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Gene Review

Hoxb2  -  homeobox B2

Mus musculus

Synonyms: AI894218, Homeobox protein Hox-2.8, Homeobox protein Hox-B2, Hox-2.8, Hoxbes2
 
 
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High impact information on Hoxb2

 

Biological context of Hoxb2

 

Anatomical context of Hoxb2

  • On the basis of these experiments we conclude that the r4-restricted domain of Hoxb2 in the hindbrain is the result of a direct cross-regulatory interaction by Hoxb1 involving vertebrate Pbx proteins as cofactors [2].
  • We show that, already before primitive streak formation, prior to initial expression of the first Hox gene, a dramatic transcriptional stimulation of the 3'most genes, Hoxb1 and Hoxb2, is observed upon a short pulse of exogenous retinoic acid (RA), whereas it is not in the case for more 5', cluster-internal, RA-responsive Hoxb genes [8].
  • Hoxb-3 and b-4 are expressed in the mesenchyme of the trachea, mainstem bronchi, and distal lung, whereas Hoxb-2 and b-5 mRNA are present only in the mesenchyme of the distal lung buds [9].
 

Associations of Hoxb2 with chemical compounds

 

Physical interactions of Hoxb2

 

Regulatory relationships of Hoxb2

  • Krox-20 has been shown to directly regulate the Hoxb-2 gene and we wanted to determine if it was involved in regulating multiple Hox genes as a part of its functional role [11].
 

Other interactions of Hoxb2

  • This suggests that part of the functional role of Hoxb1 in maintaining r4 identity may be mediated by the Hoxb2 gene [2].
  • Moreover, Hoxa2 and Hoxb2 can functionally synergize in controlling the development of ventral neuronal subtypes in rhombomere 3 (r3) [3].
  • Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes [5].
  • Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins [4].
  • The expression pattern of Hox-2.8 during embryogenesis extends the trend established by genes from Hox-2.5 to -2.7 of successively anterior domains of expression in the neural tube [7].

References

  1. The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation. Sham, M.H., Vesque, C., Nonchev, S., Marshall, H., Frain, M., Gupta, R.D., Whiting, J., Wilkinson, D., Charnay, P., Krumlauf, R. Cell (1993) [Pubmed]
  2. Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1. Maconochie, M.K., Nonchev, S., Studer, M., Chan, S.K., Pöpperl, H., Sham, M.H., Mann, R.S., Krumlauf, R. Genes Dev. (1997) [Pubmed]
  3. Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain. Davenne, M., Maconochie, M.K., Neun, R., Pattyn, A., Chambon, P., Krumlauf, R., Rijli, F.M. Neuron (1999) [Pubmed]
  4. Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins. Ferretti, E., Marshall, H., Pöpperl, H., Maconochie, M., Krumlauf, R., Blasi, F. Development (2000) [Pubmed]
  5. Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes. Gavalas, A., Ruhrberg, C., Livet, J., Henderson, C.E., Krumlauf, R. Development (2003) [Pubmed]
  6. Hoxb-2 transcriptional activation in rhombomeres 3 and 5 requires an evolutionarily conserved cis-acting element in addition to the Krox-20 binding site. Vesque, C., Maconochie, M., Nonchev, S., Ariza-McNaughton, L., Kuroiwa, A., Charnay, P., Krumlauf, R. EMBO J. (1996) [Pubmed]
  7. A yeast artificial chromosome containing the mouse homeobox cluster Hox-2. Rubock, M.J., Larin, Z., Cook, M., Papalopulu, N., Krumlauf, R., Lehrach, H. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  8. Hox cluster polarity in early transcriptional availability: a high order regulatory level of clustered Hox genes in the mouse. Roelen, B.A., de Graaff, W., Forlani, S., Deschamps, J. Mech. Dev. (2002) [Pubmed]
  9. Expression of Hoxb genes in the developing mouse foregut and lung. Bogue, C.W., Lou, L.J., Vasavada, H., Wilson, C.M., Jacobs, H.C. Am. J. Respir. Cell Mol. Biol. (1996) [Pubmed]
  10. Postimplantation mouse embryos cultured in vitro. Assessment with whole-mount immunostaining and in situ hybridization. Van Maele-Fabry, G., Clotman, F., Gofflot, F., Bosschaert, J., Picard, J.J. Int. J. Dev. Biol. (1997) [Pubmed]
  11. Segmental expression of Hoxa-2 in the hindbrain is directly regulated by Krox-20. Nonchev, S., Vesque, C., Maconochie, M., Seitanidou, T., Ariza-McNaughton, L., Frain, M., Marshall, H., Sham, M.H., Krumlauf, R., Charnay, P. Development (1996) [Pubmed]
 
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