeo box cluster, Hox-1 [2].
  • Genetic analyses demonstrated that Krox20 is required for activity of the Hoxb3 r5 enhancer, but not of the Hoxa3 r5/6 enhancer [3].
  • In the segmented vertebrate hindbrain, the Hoxa3 and Hoxb3 genes are expressed at high relative levels in the rhombomeres (r) 5 and 6, and 5, respectively [3].
  • Analysis of the murine Hox-2.7 gene: conserved alternative transcripts with differential distributions in the nervous system and the potential for shared regulatory regions [4].
 

Biological context of Hoxb3

  • The most anterior neural expression domain of Hoxb3 is controlled by an r5 enhancer (element IVa); element IIIa directs reporter expression in the anterior spinal cord and hindbrain up to r6, and the region A enhancer (in element I) mediates posterior neural expression [5].
  • To assay the regulatory potential of DNA fragments in this interval we have used transgenic analysis with a lacZ reporter gene to locate cis-elements for directing the dynamic patterns of Hoxb3 expression [5].
  • When tested in combinations, these cis-elements appear to work as modules in an additive manner to recapitulate the major endogenous expression patterns of Hoxb3 during embryogenesis [5].
  • Our detailed analysis has identified four new and widely spaced cis-acting regulatory regions that can together account for major aspects of the Hoxb3 expression pattern [5].
  • Here we find that mice deficient in both Hoxb3 and Hoxb4 have defects in endogenous hematopoiesis with reduced cellularity in hematopoietic organs and diminished number of hematopoietic progenitors without perturbing lineage commitment [6].
 

Anatomical context of Hoxb3

  • This demonstrates that Hoxa3, along with its paralog Hoxb3, is a direct target of kreisler in the mouse hindbrain [7].
  • The expression of the paralogous Hoxa3 and Hoxb3 genes extends from the posterior spinal cord up to the rhombomere (r) 4/5 boundary and both genes are upregulated specifically in r5 [7].
  • The mesoderm-specific element (Va) directs reporter expression to prevertebra C1 at 12.5 dpc, which is the anterior limit of paraxial mesoderm expression for Hoxb3 [5].
  • Hoxb3, Hoxd3 double mutants show no obvious defects in the thymus or parathyroids [8].
  • This unique function may be conferred by the expression of Hoxa3, but not Hoxb3 nor Hoxd3, in the pharyngeal pouch endoderm [8].
 

Regulatory relationships of Hoxb3

  • In this region, Hoxb-1 is ectopically expressed, Hoxb-3 is ectopically up-regulated and Hoxd-4 expression is abolished [9].
 

Other interactions of Hoxb3

  • Rostral expression boundaries of Hoxb-3 and Hoxb-4 are displaced from their normal positions at r4/5 and r6/7 to the approximate positions of r3/4 and r4/5, respectively [10].
  • Hoxb-3 and b-4 are expressed in the mesenchyme of the trachea, mainstem bronchi, and distal lung, whereas Hoxb-2 and b-5 mRNA are present only in the mesenchyme of the distal lung buds [11].
  • In this study, we examined the time course of Hoxb3 expression during late gastrulation and early segmentation of rae28-deficient mice [12].
  • Here, there were delays in the expression of Hoxb-3 following b-1, Hoxb-4 following b-3, and Hoxb-6 following b-4 [13].

References

  1. Segmental regulation of Hoxb-3 by kreisler. Manzanares, M., Cordes, S., Kwan, C.T., Sham, M.H., Barsh, G.S., Krumlauf, R. Nature (1997) [Pubmed]
  2. Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene. Graham, A., Papalopulu, N., Lorimer, J., McVey, J.H., Tuddenham, E.G., Krumlauf, R. Genes Dev. (1988) [Pubmed]
  3. Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain. Manzanares, M., Nardelli, J., Gilardi-Hebenstreit, P., Marshall, H., Giudicelli, F., Martínez-Pastor, M.T., Krumlauf, R., Charnay, P. EMBO J. (2002) [Pubmed]
  4. Analysis of the murine Hox-2.7 gene: conserved alternative transcripts with differential distributions in the nervous system and the potential for shared regulatory regions. Sham, M.H., Hunt, P., Nonchev, S., Papalopulu, N., Graham, A., Boncinelli, E., Krumlauf, R. EMBO J. (1992) [Pubmed]
  5. Regulatory analysis of the mouse Hoxb3 gene: multiple elements work in concert to direct temporal and spatial patterns of expression. Kwan, C.T., Tsang, S.L., Krumlauf, R., Sham, M.H. Dev. Biol. (2001) [Pubmed]
  6. Reduced proliferative capacity of hematopoietic stem cells deficient in Hoxb3 and Hoxb4. Björnsson, J.M., Larsson, N., Brun, A.C., Magnusson, M., Andersson, E., Lundström, P., Larsson, J., Repetowska, E., Ehinger, M., Humphries, R.K., Karlsson, S. Mol. Cell. Biol. (2003) [Pubmed]
  7. Conserved and distinct roles of kreisler in regulation of the paralogous Hoxa3 and Hoxb3 genes. Manzanares, M., Cordes, S., Ariza-McNaughton, L., Sadl, V., Maruthainar, K., Barsh, G., Krumlauf, R. Development (1999) [Pubmed]
  8. Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands. Manley, N.R., Capecchi, M.R. Dev. Biol. (1998) [Pubmed]
  9. Key roles of retinoic acid receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst in the mouse. Dupé, V., Ghyselinck, N.B., Wendling, O., Chambon, P., Mark, M. Development (1999) [Pubmed]
  10. Altered rhombomere-specific gene expression and hyoid bone differentiation in the mouse segmentation mutant, kreisler (kr). Frohman, M.A., Martin, G.R., Cordes, S.P., Halamek, L.P., Barsh, G.S. Development (1993) [Pubmed]
  11. Expression of Hoxb genes in the developing mouse foregut and lung. Bogue, C.W., Lou, L.J., Vasavada, H., Wilson, C.M., Jacobs, H.C. Am. J. Respir. Cell Mol. Biol. (1996) [Pubmed]
  12. Regulation of Hoxb3 expression in the hindbrain and pharyngeal arches by rae28, a member of the mammalian Polycomb group of genes. Tomotsune, D., Shirai, M., Takihara, Y., Shimada, K. Mech. Dev. (2000) [Pubmed]
  13. Temporal colinearity in expression of anterior Hox genes in developing chick embryos. Gaunt, S.J., Strachan, L. Dev. Dyn. (1996) [Pubmed]
 
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